scholarly journals Novel hydrophobic deep eutectic solvent for vortex-assisted liquid phase microextraction of common acaricides in fruit juice followed by HPLC-UV determination

RSC Advances ◽  
2021 ◽  
Vol 11 (48) ◽  
pp. 30102-30108
Author(s):  
Setareh Rostami-Javanroudi ◽  
Masoud Moradi ◽  
Kiomars Sharafi ◽  
Nazir Fattahi
Keyword(s):  
Hydrogen Bond ◽  
Liquid Phase ◽  
Fruit Juice ◽  
Deep Eutectic Solvent ◽  
Deep Eutectic Solvents ◽  
Straight Chain ◽  
Hydrogen Bond Acceptor ◽  
Liquid Phase Microextraction ◽  
Different Types ◽  
Hydrogen Bond Donors

In this research, several novel hydrophobic deep eutectic solvents (DESs) were prepared using methyltrioctylammonium chloride (MTOAC) as the hydrogen bond acceptor (HBA) and different types of straight chain alcohols as hydrogen bond donors (HBDs).

The extraction of pyrethroid insecticides in juice and tea beverages by liquid-phase microextraction using deep eutectic solvents

2019 ◽  
Vol 11 (38) ◽  
pp. 4923-4930 ◽  
Author(s):  
Heng Qian ◽  
Chaoran Liu ◽  
Qian Yang ◽  
Xinya Liu ◽  
Haixiang Gao ◽  
...  
Keyword(s):  
Hydrogen Bond ◽  
Liquid Phase ◽  
Porous Ceramic ◽  
Deep Eutectic Solvents ◽  
Hydrogen Bond Donor ◽  
Hydrogen Bond Acceptor ◽  
Liquid Phase Microextraction ◽  
Pyrethroid Insecticides ◽  
Beverage Samples ◽  
Pyrethroid Pesticides

Deep eutectic solvents (DESs), a mixture of hydrogen bond acceptor and hydrogen bond donor compounds, were dispersed in a porous ceramic film for the determination of pyrethroid pesticides in juice and tea beverage samples using liquid-phase microextraction.

scholarly journals Densities and Refractive Indices of Potassium Carbonate -Based Deep Eutectic Solvents with Dual Hydrogen Bond Donors at Several Temperatures (293.15 to 343.15 K)

2017 ◽  
Author(s):  
Hosein Ghaedi ◽  
Muhammad Ayoub ◽  
Suriati Sufian ◽  
Azmi Mohd Shariff ◽  
Bhajan Lal
Keyword(s):  
Hydrogen Bond ◽  
Refractive Index ◽  
Potassium Carbonate ◽  
Deep Eutectic Solvent ◽  
Deep Eutectic Solvents ◽  
Molar Ratio ◽  
Hydrogen Bond Acceptor ◽  
Molar Ratios ◽  
Experimental Density ◽  
Hydrogen Bond Donors

Deep eutectic solvents (DESs) are known as tunable solvents. It is possible to prepare ternary deep eutectic solvent (TDES) are used for desired purpose by selecting the suitable molar ratio and components of mixture. Therefore, four DESs and two TDESs were prepared in this work. DESs and TDESs were prepared with potassium carbonate (PC) as a hydrogen bond acceptor (HBA) and three hydrogen bond donors (HBDs) such as glycerol (GL), ethylene glycol (EG) and 2-amino-2methyl-1-3-propanediol (AMPD) known as a hindered amine (HA). Binary DESs were PC-GL with molar ratios 1:10 and 1:16 and PC-EG with the same molar ratios. TDES were prepared by adding AMPD in binary DESs such as PC-GL-AMPD 1:16:1 and PC-EG-AMPD 1:10:1. The experimental density and refractive index of all DESs and TDESs were measured at the temperature of 293.15 to 343.15 K with an interval of 5 K. The effect of temperature, molar ratio and alkyl chain length on the properties was investigated. The molar volumes and isobaric thermal expansion were calculated using experimental density data. The experimental refractive index data was used to derive the specific refraction, molar refraction, free molar volume, electronic polarization, polarizability constant and internal pressure at several temperatures.

