scholarly journals Bacterial virulence factors: a target for heterocyclic compounds to combat bacterial resistance

RSC Advances ◽  
2021 ◽  
Vol 11 (58) ◽  
pp. 36459-36482
Author(s):  
Rehab H. Abd El-Aleam ◽  
Riham F. George ◽  
Hanan H. Georgey ◽  
Hamdy M. Abdel-Rahman
Keyword(s):  
Virulence Factors ◽  
Heterocyclic Compounds ◽  
Bacterial Resistance ◽  
Bacterial Virulence ◽  
Microbial Resistance

This review presents an overview of different heterocyclic compounds that act as anti-virulence agents in order to overcome microbial resistance.

Interference of quorum sensing regulated bacterial virulence factors and biofilms by Plumbago zeylanica extract

2021 ◽  
Author(s):  
Faizan Abul Qais ◽  
Iqbal Ahmad ◽  
Fohad Mabood Husain ◽  
Suliman Y. Alomar ◽  
Naushad Ahmad ◽  
...  
Keyword(s):  
Quorum Sensing ◽  
Virulence Factors ◽  
Bacterial Virulence ◽  
Plumbago Zeylanica

scholarly journals RND Efflux Systems Contribute to Resistance and Virulence of Aliarcobacter butzleri

Antibiotics ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 823
Author(s):  
Cristiana Mateus ◽  
Ana Rita Nunes ◽  
Mónica Oleastro ◽  
Fernanda Domingues ◽  
Susana Ferreira
Keyword(s):  
Oxidative Stress ◽  
Human Serum ◽  
Ethidium Bromide ◽  
Biofilm Formation ◽  
Bacterial Resistance ◽  
Efflux Pumps ◽  
Bacterial Virulence ◽  
Relative Fitness ◽  
Mutant Strains

Aliarcobacter butzleri is an emergent enteropathogen that can be found in a range of environments. This bacterium presents a vast repertoire of efflux pumps, such as the ones belonging to the resistance nodulation cell division family, which may be associated with bacterial resistance, as well as virulence. Thus, this work aimed to evaluate the contribution of three RND efflux systems, AreABC, AreDEF and AreGHI, in the resistance and virulence of A. butzleri. Mutant strains were constructed by inactivation of the gene that encodes the inner membrane protein of these systems. The bacterial resistance profile of parental and mutant strains to several antimicrobials was assessed, as was the intracellular accumulation of the ethidium bromide dye. Regarding bacterial virulence, the role of these three efflux pumps on growth, strain fitness, motility, biofilm formation ability, survival in adverse conditions (oxidative stress and bile salts) and human serum and in vitro adhesion and invasion to Caco-2 cells was evaluated. We observed that the mutants from the three efflux pumps were more susceptible to several classes of antimicrobials than the parental strain and presented an increase in the accumulation of ethidium bromide, indicating a potential role of the efflux pumps in the extrusion of antimicrobials. The mutant strains had no bacterial growth defects; nonetheless, they presented a reduction in relative fitness. For the three mutants, an increase in the susceptibility to oxidative stress was observed, while only the mutant for AreGHI efflux pump showed a relevant role in bile stress survival. All the mutant strains showed an impairment in biofilm formation ability, were more susceptible to human serum and were less adherent to intestinal epithelial cells. Overall, the results support the contribution of the efflux pumps AreABC, AreDEF and AreGHI of A. butzleri to antimicrobial resistance, as well as to bacterial virulence.

scholarly journals Tackling Virulence of Pseudomonas aeruginosa by the Natural Furanone Sotolon

Antibiotics ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 871
Author(s):  
Mohammed F. Aldawsari ◽  
El-Sayed Khafagy ◽  
Ahmed Al Saqr ◽  
Ahmed Alalaiwe ◽  
Hisham A. Abbas ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Virulence Factors ◽  
Bacterial Infections ◽  
Therapeutic Agent ◽  
Bacterial Resistance ◽  
Inhibitory Concentration ◽  
Bacterial Biofilm ◽  
Resistant Bacteria ◽  
Resistance Development

The bacterial resistance development due to the incessant administration of antibiotics has led to difficulty in their treatment. Natural adjuvant compounds can be co-administered to hinder the pathogenesis of resistant bacteria. Sotolon is the prevailing aromatic compound that gives fenugreek its typical smell. In the current work, the anti-virulence activities of sotolon on Pseudomonas aeruginosa have been evaluated. P. aeruginosa has been treated with sotolon at sub-minimum inhibitory concentration (MIC), and production of biofilm and other virulence factors were assessed. Moreover, the anti-quorum sensing (QS) activity of sotolon was in-silico evaluated by evaluating the affinity of sotolon to bind to QS receptors, and the expression of QS genes was measured in the presence of sotolon sub-MIC. Furthermore, the sotolon in-vivo capability to protect mice against P. aeruginosa was assessed. Significantly, sotolon decreased the production of bacterial biofilm and virulence factors, the expression of QS genes, and protected mice from P. aeruginosa. Conclusively, the plant natural substance sotolon attenuated the pathogenicity of P. aeruginosa, locating it as a plausible potential therapeutic agent for the treatment of its infections. Sotolon can be used in the treatment of bacterial infections as an alternative or adjuvant to antibiotics to combat their high resistance to antibiotics.

