scholarly journals Enzyme-activatable fluorescent probes for β-galactosidase: from design to biological applications

2021 ◽  
Author(s):  
Yongkang Yao ◽  
Yutao Zhang ◽  
Chenxu Yan ◽  
Wei-Hong Zhu ◽  
Zhiqian Guo
Keyword(s):  
Fluorescent Probes ◽  
Molecular Design ◽  
Design Strategy ◽  
Biological Applications ◽  
Dual Mode ◽  
Luminescence Imaging ◽  
Turn On

This review highlights the molecular design strategy of β-galactosidase-activatable probes from turn-on mode to ratiometric mode, from ACQ to AIE-active probes, from NIR-I to NIR-II imaging and dual-mode of chemo-fluoro-luminescence imaging.

Advances in fluorescent sensors for β-galactosidase

2021 ◽  
Author(s):  
Meng Li ◽  
Mengqing Yang ◽  
Wei-Hong Zhu
Keyword(s):  
Fluorescent Probes ◽  
Molecular Design ◽  
Design Strategy ◽  
Fluorescent Sensors ◽  
Detection Accuracy ◽  
Biological Applications ◽  
Accuracy Enhancement ◽  
Aggregation Induced Emission

This minireview summarizes advances in the molecular design strategy and biological applications of fluorescent probes for β-galactosidase (β-Gal), focusing on detection accuracy enhancement and aggregation-induced emission for background minimization.

scholarly journals Asymmetric and Reduced Xanthene Fluorophores: Synthesis, Photochemical Properties, and Application to Activatable Fluorescent Probes for Detection of Nitroreductase

Molecules ◽  
2019 ◽  
Vol 24 (17) ◽  
pp. 3206 ◽  
Author(s):  
More ◽  
Lim ◽  
Kang ◽  
Yun ◽  
Yee ◽  
...  
Keyword(s):  
Fluorescent Probes ◽  
Cross Coupling ◽  
Synthetic Methods ◽  
Enzymatic Reactions ◽  
Biological Applications ◽  
Background Signal ◽  
Xanthene Dyes ◽  
High Background ◽  
Turn On ◽  
Photochemical Properties

Xanthene fluorophores, including fluorescein, rhodol, and rhodamines, are representative classes of fluorescent probes that have been applied in the detection and visualization of biomolecules. “Turn on” activatable fluorescent probes, that can be turned on in response to enzymatic reactions, have been developed and prepared to reduce the high background signal of “always-on” fluorescent probes. However, the development of activity-based fluorescent probes for biological applications, using simple xanthene dyes, is hampered by their inefficient synthetic methods and the difficulty of chemical modifications. We have, thus, developed a highly efficient, versatile synthetic route to developing chemically more stable reduced xanthene fluorophores, based on fluorescein, rhodol, and rhodamine via continuous Pd-catalyzed cross-coupling. Their fluorescent nature was evaluated by monitoring fluorescence with variation in the concentration, pH, and solvent. As an application to activatable fluorescent probe, nitroreductase (NTR)-responsive fluorescent probes were also developed using the reduced xanthene fluorophores, and their fluorogenic properties were evaluated.

Curcumin-based polarity fluorescent probes: Design strategy and biological applications

2020 ◽  
Vol 177 ◽  
pp. 108320 ◽  
Author(s):  
Linghao Hu ◽  
Donglei Shi ◽  
Xinming Li ◽  
Jin Zhu ◽  
Fei Mao ◽  
...  
Keyword(s):  
Fluorescent Probes ◽  
Design Strategy ◽  
Biological Applications

Establishment of Molecular Design Strategy To Obtain Activatable Fluorescent Probes for Carboxypeptidases

2018 ◽  
Vol 140 (5) ◽  
pp. 1767-1773 ◽  
Author(s):  
Yugo Kuriki ◽  
Mako Kamiya ◽  
Hidemasa Kubo ◽  
Toru Komatsu ◽  
Tasuku Ueno ◽  
...  
Keyword(s):  
Fluorescent Probes ◽  
Molecular Design ◽  
Design Strategy

scholarly journals Engineering the Interface between Inorganic Nanoparticles and Biological Systems through Ligand Design