A lighter-than-water deep eutectic-solvent-based dispersive liquid-phase microextraction method in a U-shaped homemade device

2018 ◽  
Vol 42 (12) ◽  
pp. 10100-10110 ◽  
Author(s):  
Abolghasem Jouyban ◽  
Mir Ali Farajzadeh ◽  
Mohammad Reza Afshar Mogaddam
Keyword(s):  
Liquid Phase ◽  
Fruit Juice ◽  
Deep Eutectic Solvent ◽  
Liquid Phase Microextraction ◽  
Vegetable Samples ◽  
Glass Filter

A new microextraction method, termed glass-filter-based dispersive liquid-phase microextraction using a lighter-than-water deep eutectic solvent, was developed for the extraction and preconcentration of different classes of pesticides from fruit juice and vegetable samples.

scholarly journals A brief review on eutectic mixture and its role in pharmaceutical field

2020 ◽  
Vol 11 (3) ◽  
pp. 3017-3023
Author(s):  
Balakrishnan I ◽  
Jawahar N ◽  
Senthil Venkatachalam ◽  
Debosmita Datta
Keyword(s):  
Drug Delivery ◽  
Hydrogen Bond ◽  
Deep Eutectic Solvent ◽  
Eutectic Mixture ◽  
Deep Eutectic Solvents ◽  
Hydrogen Bond Donor ◽  
Liquid Form ◽  
Hydrogen Bond Acceptor ◽  
Pharmaceutical Industries ◽  
Natural Deep Eutectic Solvent

Eutectic mixture (EM) is as a mixture of more than one substance that does not interact individually to create a new entity but in a particular ratio that exhibits a lower range of melting point than it had in individual. EM should be formulated in such a way that it should have major advantages in pharmaceutical industries. EM can be a mixture of Active Pharmaceutical Ingredients (APIs), or different ratios of APIs and excipients, or various excipients. Deep eutectic solvents containing APIs (API-DES) considered as an innovative approach to form different APIs in the liquid state. This new approach of liquid form is versatile and plays an important role in drug delivery. The selection of ideal hydrogen bond-donor (HBD) and hydrogen bond-acceptor (HBA) is an essential parameter. Ionic liquids (IL), derivatives of deep eutectic solvents (DES) have got much attention since it can replace harmful organic solvent by their extraordinary properties. Therapeutic deep eutectic solvents (THEDESs) are considered to be an exceptional option in the advancement of biomedicine. This can be utilized for improvising drug solubility, bioavailability as well as drug permeation through the skin. Natural deep eutectic solvent (NADES) can be considered as an alternate option, replacing harsh solvents. It has special characteristics of better biodegradability and biocompatibility. These NADES mainly used to separate and purification of natural compounds. This review focuses on the eutectic mixture and its application in the area of drug delivery systems, and pharmaceutical and pharmacological fields.

An Effective Acid–Base-Induced Liquid–Liquid Microextraction Based on Deep Eutectic Solvents for Determination of Testosterone and Methyltestosterone in Milk

2020 ◽  
Vol 58 (9) ◽  
pp. 880-886
Author(s):  
Xiao Li ◽  
Tao Yuan ◽  
Ting Zhao ◽  
Xiaomei Wu ◽  
Yaling Yang
Keyword(s):  
Hydrogen Bond ◽  
Hydrochloric Acid ◽  
High Performance ◽  
Deep Eutectic Solvent ◽  
Deep Eutectic Solvents ◽  
Hydrogen Bond Donor ◽  
Acid Base ◽  
Hydrogen Bond Acceptor ◽  
Liquid Microextraction

