scholarly journals Retraction: Self-association of L-periaxin occurs via its acidic domain and NLS2/NLS3, and affects its trafficking in RSC96 cells

RSC Advances ◽  
2021 ◽  
Vol 11 (25) ◽  
pp. 15203-15203
Author(s):  
Yenan Yang ◽  
Min Liang ◽  
Yawei Shi
Keyword(s):  
Acidic Domain ◽  
Self Association

Retraction of ‘Self-association of L-periaxin occurs via its acidic domain and NLS2/NLS3, and affects its trafficking in RSC96 cells’ by Yenan Yang et al., RSC Adv., 2017, 7, 44112–44123, DOI: 10.1039/C7RA06853K

scholarly journals Self-association of L-periaxin occurs via its acidic domain and NLS2/NLS3, and affects its trafficking in RSC96 cells

RSC Advances ◽  
2017 ◽  
Vol 7 (70) ◽  
pp. 44112-44123 ◽  
Author(s):  
Yenan Yang ◽  
Min Liang ◽  
Yawei Shi
Keyword(s):  
Peripheral Nerve ◽  
Schwann Cells ◽  
Acidic Domain ◽  
Associated Proteins ◽  
Self Association

Periaxin (PRX) protein was first identified in myelinating Schwann cells through the screening of cytoskeleton-associated proteins in peripheral nerve myelination.

Aggregated, Conformationally Changed Fibrinogen Exposes the Stimulating Sites for t-PA-Catalysed Plasminogen Activation

1996 ◽  
Vol 75 (02) ◽  
pp. 326-331 ◽  
Author(s):  
Unni Haddeland ◽  
Knut Sletten ◽  
Anne Bennick ◽  
Willem Nieuwenhuizen ◽  
Frank Brosstad
Keyword(s):  
Conformational Changes ◽  
Gel Permeation Chromatography ◽  
Tissue Type ◽  
Plasminogen Activation ◽  
Chromogenic Substrate ◽  
Type Plasminogen Activator ◽  
Gel Permeation ◽  
Self Association ◽  
Fibrin Monomers ◽  
Stimulation Of

SummaryThe present paper shows that conformationally changed fibrinogen can expose the sites Aα-(148-160) and γ-(312-324) involved in stimulation of the tissue-type plasminogen activator (t-PA)-catalysed plasminogen activation. The exposure of the stimulating sites was determined by ELISA using mABs directed to these sites, and was shown to coincide with stimulation of t-PA-catalysed plasminogen activation as assessed in an assay using a chromogenic substrate for plasmin. Gel permeation chromatography of fibrinogen conformationally changed by heat (46.5° C for 25 min) demonstrated the presence of both aggregated and monomeric fibrinogen. The aggregated fibrinogen, but not the monomeric fibrinogen, had exposed the epitopes Aα-(148-160) and γ-(312-324) involved in t-PA-stimulation. Fibrinogen subjected to heat in the presence of 3 mM of the tetrapeptide GPRP neither aggregates nor exposes the rate-enhancing sites. Thus, aggregation and exposure of t-PA-stimulating sites in fibrinogen seem to be related phenomena, and it is tempting to believe that the exposure of stimulating sites is a consequence of the conformational changes that occur during aggregation, or self-association. Fibrin monomers kept in a monomeric state by a final GPRP concentration of 3 mM do not expose the epitopes Aα-(148-160) and γ-(312-324) involved in t-PA-stimulation, whereas dilution of GPRP to a concentration that is no longer anti-polymerizing, results in exposure of these sites. Consequently, the exposure of t-PA-stimulating sites in fibrin as well is due to the conformational changes that occur during selfassociation.