Nanomaterials ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 1001
Author(s):  
Rui Huang ◽  
David C. Luther ◽  
Xianzhi Zhang ◽  
Aarohi Gupta ◽  
Samantha A. Tufts ◽  
...  
Keyword(s):  
Organic Synthesis ◽  
Molecular Design ◽  
Biological Systems ◽  
Ligand Design ◽  
Inorganic Nanoparticles ◽  
Organic Ligands ◽  
Biological Applications ◽  
Wide Range ◽  
Insight Into

Nanoparticles (NPs) provide multipurpose platforms for a wide range of biological applications. These applications are enabled through molecular design of surface coverages, modulating NP interactions with biosystems. In this review, we highlight approaches to functionalize nanoparticles with ”small” organic ligands (Mw < 1000), providing insight into how organic synthesis can be used to engineer NPs for nanobiology and nanomedicine.

scholarly journals Diketopyrrolopyrrole Fluorescent Probes, Photophysical and Biological Applications

Chemosensors ◽  
2021 ◽  
Vol 9 (3) ◽  
pp. 44
Author(s):  
Muhammad Aminu Auwalu ◽  
Shanshan Cheng
Keyword(s):  
Quantum Yield ◽  
Fluorescent Probes ◽  
Organic Dyes ◽  
Tumor Therapy ◽  
Research Area ◽  
Research Field ◽  
Review Article ◽  
Biological Applications ◽  
Chemistry Research ◽  
Cancer Tumor

Biological applications of fluorescent probes are rapidly increasing in the supramolecular chemistry research field. Several organic dyes are being utilized currently in developing and advancing this attractive research area, of which diketopyrrolopyrrole (DPP) organic dyes show an exceptional photophysical features (high-fluorescence quantum yield (FQY), good photochemical and thermal stability) that are essential properties for biological applications. Great efforts have been made in recent years towards developing novel fluorescent DPPs by different chemists for such applications, and some positive results have been reported. As a result, this review article gives an account of the progress that has so far been made very recently, mainly within the last decade, in that we selectively focus on and discuss more from 2015 to present on some recent scholarly achievements of fluorescent DPPs: quantum yield, aggregation-induced emission (AIE), solid-state emission, bio-imaging, cancer/tumor therapy, mitochondria staining and some polymeric fluorescent DPPs. Finally, this review article highlights researchers working on luminescent DPPs and the future prospects in some key areas towards designing DPP-based fluorescent probes in order to boost their photophysical and biological applications more effectively.

scholarly journals Molecular design strategy to alleviate environmental interference on two-photon fluorescence probes

2021 ◽  
Vol 2 (6) ◽  
pp. 100471
Author(s):  
Xingxing Zhang ◽  
Tianbing Ren ◽  
Qianling Zhang ◽  
Ting Zeng ◽  
Zhe Li ◽  
...  
Keyword(s):  
Molecular Design ◽  
Design Strategy ◽  
Fluorescence Probes ◽  
Two Photon ◽  
Two Photon Fluorescence ◽  
Photon Fluorescence ◽  
Environmental Interference

Rational design and crystal structure prediction of ring-fused double-PDI compounds as n-channel organic semiconductors: a DFT study

2021 ◽  
Author(s):  
Suryakanti Debata ◽  
Smruti R. Sahoo ◽  
Rudranarayan Khatua ◽  
Sridhar Sahu
Keyword(s):  
Crystal Structure ◽  
Charge Transport ◽  
Organic Semiconductors ◽  
Structure Prediction ◽  
Rational Design ◽  
Molecular Design ◽  
Design Strategy ◽  
Dft Study ◽  
Crystal Structure Prediction ◽  
Model Compounds

In this study, we present an effective molecular design strategy to develop the n-type charge transport characteristics in organic semiconductors, using ring-fused double perylene diimides (DPDIs) as the model compounds.

scholarly journals Molecular Design of Thermally Activated Delayed Fluorescent Emitters for Narrowband Orange−Red OLEDs: Boosted by a Cyano-Functionalization Strategy

2021 ◽  
Author(s):  
Yang Liu ◽  
Xin Xiao ◽  
Ran You ◽  
Zhengyang Bin ◽  
Jingsong You
Keyword(s):  
Molecular Design ◽  
Design Strategy ◽  
Color Purity ◽  
Thermally Activated ◽  
Red Oleds

The establishment of simple molecular design strategy to realize red-shifted emission while maintaining good color purity for multi-resonance induced thermally activated delayed fluorescent (MR-TADF) materials remains an appealing yet challenging...

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