Abstract An environmentally friendly method for the determination of testosterone and methyltestosterone by acid–base-induced deep eutectic solvents liquid–liquid microextraction (DES-ABLLME) combining with high-performance liquid chromatography was established. The deep eutectic solvent (DES) consisting of menthol:lauric acid:decanoic acid (3:1:1) can act as both hydrogen bond donor and hydrogen bond acceptor. In this approach, ammonia solution (NH3•H2O) is used as an emulsifier to react with DESs in the extraction process to generate salt and form milky white solution, achieving high extraction efficiency. Hydrochloric acid was used as a phase separator to change the emulsification state and promote the separation of extraction agent from water phase. A series of parameters were optimized including the volume of DES and the emulsifying agent, glucose concentration as well as hydrochloric acid volume. The method was linear in the range 0.5–100 μg mL−1 with a correlation coefficient (R) of 0.9999, and the limits of detection were 0.067 and 0.2 μg mL−1 for testosterone and methyltestosterone, respectively. This method was applied to analyze testosterone and methyltestosterone in milk samples, and the recoveries were between 89.2 and 108.2%.

A study of bacterial cellulose confined ionic liquid and deep eutectic solvent gel materials

2020 ◽  
Author(s):  
◽  
Chip Joseph II Smith
Keyword(s):  
Hydrogen Bond ◽  
Bacterial Cellulose ◽  
Carbon Capture ◽  
Deep Eutectic Solvent ◽  
Deep Eutectic Solvents ◽  
Strong Hydrogen Bond ◽  
Hydrogen Bond Donor ◽  
Hydrogen Bond Acceptor ◽  
University Of Missouri ◽  
Analyte Detection

[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI--COLUMBIA AT REQUEST OF AUTHOR.] Pollutants have become more prevalent in the air, water, and ground, necessitating the development of technologies that would help, limit, reverse, monitor, measure, and recycle prevalent pollutants. Ionic liquids (ILs), or molten salts that are liquid at or below 100[degrees]C, as well as deep eutectic solvents (DESs), a mixture of a hydrogen bond donor with a strong hydrogen bond acceptor that remains liquid upon cooling, have been popularized as greener alternatives in industry. These liquids tend to have large electrochemical and thermal windows, a very small vapor pressure, and can be fine-tuned for many applications. The liquid state of ILs and DESs makes them quite useful in their application but complicates their handling. Ionogels and eutectogels enable the liquid-like dynamics of these solvents while adding a pseudo-solid like character that makes for ease of handling. Herein, a new group of confined ILs and DESs within a cellulosic matrix called bacterial cellulose iono/eutecto gels are produced that are shown to be applicable to analyte detection and are studied for a better understanding of the dynamics within the gel. These intriguing gels are flexible, transparent, size-tuneable, shape-tuneable, amenable to incorporation of dyes or other functional material, and capable of confining 99 wt.% of a solvent with little leakage from the gel. These materials affect the crystallinity of cellulose little, while the liquid presents a diffusional change that stems from restructuring of the fluid. These gels are capable of detection of ammonia, hydrogen sulfide, and temperature. Given their properties, iono/eutecto gels offer use in applications, such as electrochemical devices, wound healing, drug delivery, and carbon capture/separation membranes.

scholarly journals Controlled release of pharmaceutical agents using eutectic modified gelatin

2021 ◽  
Author(s):  
Wanwan Qu ◽  
Idrees B. Qader ◽  
Andrew P. Abbott
Keyword(s):  
Hydrogen Bond ◽  
Carboxylic Acids ◽  
Quaternary Ammonium ◽  
Transdermal Delivery ◽  
Deep Eutectic Solvent ◽  
Deep Eutectic Solvents ◽  
Quaternary Ammonium Salts ◽  
Ammonium Salts ◽  
Delivery Mode ◽  
Hydrogen Bond Acceptor

