scholarly journals Natural deep eutectic solvents as tailored and sustainable media for the extraction of five compounds from compound liquorice tablets and their comparison with conventional organic solvents

RSC Advances ◽  
2021 ◽  
Vol 11 (59) ◽  
pp. 37649-37660
Author(s):  
Jia-ni Dong ◽  
Guo-dong Wu ◽  
Zhi-qiang Dong ◽  
Dan Yang ◽  
Yu-kun Bo ◽  
...  
Keyword(s):  
Organic Solvents ◽  
Levulinic Acid ◽  
Extraction Efficiency ◽  
Antioxidant Activities ◽  
Deep Eutectic Solvents ◽  
Acid System ◽  
Natural Deep Eutectic Solvents ◽  
Extraction Parameters ◽  
Sustainable Media

A 1,4-butanediol–levulinic acid system was selected as a topgallant solvent and extraction parameters were optimized. NADES extracts exhibited higher extraction efficiency and in vitro antioxidant activities than conventional solvent extracts.

scholarly journals Natural Deep Eutectic Solvents for the Extraction of Bioactive Steroidal Saponins from Dioscoreae Nipponicae Rhizoma

Molecules ◽  
2021 ◽  
Vol 26 (7) ◽  
pp. 2079
Author(s):  
Gui-Ya Yang ◽  
Jun-Na Song ◽  
Ya-Qing Chang ◽  
Lei Wang ◽  
Yu-Guang Zheng ◽  
...  
Keyword(s):  
Extraction Efficiency ◽  
Choline Chloride ◽  
Deep Eutectic Solvents ◽  
Molar Ratio ◽  
Macroporous Resin ◽  
Steroidal Saponins ◽  
Solid Ratio ◽  
Natural Deep Eutectic Solvents ◽  
Before And After ◽  
Extraction Parameters

In the present study, a simple and environmentally friendly extraction method based on natural deep eutectic solvents (NADESs) was established to extract four bioactive steroidal saponins from Dioscoreae Nipponicae Rhizoma (DNR). A total of twenty-one types of choline chloride, betaine, and L-proline based NADESs were tailored, and the NADES composed of 1:1 molar ratio of choline chloride and malonic acid showed the best extraction efficiency for the four steroidal saponins compared with other NADESs. Then, the extraction parameters for extraction of steroidal saponins by selected tailor-made NADES were optimized using response surface methodology and the optimal extraction conditions are extraction time, 23.5 min; liquid–solid ratio, 57.5 mL/g; and water content, 54%. The microstructure of the DNR powder before and after ultrasonic extraction by conventional solvents (water and methanol) and the selected NADES were observed using field emission scanning electron microscope. In addition, the four steroidal saponins were recovered from NADESs by D101 macroporous resin with a satisfactory recovery yield between 67.27% and 79.90%. The present research demonstrates that NADESs are a suitable green media for the extraction of the bioactive steroidal saponins from DNR, and have a great potential as possible alternatives to organic solvents for efficiently extracting bioactive compounds from natural products.

scholarly journals Deep Eutectic Solvents for the Extraction of Bioactive Compounds from Natural Sources and Agricultural By-Products

2021 ◽  
Vol 11 (11) ◽  
pp. 4897
Author(s):  
Bárbara Socas-Rodríguez ◽  
M. Vanessa Torres-Cornejo ◽  
Gerardo Álvarez-Rivera ◽  
Jose A. Mendiola
Keyword(s):  
Bioactive Compounds ◽  
Deep Eutectic Solvents ◽  
Extraction Methods ◽  
In Vitro Cytotoxicity ◽  
In Vivo Studies ◽  
Natural Sources ◽  
Natural Deep Eutectic Solvents ◽  
By Products

In this work, a review about the applicability of eutectic solvents, mainly deep eutectic solvents (DES) and natural deep eutectic solvents (NADES), for the extraction of bioactive compounds from natural products has been carried out. These alternative solvents have shown not only to have high extraction yields but also to be environmentally friendly, exhibiting very low or almost no toxicity, compared to conventional organic solvents. The last trends and main extraction methods that have been most widely used in studies using these emerging solvents have been reviewed, as well as the varied natural sources in which they have been used, including agro-food by-products. Besides the toxicity, biodegradability of these solvents is reviewed. Likewise, different reported bioactivity tests have been included, in which extracts obtained with these ecological solvents have been tested from antioxidant activity analysis to in vivo studies with rats, through in vitro cytotoxicity tests.

