scholarly journals Evaluation of histone deacetylase inhibitor substituted zinc and indium phthalocyanines for chemo- and photodynamic therapy

RSC Advances ◽  
2021 ◽  
Vol 11 (55) ◽  
pp. 34963-34978
Author(s):  
Başak Aru ◽  
Aysel Günay ◽  
Gülderen Yanıkkaya Demirel ◽  
Ayşe Gül Gürek ◽  
Devrim Atilla
Keyword(s):  
Breast Cancer ◽  
Photodynamic Therapy ◽  
Endothelial Cell ◽  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitor ◽  
Breast Cancer Cell Lines ◽  
Deacetylase Inhibitor ◽  
Anti Cancer ◽  
Human Endothelial Cell Line ◽  
Mcf 7

3-Hydroxypyridin-2-thione bearing zinc and indium phthalocyanine derivatives, as photosensitizer agents have been synthesized and evaluated for their anti-cancer efficacy on two breast cancer cell lines, MDA-MB-231 and MCF-7 as well as a human endothelial cell line, HUVEC.

scholarly journals Histone deacetylase inhibitor- and PMA-induced upregulation of PMCA4b enhances Ca2+ clearance from MCF-7 breast cancer cells

Cell Calcium ◽  
2014 ◽  
Vol 55 (2) ◽  
pp. 78-92 ◽  
Author(s):  
Karolina Varga ◽  
Katalin Pászty ◽  
Rita Padányi ◽  
Luca Hegedűs ◽  
Jean-Philippe Brouland ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitor ◽  
Breast Cancer Cells ◽  
Deacetylase Inhibitor ◽  
Mcf 7

scholarly journals Antagonistic Interaction between Histone Deacetylase Inhibitor: Cambinol and Cisplatin—An Isobolographic Analysis in Breast Cancer In Vitro Models

2021 ◽  
Vol 22 (16) ◽  
pp. 8573
Author(s):  
Marta Hałasa ◽  
Jarogniew J. Łuszczki ◽  
Magdalena Dmoszyńska-Graniczka ◽  
Marzena Baran ◽  
Estera Okoń ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Histone Deacetylase ◽  
Cell Lines ◽  
Histone Deacetylase Inhibitor ◽  
Pharmacological Interaction ◽  
Isobolographic Analysis ◽  
Antagonistic Interaction ◽  
Deacetylase Inhibitor ◽  
Anti Cancer

Breast cancer (BC) is the leading cause of death in women all over the world. Currently, combined chemotherapy with two or more agents is considered a promising anti-cancer tool to achieve better therapeutic response and to reduce therapy-related side effects. In our study, we demonstrated an antagonistic effect of cytostatic agent-cisplatin (CDDP) and histone deacetylase inhibitor: cambinol (CAM) for breast cancer cell lines with different phenotypes: estrogen receptor positive (MCF7, T47D) and triple negative (MDA-MB-231, MDA-MB-468). The type of pharmacological interaction was assessed by an isobolographic analysis. Our results showed that both agents used separately induced cell apoptosis; however, applying them in combination ameliorated antiproliferative effect for all BC cell lines indicating antagonistic interaction. Cell cycle analysis showed that CAM abolished cell cycle arrest in S phase, which was induced by CDDP. Additionally, CAM increased cell proliferation compared to CDDP used alone. Our data indicate that CAM and CDDP used in combination produce antagonistic interaction, which could inhibit anti-cancer treatment efficacy, showing importance of preclinical testing.

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