AbstractDeep eutectic solvent (DES) is a class of ionic liquids, consisting of a mixture generally formed by combining hydrogen bond donors (HBDs) such as alcohols, amides and carboxylic acids with various quaternary ammonium salts. The decrease in melting points of the constituents is due to the charge delocalization during formation of hydrogen bonding between the hydrogen bond acceptor with the hydrogen bond donor. This can be considered one of the main reasons for increasing solubility and absorption of DESs. Most active pharmaceutical ingredients (APIs) have polar functional groups containing amide, carboxylic acid, alcohol or quaternary ammonium groups. These tend to increase the melting point of the compounds, but they can be used to form eutectic mixtures. While this concept has previously used, the combination of quaternary ammonium salts with amides, carboxylic acids and alcohols can result in large depressions of freezing points and so-called deep eutectic solvents are formed. DESs mix readily with water and so could increase the uptake of APIs. In this study, pharmaceutical deep eutectic solvents (PDESs) are formulated from 3 APIs: imipramine HCl, ascorbic acid and catechol. These PDESs were used to plasticise gelatine. It is shown that the materials formed can be used to increase the rate of API uptake via both oral and transdermal delivery modes. Thus, the concentration of the PDESs in solution reaches the maximum before the pure drugs. Particularly for catechol, after 1 s, the dissolution of the PDESs was more than twice that of the pure drug. Moreover, the transdermal delivery mode uptake of the PDES based on imipramine HCl from the patch after 15 min was found to be 65% compared with just imipramine HCl which released only 20%. Graphical abstract

scholarly journals pH, Viscosity of Hydrophobic Based Natural Deep Eutectic Solvents and the Effect of Curcumin Solubility in it

2021 ◽  
Vol 11 (6) ◽  
pp. 14620-14633
Keyword(s):  
Hydrogen Bond ◽  
Room Temperature ◽  
Water Solubility ◽  
Deep Eutectic Solvent ◽  
Deep Eutectic Solvents ◽  
Molar Ratio ◽  
Hydrogen Bond Donor ◽  
Hydrogen Bond Acceptor ◽  
Natural Deep Eutectic Solvents ◽  
Self Association

Turmeric contains curcumin as one of the active constituents, which gives yellow color and possesses lots of pharmacological actions. Even though curcumin has lots of pharmacological actions till now, it has not been approved as a medicine due to its low water solubility, permeability, and poor bioavailability. Deep eutectic solvent (DES) can be prepared by simply mixing two or more solid components, [among the two one is hydrogen bond donor (HBD) and another is hydrogen bond acceptor (HBA)] at a definite molar ratio where the solid components by self-association converted into a liquid at room temperature (RT). Natural deep eutectic solvents (NADES) are a specific subgroup of DES containing primary plant-based metabolites such as organic acids, alcohols, amino acids, or sugars. In this work, natural hydrophobic DESs were prepared with Camphor, Menthol, and Thymol. This was prepared from different ratios of Menthol:Thymol 1:1 to 1:5 and 1:1 to 5:1 (MT-DES); Camphor:Thymol 1:1 to 1:5 and 1:1 to 5:1 (CT-NADES); Camphor:Menthol 1:1 to 1:5 and 1:1 to 2:1 (CM-NADES). The pH and viscosity of prepared DESs were determined with the help of a digital pH meter and Brookfield viscometer. The solubility of curcumin in different NADESs was determined at room temperature (RT) to higher temperatures. The formation of different clear DES was obtained with slight heat. There was no difference in pH for the NADESs prepared without and with heat. Regarding the viscosity CM-DES (1:1) showed less viscosity when compared to other NADESs. The solubility of curcumin was found to be nearly double when it was dissolved in NADES for 1 hr at 35-40°C compared to 48 h stirring at 500 rotations per minute (rpm) at RT. Among different NADESs, curcumin solubility was found to be more in CM (1:1) ratio when compared to other NADESs.

Sign in / Sign up

Export Citation Format

Share Document