scholarly journals Preparation, characterization, and biological activity study of thymoquinone-cucurbit[7]uril inclusion complex

RSC Advances ◽  
2022 ◽  
Vol 12 (4) ◽  
pp. 1982-1988
Author(s):  
Lubna Alrawashdeh ◽  
Khaleel I. Assaf ◽  
Walhan Alshaer ◽  
Fadwa Odeh ◽  
Suhair A. Bani-Atta
Keyword(s):  
Aqueous Solution ◽  
Biological Activity ◽  
Inclusion Complex ◽  
Inclusion Complexation

The host–guest inclusion complexation of thymoquinone by cucurbit[7]uril in aqueous solution is established, which results in an enhanced biological activity.

Spectrofluorimetric Study on Inclusion Complexation of 2-Amino-6-fluorobenzothiazole with β-Cyclodextrin

2008 ◽  
Vol 73 (2) ◽  
pp. 147-160 ◽  
Author(s):  
Rajaram Rajamohan ◽  
Sundarajulu Kothai Nayaki ◽  
Meenakshisundaram Swaminathan
Keyword(s):  
Aqueous Solution ◽  
Steady State ◽  
Solid State ◽  
Inclusion Complex ◽  
Inclusion Complexation ◽  
Solid Complex ◽  
Time Resolved Fluorescence ◽  
Sem Images ◽  
Time Resolved ◽  
Ft Ir

The interaction between 2-amino-6-fluorobenzothiazole (AFBT) and β-cyclodextrin (β-CDx) has been investigated in aqueous solution and in the solid state. The stoichiometry and binding constant of the complex between AFBT and β-CDx in solution were determined by steady-state and time-resolved fluorescence spectroscopy. The FT-IR spectral data and SEM images of the solid complex confirmed the formation of inclusion complex. The proton transfer behaviour of AFBT has been investigated in aqueous and β-CDx solutions.

NMR spectroscopy of inclusion complex of d-(-)-chloramphenicol with β-cyclodextrin in aqueous solution

Il Farmaco ◽  
2004 ◽  
Vol 59 (10) ◽  
pp. 835-838 ◽  
Author(s):  
Syed Mashhood Ali ◽  
Fahmeena Asmat ◽  
Arti Maheshwari
Keyword(s):  
Aqueous Solution ◽  
Nmr Spectroscopy ◽  
Inclusion Complex

scholarly journals Inclusion complexation of .BETA.-cyclodextrin with some sulfonamides in aqueous solution.

1978 ◽  
Vol 26 (4) ◽  
pp. 1162-1167 ◽  
Author(s):  
KANETO UEKAMA ◽  
FUMITOSHI HIRAYAMA ◽  
MASAKI OTAGIRI ◽  
YOUKO OTAGIRI ◽  
KEN IKEDA
Keyword(s):  
Aqueous Solution ◽  
Inclusion Complexation ◽  
Beta Cyclodextrin

scholarly journals Molecular Dynamic Simulation Analysis on the Inclusion Complexation of Plumbagin with β-Cyclodextrin Derivatives in Aqueous Solution

Molecules ◽  
2021 ◽  
Vol 26 (22) ◽  
pp. 6784
Author(s):  
Kulpavee Jitapunkul ◽  
Pisanu Toochinda ◽  
Luckhana Lawtrakul
Keyword(s):  
Aqueous Solution ◽  
Slow Release ◽  
Storage Temperature ◽  
Simulation Analysis ◽  
Inclusion Complexation ◽  
Storage Life ◽  
Release Mechanism ◽  
Guest Binding ◽  
Binding Cavity ◽  
Dynamics Simulations

Stable encapsulation of medically active compounds can lead to longer storage life and facilitate the slow-release mechanism. In this work, the dynamic and molecular interactions between plumbagin molecule with β-cyclodextrin (BCD) and its two derivatives, which are dimethyl-β-cyclodextrin (MBCD), and 2-O-monohydroxypropyl-β-cyclodextrin (HPBCD) were investigated. Molecular dynamics simulations (MD) with GLYCAM-06 and AMBER force fields were used to simulate the inclusion complex systems under storage temperature (4 °C) in an aqueous solution. The simulation results suggested that HPBCD is the best encapsulation agent to produce stable host–guest binding with plumbagin. Moreover, the observation of the plumbagin dynamic inside the binding cavity revealed that it tends to orient the methyl group toward the wider rim of HPBCD. Therefore, HPBCD is a decent candidate for the preservation of plumbagin with a promising longer storage life and presents the opportunity to facilitate the slow-release mechanism.

scholarly journals Guest-Host Inclusion Complex Formation of 2-, 3-, and 4-Aminobenzoic Acids with Native and Modified Cyclodextrins

2016 ◽  
Vol 69 ◽  
pp. 10-21 ◽  
Author(s):  
Narayanasamy Rajendiran ◽  
J. Thulasidhasan ◽  
M. Jude Jenita
Keyword(s):  
Inclusion Complex ◽  
Inclusion Complexation ◽  
Aminobenzoic Acid ◽  
Time Resolved ◽  
H Nmr ◽  
Buffer Solutions ◽  
Aminobenzoic Acids ◽  
Modified Cyclodextrins ◽  
Ft Ir ◽  
Uv Visible

The inclusion complexation of 2-aminobenzoic acid (2ABA), 3-aminobenzoic acid (3ABA), and 4-aminobenzoic acid (4ABA) with α-cyclodextrin (α-CD), β-cyclodextrin (β-CD), hydroxypropyl-α-cyclodextrin (HP-α-CD) and hydroxypropyl-β-cyclodextrin (HP-β-CD) were studied in buffer solutions of differentpHs (pH~1 andpH~7) and it was carried out using UV-Visible, steady-state and time-resolved fluorescence. Dual fluorescence was observed for all the compounds in aqueous and CD medium. All the ABAs forms 1:1 inclusion complex at pH ~ 1 solution and mixture of 1:1 and 1:2 inclusion complex at pH ~7. With CDs, dual luminescence appeared at pH ~ 1 indicates, both NH3+and COOH groups are present in the interior of the CDs cavities. FT-IR,1H NMR, results suggest ABAs formed a stable inclusion complex with the CDs.

Evaluation of the phase solubility of inclusion complexes of diisopropylphenol (INN) with hydroxypropyl-β-cyclodextrin

2021 ◽  
pp. 27-32
Author(s):  
Olga Mikhailovna Balakhonova ◽  
Viktoriya Sergeevna Tyukova ◽  
Stanislav Anatolievich Kedik
Keyword(s):  
Aqueous Solution ◽  
Inclusion Complex ◽  
Inclusion Complexes ◽  
Tween 80 ◽  
Phase Solubility ◽  
Cyclodextrin Inclusion ◽  
Solubility Method ◽  
Cyclodextrin Inclusion Complex ◽  
The Stability ◽  
Solubility Profiles

The paper presents the results of a study of the stability of aqueous solutions of inclusion complexes of hydroxypropyl-β-cyclodextrin with diisopropylphenol in various systems by the Higuchi-Connors phase solubility method. The phase solubility profiles for each system corresponding to the AN type are determined graphically, and the stability constants of the resulting inclusion complexes are calculated. An aqueous solution containing 0.2 % Tween 80 and 0.2 % mannitol was selected as the optimal condition for obtaining the hydroxypropyl-β-cyclodextrin inclusion complex with diisopropylphenol.

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