scholarly journals Nanostructured plasmonic chips employing nanopillar and nanoring hole arrays for enhanced sensitivity of SPR-based biosensing

RSC Advances ◽  
2022 ◽  
Vol 12 (2) ◽  
pp. 929-938
Author(s):  
Ajay Kumar Agrawal ◽  
Akanksha Ninawe ◽  
Anuj Dhawan
Keyword(s):  
Plasmonic Sensor ◽  
Kretschmann Configuration ◽  
Enhanced Sensitivity ◽  
Highly Sensitive ◽  
Hole Arrays

Nanostructured plasmonic sensor chips interrogated using the Kretschmann configuration for highly sensitive localized sensing.

Sensitivity Enhancement of Surface Plasmon Resonance Sensor with Two Dimensional Materials Covered on Silver-Nickel Bimetallic Thin Solid Films

2020 ◽  
Vol 18 (10) ◽  
pp. 776-779
Author(s):  
L. Castañeda
Keyword(s):  
2D Materials ◽  
Sensitivity Enhancement ◽  
Thin Solid Films ◽  
Solid Films ◽  
Kretschmann Configuration ◽  
Enhanced Sensitivity ◽  
Resonance Sensor ◽  
Two Dimensional Materials ◽  
Fresnel Equation ◽  
Hybrid Configuration

In this paper a new sensing configuration with enhanced sensitivity utilizing 2D materials on the bimetallic layers of Magnetic Material Ni over Ag for Kretschmann configuration is proposed and analyzed numerically using Fresnel equation and transfer matrix method. Results show that such a hybrid configuration with well optimized thickness of metallic layer and utilization of specific no. of 2D materials can increases the sensitivity as high as 298°/RIU is absorbed for the configuration consist 10 nm of Ni over 40 nm thickness of Ag added with a 2 layers of WSe2.

Comparative study of the highly sensitive plasmonic sensor based on a D-Shaped photonic crystal fiber with silver or gold layers

2021 ◽  
Author(s):  
Bahar Meshginqalam ◽  
Jamal Barvestani
Keyword(s):  
Photonic Crystal ◽  
Comparative Study ◽  
Photonic Crystal Fiber ◽  
Structural Parameters ◽  
Simultaneous Detection ◽  
Plasmonic Sensor ◽  
Plasmonic Material ◽  
Sensor Performance ◽  
Crystal Fiber ◽  
Highly Sensitive

Abstract A highly sensitive D-shaped photonic crystal fiber sensor with circular lattice is proposed for external plasmonic sensing. The proposed design of plasmonic material in a D-shaped form effectively facilitates the excitation of surface plasmons and enhances the sensor performance. As a comparative study, two different plasmonic materials, gold and silver, are applied D-shapely on the fiber and the proposed sensor performance is numerically investigated and evaluated. Moreover, the optimized structural parameters such as air-hole diameters and the thickness of silver and gold layers are selected via simulation results which cause the highest sensitivity of 40000nm/RIU for the gold coated fiber using the wavelength interrogation method. Furthermore, the maximum figure of merit can reach 621.50RIU-1. Analytes with the refractive indices ranging from 1.34 to 1.39 can be detected by double-loss peak that is a more reliable method of simultaneous detection and verification of sensing characteristics. Due to its promising results, the proposed sensor can be widely useful in the area of chemical and biological sensing.

scholarly journals Rapid and Sensitive RT-QuIC Detection of Human Creutzfeldt-Jakob Disease Using Cerebrospinal Fluid

mBio ◽  
2015 ◽  
Vol 6 (1) ◽  
Author(s):  
Christina D. Orrú ◽  
Bradley R. Groveman ◽  
Andrew G. Hughson ◽  
Gianluigi Zanusso ◽  
Michael B. Coulthart ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Protein Misfolding ◽  
Prion Diseases ◽  
Analytical Sensitivity ◽  
Enhanced Sensitivity ◽  
Highly Sensitive ◽  
Jakob Disease ◽  
Misfolding Diseases ◽  
Amyloid Diseases ◽  
Sporadic Cjd