Self-association of insulin. Its pH dependence and effect of plasma

Diabetes ◽  
1987 ◽  
Vol 36 (3) ◽  
pp. 261-264 ◽  
Author(s):  
E. Helmerhorst ◽  
G. B. Stokes
Keyword(s):  
Ph Dependence ◽  
Self Association

Understanding Self-Association and Tubule Formation in Phytosterol-Based Oleogels

2020 ◽  
Author(s):  
Stephen Euston ◽  
Paul Clegg ◽  
George Dalkas ◽  
Andrew Matheson
Keyword(s):  
Tubule Formation ◽  
Self Association

Coadsorption of bulky ions by surfactants. Monomolecular layers of tris(2,2'-bipyridyl)ruthenium(II) complex with sodium lauryl sulphate on glassy carbon, platinium, n-SnO2, and n-Si electrodes

1984 ◽  
Vol 49 (10) ◽  
pp. 2187-2196 ◽  
Author(s):  
Jan Lasovský ◽  
František Grambal ◽  
Miroslav Rypka
Keyword(s):  
Glassy Carbon ◽  
Complex Cation ◽  
Radiant Energy ◽  
Electric Energy ◽  
Sodium Lauryl Sulphate ◽  
Surface Films ◽  
Order Of Magnitude ◽  
Monomolecular Layers ◽  
Self Association ◽  
Semiconductor Electrodes

The electrochemical and photochemical behaviour of tris(2,2'-bipyridyl)ruthenium(II) complex (I) on glassy carbon, platinium, n-SnO2, and n-Si electrodes in the presence of sodium lauryl sulphate (II) was investigated. The surfactant in low concentrations induces self-association of the complex cation and its accumulation in the electrode-solution interface. At the optimum concentrations of sodium lauryl sulphate (cII ~0.6 mmol l-1) and of the complex (cI < 0.1 mmol l-1), monomolecular layers composed of I, II counterions are formed on the electrodes. The formation of the surface films does not depend on the kind of the electrode and improves the sensitivity of the voltammetric determination of I by as much as an order of magnitude. For the semiconductor electrodes, the surface films enhance the efficiency of conversion of radiant energy into electric energy. The effect under study may participate in the photosynthesis of green plants.

scholarly journals Characterization of Native Reversible Self-Association of a Monoclonal Antibody Mediated by Fab-Fab Interaction

2020 ◽  
Vol 109 (1) ◽  
pp. 443-451 ◽  
Author(s):  
Lorenzo Gentiluomo ◽  
Dierk Roessner ◽  
Werner Streicher ◽  
Sujata Mahapatra ◽  
Pernille Harris ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Self Association

Interaction Between Mutations in the suppressor of Hairy wing and modifier of mdg4 Genes of Drosophila melunogaster Affecting the Phenotype of gypsy-Induced Mutations

Genetics ◽  
1996 ◽  
Vol 142 (2) ◽  
pp. 425-436 ◽  
Author(s):  
Pavel Georgiev ◽  
Marina Kozycina
Keyword(s):  
Mutagenic Effect ◽  
Induced Mutations ◽  
Binding Region ◽  
Direct Inhibition ◽  
Amino Terminal ◽  
Acidic Domain ◽  
Complete Inactivation ◽  
Insulation Effect ◽  
Gypsy Retrotransposon ◽  
Carboxy Terminal

Abstract The suppressor of Hairy-wing [su(Hw)] protein mediates the mutagenic effect of the gypsy retrotransposon by repressing the function of transcriptional enhancers located distally from the promoter with respect to the position of the su(Hw)-binding region. Mutations in a second gene, modifier of mdg4, also affect the gypsy-induced phenotype. Two major effects of the mod(mdg4)lul mutation can be distinguished: the interference with insulation by the su(Hw)-binding region and direct inhibition of gene expression that is not dependent on the su(Hw)-binding region position. The mod(mdg4)lul mutation partially suppresses ct6, scD1 and Hw1 mutations, possibly by interfering with the insulation effect of the su(Hw)-binding region. An example of the second effect of mod(mdg4)lul is a complete inactivation of yellow expression in combination with the y  2 allele. Phenotypic analyses of flies with combinations of mod(mdg4)lul and different su(Hw) mutations, or with constructions carrying deletions of the acidic domains of the su(Hw) protein, suggest that the carboxy-terminal acidic domain is important for direct inhibition of yellow transcription in bristles, while the amino-terminal acidic domain is more essential for insulation.

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