scholarly journals α-CGRP disrupts amylin fibrillization and regulates insulin secretion: implications on diabetes and migraine

2021 ◽  
Vol 12 (16) ◽  
pp. 5853-5864
Author(s):  
Amber L. H. Gray ◽  
Aleksandra Antevska ◽  
Benjamin A. Link ◽  
Bryan Bogin ◽  
Susan J. Burke ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Insulin Secretion ◽  
Protective Effect ◽  
Human Insulin ◽  
Human Amylin

CGRP concentration is elevated in migraine conditions. The protective effect of migraine against type 2 diabetes is attributed to the ability of CGRP to remodel human amylin aggregation and to suppress the secretion of mouse insulin 2 (the orthologue of human insulin).

scholarly journals Expression and functional assessment of candidate type 2 diabetes susceptibility genes identify four new genes contributing to human insulin secretion

2017 ◽  
Vol 6 (6) ◽  
pp. 459-470 ◽  
Author(s):  
Fatou K. Ndiaye ◽  
Ana Ortalli ◽  
Mickaël Canouil ◽  
Marlène Huyvaert ◽  
Clara Salazar-Cardozo ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Insulin Secretion ◽  
Human Insulin ◽  
Functional Assessment ◽  
Susceptibility Genes ◽  
Diabetes Susceptibility ◽  
New Genes

The Clinical and Economic Effects of Switching Medicare Beneficiaries with Type 2 Diabetes from Analog to Human Insulin

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 4-OR
Author(s):  
JING LUO ◽  
NAZLEEN F. KHAN ◽  
THOMAS MANETTI ◽  
JAMES J. ROSE ◽  
ANI KALOGHLIAN ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Human Insulin ◽  
Economic Effects ◽  
Medicare Beneficiaries

1516-P: A Comparison of the Contributions of Impaired Insulin Secretion and Insulin Resistance to the Development of Type 2 Diabetes in a Japanese Community: The Hisayama Study

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1516-P
Author(s):  
MASAHITO YOSHINARI ◽  
YOICHIRO HIRAKAWA ◽  
JUN HATA ◽  
MAYU HIGASHIOKA ◽  
TAKANORI HONDA ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Insulin Secretion ◽  
Impaired Insulin Secretion ◽  
Impaired Insulin

755-P: A Plant-Based Meal Stimulates Incretin and Insulin Secretion More than an Energy- and Macronutrient-Matched Standard Meal in Type 2 Diabetes: A Randomized Crossover Study

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 755-P
Author(s):  
HANA KAHLEOVA ◽  
ANDREA TURA ◽  
MARTA KLEMENTOVA ◽  
LENKA BELINOVA ◽  
MARTIN HALUZIK ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Insulin Secretion ◽  
Crossover Study ◽  
Standard Meal ◽  
Randomized Crossover Study

110-OR: Type 2 Diabetes (T2D)–Associated TCF7L2 Genetic Variants and Indices of Insulin Secretion and Sensitivity in Individuals at Risk for Type 1 Diabetes (T1D)

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 110-OR
Author(s):  
MARIA J. REDONDO ◽  
MEGAN V. WARNOCK ◽  
LAURA E. BOCCHINO ◽  
SUSAN GEYER ◽  
ALBERTO PUGLIESE ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
At Risk ◽  
Type 1 Diabetes ◽  
Insulin Secretion ◽  
Genetic Variants

Echinops Spp. Polysaccharide B Ameliorates Metabolic Abnormalities in a Rat Model of Type 2 Diabetes Mellitus

2020 ◽  
Vol 19 (1) ◽  
pp. 106-114
Author(s):  
Guang Hao ◽  
Xiaoyu Ma ◽  
Mengru Jiang ◽  
Zhenzhen Gao ◽  
Ying Yang
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Insulin Secretion ◽  
Insulin Receptor ◽  
Skeletal Muscles ◽  
Insulin Receptor Substrate ◽  
Sprague Dawley

This study examined the in vivo effects of Echinops spp. polysaccharide B on type 2 diabetes mellitus in Sprague-Dawley rats. We constructed a type 2 diabetes mellitus Sprague-Dawley rat models by feeding a high-fat and high-sugar diet plus intraperitoneal injection of a small dose of streptozotocin. Using this diabetic rat model, different doses of Echinops polysaccharide B were administered orally for seven weeks. Groups receiving Xiaoke pill and metformin served as positive controls. The results showed that Echinops polysaccharide B treatment normalized the weight and blood sugar levels in the type 2 diabetes mellitus rats, increased muscle and liver glycogen content, improved glucose tolerance, increased insulin secretion, and reduced glucagon and insulin resistance indices. More importantly, Echinops polysaccharide B treatment upregulated the expression of insulin receptor in the liver, skeletal muscles, and pancreas, and significantly improved the expression levels of insulin receptor substrate-2 protein in the liver and pancreas, as well as it increased insulin receptor substrate-1 expression in skeletal muscles. These two proteins play crucial roles in increasing insulin secretion and in controlling type 2 diabetes mellitus. The findings of the present study suggest that Echinops polysaccharide B could improve the status of diabetes in type 2 diabetes mellitus rats, which may be achieved by improving insulin resistance. Our study provides a new insight into the development of a natural drug for the control of type 2 diabetes mellitus.

Kcne2 deletion impairs insulin secretion and causes type 2 diabetes mellitus

2017 ◽  
Vol 31 (6) ◽  
pp. 2674-2685 ◽  
Author(s):  
Soo Min Lee ◽  
Jasmine Baik ◽  
Dara Nguyen ◽  
Victoria Nguyen ◽  
Shiwei Liu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Insulin Secretion
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