ABSTRACT  Fast, definitive diagnosis of Creutzfeldt-Jakob disease (CJD) is important in assessing patient care options and transmission risks. Real-time quaking-induced conversion (RT-QuIC) assays of cerebrospinal fluid (CSF) and nasal-brushing specimens are valuable in distinguishing CJD from non-CJD conditions but have required 2.5 to 5 days. Here, an improved RT-QuIC assay is described which identified positive CSF samples within 4 to 14 h with better analytical sensitivity. Moreover, analysis of 11 CJD patients demonstrated that while 7 were RT-QuIC positive using the previous conditions, 10 were positive using the new assay. In these and further analyses, a total of 46 of 48 CSF samples from sporadic CJD patients were positive, while all 39 non-CJD patients were negative, giving 95.8% diagnostic sensitivity and 100% specificity. This second-generation RT-QuIC assay markedly improved the speed and sensitivity of detecting prion seeds in CSF specimens from CJD patients. This should enhance prospects for rapid and accurate ante mortem CJD diagnosis. IMPORTANCE A long-standing problem in dealing with various neurodegenerative protein misfolding diseases is early and accurate diagnosis. This issue is particularly important with human prion diseases, such as CJD, because prions are deadly, transmissible, and unusually resistant to decontamination. The recently developed RT-QuIC test allows for highly sensitive and specific detection of CJD in human cerebrospinal fluid and is being broadly implemented as a key diagnostic tool. However, as currently applied, RT-QuIC takes 2.5 to 5 days and misses 11 to 23% of CJD cases. Now, we have markedly improved RT-QuIC analysis of human CSF such that CJD and non-CJD patients can be discriminated in a matter of hours rather than days with enhanced sensitivity. These improvements should allow for much faster, more accurate, and practical testing for CJD. In broader terms, our study provides a prototype for tests for misfolded protein aggregates that cause many important amyloid diseases, such as Alzheimer’s, Parkinson’s, and tauopathies.

scholarly journals Magneto-Impedance Biosensor With Enhanced Sensitivity for Highly Sensitive Detection of Nanomag-D Beads

2013 ◽  
Vol 49 (7) ◽  
pp. 4060-4063 ◽  
Author(s):  
Jagannath Devkota ◽  
Alejandro Ruiz ◽  
Pritish Mukherjee ◽  
Hariharan Srikanth ◽  
Manh-Huong Phan
Keyword(s):  
Sensitive Detection ◽  
Enhanced Sensitivity ◽  
Highly Sensitive ◽  
Highly Sensitive Detection

Reference Flow Injection Analysis of Trace Amounts of Tannin with Inhibited Kinetic Spectrophotometric Detection

2013 ◽  
Vol 838-841 ◽  
pp. 2455-2460
Author(s):  
Lan Yu
Keyword(s):  
Flow Injection ◽  
Inhibitory Effect ◽  
Enhanced Sensitivity ◽  
Response Range ◽  
Reference Flow ◽  
Highly Sensitive ◽  
Relative Standard ◽  
Kinetic Spectrophotometric ◽  
Sulphuric Acid Medium

A simple and highly sensitive reference flow injection inhibited kinetic spectrophotometric method is proposed for the determination of trace tannin in tea and wine samples. The method was based on the enhanced sensitivity of cetylpyridinium bromide on the redox reaction between Eosine Y and KBrO3, and on inhibitory effect of tannin on the same reaction in the sulphuric acid medium. The resulting red complex product was stable in sulphuric acidic medium and has a maximum absorption at 540 nm. The linear response range and detection limit are 0.010-0.45 mg L-1and 4.82μg L-1respectively. The sampling frequency was 20 samples per hour. The relative standard deviation for 11 determinations of 0.10mg L-1tannin acid was 1.78% and values of recovery in the rang of 96.7%-107.3%.The proposed method has been successfully used to determine tannin in tea and wine samples. The results obtained were compared with those provided by the FolinDenis method.

scholarly journals Wearable, stable, highly sensitive hydrogel–graphene strain sensors

2019 ◽  
Vol 10 ◽  
pp. 475-480 ◽  
Author(s):  
Jian Lv ◽  
Chuncai Kong ◽  
Chao Yang ◽  
Lu Yin ◽  
Itthipon Jeerapan ◽  
...  
Keyword(s):  
Wearable Sensors ◽  
Polymer Network ◽  
Graphene Film ◽  
Strain Sensor ◽  
Step Method ◽  
Enhanced Sensitivity ◽  
Highly Sensitive ◽  
The Stability ◽  
Bending Modes ◽  
Different Strains

A stable and highly sensitive graphene/hydrogel strain sensor is designed by introducing glycerol as a co-solvent in the formation of a hydrogel substrate and then casting a graphene solution onto the hydrogel in a simple, two-step method. This hydrogel-based strain sensor can effectively retain water in the polymer network due to the formation of strong hydrogen bonding between glycerol and water. The addition of glycerol not only enhances the stability of the hydrogel over a wider temperature range, but also increases the stretchability of the hydrogel from 800% to 2000%. The enhanced sensitivity can be attributed to the graphene film, whereby the graphene flakes redistribute to optimize the contact area under different strains. The careful design enables this sensor to be used in both stretching and bending modes. As a demonstration, the as-prepared strain sensor was applied to sense the movement of finger knuckles. Given the outstanding performance of this wearable sensor, together with the proposed scalable fabrication method, this stable and sensitive hydrogel strain sensor is considered to have great potential in the field of wearable sensors.

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