scholarly journals Assessment of Total Phenolic Content, In Vitro Antioxidant and Antibacterial Activity of Ruta graveolens L. Extracts Obtained by Choline Chloride Based Natural Deep Eutectic Solvents

Plants ◽  
2019 ◽  
Vol 8 (3) ◽  
pp. 69 ◽  
Author(s):  
Valentina Pavić ◽  
Dora Flačer ◽  
Martina Jakovljević ◽  
Maja Molnar ◽  
Stela Jokić
Keyword(s):  
Total Phenolic Content ◽  
Phenolic Content ◽  
Antibacterial Property ◽  
Choline Chloride ◽  
Deep Eutectic Solvents ◽  
Total Phenolic ◽  
Ruta Graveolens ◽  
Gram Negative ◽  
Natural Deep Eutectic Solvents

Rue (R. graveolens) has been an extensively studied medicinal plant due to its rich phytochemicals content, such as furanocoumarins and flavonoids. The aim of this study was to determine the effects of varying extraction conditions on the total phenolic content, the antioxidant and antibacterial property of rue leaves crude extracts using deep eutectic solvents with different water content. These extraction conditions include the temperature and the extraction time. The extract obtained at 30 °C, with 20% water and at 90 min, with 13.3 µg mL−1 concentration, was found to possess the highest total phenolic content (38.24 ± 0.11 mg of GAE g−1 of DM) and the highest antioxidant activity (72.53 ± 0.31%). In this study, the same extract showed the best antibacterial efficiency against all the tested strains, especially gram-negative P. aeruginosa.

scholarly journals Greener Is Better: First Approach for the Use of Natural Deep Eutectic Solvents (NADES) to Extract Antioxidants from the Medicinal Halophyte Polygonum maritimum L.

Molecules ◽  
2021 ◽  
Vol 26 (20) ◽  
pp. 6136
Author(s):  
Iva Rukavina ◽  
Maria João Rodrigues ◽  
Catarina G. Pereira ◽  
Inês Mansinhos ◽  
Anabela Romano ◽  
...  
Keyword(s):  
Radical Scavenging Activity ◽  
Choline Chloride ◽  
Antioxidant Properties ◽  
Radical Scavenging ◽  
Deep Eutectic Solvents ◽  
Acetone Extract ◽  
Dpph Radical ◽  
Dpph Assay ◽  
Natural Deep Eutectic Solvents

In this study, natural deep eutectic solvents (NADES) formed by choline chloride (ChCl), sucrose, fructose, glucose, and xylose, were used to extract antioxidants from the halophyte Polygonum maritimum L. (sea knotgrass) and compared with conventional solvents (ethanol and acetone). NADES and conventional extracts were made by an ultrasound-assisted procedure and evaluated for in vitro antioxidant properties by the radical scavenging activity (RSA) on the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical, oxygen radical absorbance capacity (ORAC), and copper chelating activity (CCA). Samples were profiled by liquid chromatography (LC)-electrospray ionization (ESI)-QTOF-MS analysis. ChCl:fructose was more efficient in the DPPH assay, than the acetone extract. ChCl:sucrose and ChCl:fructose extracts had the highest ORAC when compared with the acetone extract. NADES extracts had higher CCA, than the acetone extract. The phenolic composition of the NADES extracts was less complex than the conventional extracts, but the proportions of major antioxidants, such as flavonols and flavan-3-ols, were similar in all the solvents. Myricitrin was the major flavonoid in all of the samples, while gallic acid was the main phenolic acid in the conventional extracts and present in a greater amount in ChCl:fructose. Results suggest that NADES containing ChCl and sucrose/fructose can replace conventional solvents, especially acetone, in the extraction of antioxidants from sea knotgrass.

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