scholarly journals DIBALH: from known fundamental to an unusual reaction; chemoselective partial reduction of tertiary amides in the presence of esters

RSC Advances ◽  
2021 ◽  
Vol 11 (53) ◽  
pp. 33809-33813
Author(s):  
Yu Jin Heo ◽  
Hyun Tae Kim ◽  
Ashok Kumar Jaladi ◽  
Duk Keun An
Keyword(s):  
Unusual Reaction ◽  
Partial Reduction ◽  
Tertiary Amides

Highly chemoselective partial reduction of tertiary amides to aldehydes over esters are reported with commercial DIBALH. Various aldehydes are synthesized in excellent yields.

Lithium compound catalyzed deoxygenative hydroboration of primary, secondary and tertiary amides

2021 ◽  
Vol 50 (7) ◽  
pp. 2354-2358
Author(s):  
Milan Kumar Bisai ◽  
Kritika Gour ◽  
Tamal Das ◽  
Kumar Vanka ◽  
Sakya S. Sen
Keyword(s):  
Lithium Compound ◽  
Tertiary Amides

A very simple and readily accessible lithium compound has been employed to catalyze the hydroboration of tertiary, secondary, and primary amides to the corresponding amines.

scholarly journals Administration of a CD25-Directed Immunotoxin, LMB-2, to Patients with Metastatic Melanoma Induces a Selective Partial Reduction in Regulatory T Cells In Vivo

2007 ◽  
Vol 179 (7) ◽  
pp. 4919-4928 ◽  
Author(s):  
Daniel J. Powell ◽  
Aloisio Felipe-Silva ◽  
Maria J. Merino ◽  
Mojgan Ahmadzadeh ◽  
Tamika Allen ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Metastatic Melanoma ◽  
Partial Reduction

The Preparation of Specifically Deuterated trans- Cinnamyl Alcohol and trans- Cinnamic Acid

1973 ◽  
Vol 51 (13) ◽  
pp. 2102-2104 ◽  
Author(s):  
Donald G. Lee ◽  
James R. Brownridge
Keyword(s):  
Cinnamic Acid ◽  
Triple Bond ◽  
Lithium Aluminum Hydride ◽  
Aluminum Hydride ◽  
Lithium Aluminum ◽  
Cinnamyl Alcohol ◽  
Partial Reduction ◽  
Work Up

The reduction of ethyl phenylpropiolate by lithium aluminum hydride results in partial reduction of the triple bond to give trans-cinnamyl alcohol. If ethyl phenylpropiolate is reduced by LiAlD4 followed by work-up with acetone and H2O the product is the specifically labeled compound, trans-3-phenyl-2-propen-1-ol-1,1,2-d3. If the ester is reduced with LiAlH4 followed by work-up with acetone-d6 and D2O the product is trans-3-phenyl-2-propen-1-ol-O,3-d2. Oxidation of these two products by sodium ruthenate leads to formation of trans-cinnamic acid-α-d and trans-cinnamic acid-β-d, respectively.

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