scholarly journals Tale of Breslow Intermediate, a Central Player in N-Heterocyclic Carbene Organocatalysis: Then and Now

2021 ◽  
Author(s):  
Raghavan B. Sunoj ◽  
Monika Pareek ◽  
Yernaidu Reddi
Keyword(s):  
Natural Products ◽  
Heterocyclic Carbenes ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Active Compounds ◽  
Wide Range

N-heterocyclic carbenes (NHCs) belong to the popular family of organocatalysts used in a wide range of reactions, including that for the synthesis of complex natural products and biologically active compounds....

Copper-catalyzed N-arylation of pyrroles: An overview

2021 ◽  
Author(s):  
Kalathingal Nasreen Hisana ◽  
C. M. A. Afsina ◽  
Gopinathan Anilkumar
Keyword(s):  
Natural Products ◽  
Organic Synthesis ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Active Compounds ◽  
Wide Range

N-Arylated pyrroles have a wide range of applications in pharmaceuticals, agrochemical industry and organic synthesis. They are intermediates for the formation of many biologically active compounds and natural products. Over...

Chemical modification and Physicochemical properties of new derivatives 5-(thiophen-3-ilmethyl)-4-R1-1,2,4-triazole-3-thiol

2021 ◽  
pp. 4621-4629
Author(s):  
O.A. Bihdan ◽  
V.V. Parchenko
Keyword(s):  
Physicochemical Properties ◽  
High Reactivity ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Active Compounds ◽  
Triazole Derivatives ◽  
Pharmaceutical Ingredients ◽  
Current Trends ◽  
Wide Range ◽  
Derivatives Of

Current trends in the search for new biologically active compounds among synthetic molecules have arguably proved a priority in studies of the heterocyclic 1,2,4-triazole system. For many years, 1,2,4-triazole derivatives remain the object of close attention of scientists of various scientific fields. The unique properties of 1,2,4-triazole derivatives include high reactivity, which allows different modification of this system, practical absence of toxicity of these derivatives and the presence of a wide range of biological, pharmacological properties, which in the complex provides the prerequisites for the creation of new biologically active compounds, and in the future, active pharmaceutical ingredients (AFI). The aim of our work is to investigate some transformations in a number of derivatives of 5-(thiophen-3-ylmethyl) -4-R1-1,2,4-triazole-3-thiol, to study the physicochemical properties of the new synthesized compounds. A well-known fact remains the successful attempt of many scientists involved in the study of the heterocyclic 1,2,4-triazole system to synthesize potential biologically active compounds. The process of creating new molecules is very painstaking and requires considerable effort. The chemical approaches for the synthesis of the starting compounds required for further transformations are well known and described. Therefore, we used the corresponding N-R1-2 as intermediates for the synthesis of new 5-(thiophen-3-ylmethyl) -4-R1-1,2,4-triazole-3-thiols appropriate ones were used N-R1-2-(2-(thiophen-3-yl) acetyl) hydrazinocarbothioamide.

Accessing Polycyclic Terpenoids from Zerumbone via Lewis Acid Catalyzed Synthetic Strategies

Synthesis ◽  
2020 ◽  
Vol 52 (14) ◽  
pp. 2045-2064 ◽  
Author(s):  
Puthiyaparambath Sharathna ◽  
Murugan Thulasi Meenu ◽  
Kokkuvayil Vasu Radhakrishnan ◽  
Bhandara Purayil Dhanya ◽  
Greeshma Gopalan ◽  
...  
Keyword(s):  
Natural Products ◽  
Lewis Acid ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Effective Strategy ◽  
Structural Elements ◽  
Nazarov Cyclization ◽  
Active Compounds ◽  
Acid Catalyzed

We herein disclose an effective strategy for the synthesis of [5.3.0] and [6.3.0] fused polycyclic terpenoids, which are important structural elements of natural products and biologically active compounds. The method comprises of Lewis acid catalyzed interrupted Nazarov cyclization of zerumbone derivatives such as zerumbone epoxide, triazole-appended zerumbone, zerumbal, and zerumbenone with a wide substrate scope with different indoles. Zerumbone epoxide furnished [5.3.0] and [6.3.0] fused structurally diverse sesquiterpenoids and all other zerumbone derivatives furnished the [6.3.0] fused motifs.

Developments toward the synthesis and application of 3-hydroxyindanones

2016 ◽  
Vol 14 (38) ◽  
pp. 8895-8910 ◽  
Author(s):  
Tanmoy Chanda ◽  
Maya Shankar Singh
Keyword(s):  
Natural Products ◽  
Functional Materials ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Comprehensive Overview ◽  
Active Compounds ◽  
Drug Candidates

3-Hydroxyindanone is an important scaffold in many natural products, biologically active compounds, and functional materials. This review provides a comprehensive overview of the construction of 3-hydroxyindanone derivatives and their applications towards pharmaceutically promising drug candidates.

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