scholarly journals New small γ-turn type N-primary amino terminal tripeptide organocatalyst for solvent-free asymmetric aldol reaction of various ketones with aldehydes

RSC Advances ◽  
2021 ◽  
Vol 11 (61) ◽  
pp. 38925-38932
Author(s):  
Rajkumar Thiyagarajan ◽  
Zubeda Begum ◽  
Chigusa Seki ◽  
Yuko Okuyama ◽  
Eunsang Kwon ◽  
...  
Keyword(s):  
Aldol Reaction ◽  
Solvent Free ◽  
Asymmetric Aldol ◽  
Amino Terminal ◽  
Asymmetric Aldol Reaction ◽  
Primary Amino

New small γ-turn type N-primary amino terminal tripeptides were applied for the asymmetric aldol reaction of ketones with aldehydes under neat conditions to afford the chiral aldol products (up to 99%, up to syn : anti/13 : 87 dr, up to 99% ee).

Asymmetric aldol reaction organocatalyzed by bifunctional N-prolyl sulfinamides under solvent-free conditions

RSC Advances ◽  
2014 ◽  
Vol 4 (51) ◽  
pp. 26563-26568 ◽  
Author(s):  
Wen Wan ◽  
Wei Gao ◽  
Guobin Ma ◽  
Lei Ma ◽  
Fan Wang ◽  
...  
Keyword(s):  
Aldol Reaction ◽  
Solvent Free ◽  
Aldol Reactions ◽  
Matching Effect ◽  
Asymmetric Aldol ◽  
Solvent Free Conditions ◽  
Asymmetric Aldol Reaction

Chiral bifunctional N-prolyl sulfinamide and its TFA salts were synthesized and applied in asymmetric aldol reactions under solvent-free conditions. The aldol adducts were obtained with high to excellent yields, enantioselectivities and diastereoselectivities. A matching effect between chiral proline and sulfinamide moieties was observed for the catalysts.

(l)-Prolinamide imidazolium hexafluorophosphate ionic liquid as an efficient reusable organocatalyst for direct asymmetric aldol reaction in solvent-free condition

RSC Advances ◽  
2016 ◽  
Vol 6 (102) ◽  
pp. 100459-100466 ◽  
Author(s):  
Geeta Devi Yadav ◽  
Surendra Singh
Keyword(s):  
Ionic Liquid ◽  
Aldol Reaction ◽  
Solvent Free ◽  
Asymmetric Aldol ◽  
Free Condition ◽  
Solvent Free Condition ◽  
Hydrophobic Ionic Liquid ◽  
Asymmetric Aldol Reaction

We have designed a new hydrophobic ionic liquid derived from bromoester of trans-4-hydroxy-(l)-prolinamide and N-methylimidazole.

The smallest organocatalyst in highly enantioselective direct aldol reaction in wet solvent-free conditions

RSC Advances ◽  
2014 ◽  
Vol 4 (46) ◽  
pp. 24311-24315 ◽  
Author(s):  
Sudipto Bhowmick ◽  
Sunita S. Kunte ◽  
Kartick C. Bhowmick
Keyword(s):  
Amino Acid ◽  
Room Temperature ◽  
Aldol Reaction ◽  
Aromatic Aldehydes ◽  
Solvent Free ◽  
Natural Amino Acid ◽  
Asymmetric Aldol ◽  
Direct Aldol Reaction ◽  
Solvent Free Conditions ◽  
Asymmetric Aldol Reaction

The catalytic efficacy of the smallest organocatalyst, l-proline hydrazide, prepared from a cheaply available natural amino acid, such as l-proline, was studied for the direct asymmetric aldol reaction of various ketones with aromatic aldehydes at room temperature in the presence of several acid additives.

scholarly journals Design of New Amino Tf-Amide Organocatalysts: Environmentally Benign Approach to Asymmetric Aldol Synthesis

Synlett ◽  
2018 ◽  
Vol 30 (04) ◽  
pp. 401-404 ◽  
Author(s):  
Hyo-Jun Lee ◽  
Natarajan Arumugam ◽  
Abdulrahman Almansour ◽  
Raju Kumar ◽  
Keiji Maruoka
Keyword(s):  
Aldol Reaction ◽  
Environmentally Benign ◽  
Chemical Behavior ◽  
Mannich Reactions ◽  
Asymmetric Aldol ◽  
Asymmetric Aldol Reaction ◽  
New Type ◽  
Primary Amino ◽  
Optically Pure

A new type of optically pure primary amino aromatic Tf-amide organocatalyst can be easily prepared from 8-amino-1-tetralone, and its chemical behavior was investigated in the context of asymmetric aldol and Mannich reactions. Most notably, the asymmetric aldol reaction proceeded smoothly in brine.

Design and preparation of a novel prolinamide-based organocatalyst for the solvent-free asymmetric aldol reaction

Tetrahedron ◽  
2020 ◽  
Vol 76 (5) ◽  
pp. 130855 ◽  
Author(s):  
Rafaela de S. Martins ◽  
Mathias P. Pereira ◽  
Pedro P. de Castro ◽  
Fernanda I. Bombonato
Keyword(s):  
Aldol Reaction ◽  
Solvent Free ◽  
Asymmetric Aldol ◽  
Asymmetric Aldol Reaction
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