Host and Bacterial Virulence Factors Predisposing to Emphysematous Pyelonephritis

2005 ◽  
Vol 46 (3) ◽  
pp. 432-439 ◽  
Author(s):  
Chin-Chung Tseng ◽  
Jiunn-Jong Wu ◽  
Ming-Cheng Wang ◽  
Lien-I. Hor ◽  
Yen-Hsiu Ko ◽  
...  
Keyword(s):  
Virulence Factors ◽  
Bacterial Virulence ◽  
Emphysematous Pyelonephritis

Inhibition of bacterial virulence factors of foodborne pathogens by paprika (Capsicum annuum L.) extracts

Food Control ◽  
2021 ◽  
pp. 108568
Author(s):  
Rocío Daniela Inés Molina ◽  
Rodrigo Campos-Silva ◽  
Myriam Anabel Díaz ◽  
Alexandre José Macedo ◽  
María Amparo Blázquez ◽  
...  
Keyword(s):  
Capsicum Annuum ◽  
Virulence Factors ◽  
Foodborne Pathogens ◽  
Bacterial Virulence ◽  
Capsicum Annuum L

Role of Bacterial Virulence Factors and Host Factors in the Outcome of Escherichia coli Bacteraemia

2000 ◽  
Vol 19 (4) ◽  
pp. 312-316 ◽  
Author(s):  
T. A. M. Hekker ◽  
A. B. J. Groeneveld ◽  
A. M. Simoons-Smit ◽  
P. de Man ◽  
H. Connell ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Virulence Factors ◽  
Bacterial Virulence ◽  
Host Factors

Liposomes as novel anti-infectives targeting bacterial virulence factors?

2015 ◽  
Vol 13 (5) ◽  
pp. 531-533 ◽  
Author(s):  
Samareh Azeredo da Silveira ◽  
Antonio Perez
Keyword(s):  
Virulence Factors ◽  
Bacterial Virulence

scholarly journals The Pseudomonas syringae avrRpt2 Gene Contributes to Virulence on Tomato

2005 ◽  
Vol 18 (7) ◽  
pp. 626-633 ◽  
Author(s):  
Melisa T. S. Lim ◽  
Barbara N. Kunkel
Keyword(s):  
Pseudomonas Syringae ◽  
Virulence Factors ◽  
Host Defense ◽  
Virulence Gene ◽  
Bacterial Virulence ◽  
Host Tissue ◽  
Native Strain ◽  
Phytopathogenic Bacteria ◽  
Gram Negative ◽  
Mutant Derivative

In order to cause disease on plants, gram-negative phytopathogenic bacteria introduce numerous virulence factors into the host cell in order to render host tissue more hospitable for pathogen proliferation. The mode of action of such bacterial virulence factors and their interaction with host defense pathways remain poorly understood. avrRpt2, a gene from Pseudomonas syringae pv. tomato JL1065, has been shown to promote the virulence of heterologous P. syringae strains on Arabidopsis thaliana. However, the contribution of avrRpt2 to the virulence of JL1065 has not been examined previously. We show that a mutant derivative of JL1065 that carries a disruption in avrRpt2 is impaired in its ability to cause disease on tomato (Lycopersicon esculentum), indicating that avrRpt2 also acts as a virulence gene in its native strain on a natural host. The virulence activity of avrRpt2 was detectable on tomato lines that are defective in either ethylene perception or the accumulation of salicylic acid, but could not be detected on a tomato mutant insensitive to jasmonic acid. The enhanced virulence conferred by the expression of avrRpt2 in JL1065 was not associated with the suppression of several defense-related genes induced during the infection of tomato.

scholarly journals The Rab-binding Profiles of Bacterial Virulence Factors during Infection

2016 ◽  
Vol 291 (11) ◽  
pp. 5832-5843 ◽  
Author(s):  
Ernest C. So ◽  
Gunnar N. Schroeder ◽  
Danielle Carson ◽  
Corinna Mattheis ◽  
Aurélie Mousnier ◽  
...  
Keyword(s):  
Virulence Factors ◽  
Bacterial Virulence
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