scholarly journals Water-promoted dehydrative coupling of 2-aminopyridines in heptane via a borrowing hydrogen strategy

RSC Advances ◽  
2021 ◽  
Vol 11 (37) ◽  
pp. 23144-23150
Author(s):  
Taku Nakayama ◽  
Hidemasa Hikawa ◽  
Shoko Kikkawa ◽  
Isao Azumaya
Keyword(s):  
Coupling Reaction ◽  
Direct Amination ◽  
Borrowing Hydrogen ◽  
Novel Strategy

We describe a novel strategy for the water-promoted dehydrative coupling reaction in heptane, which offers a sustainable direct amination of alcohols.

Visible-Light-Promoted Direct Amination of Phenols via Oxidative Cross-Dehydrogenative Coupling Reaction

2016 ◽  
Vol 18 (14) ◽  
pp. 3326-3329 ◽  
Author(s):  
Yating Zhao ◽  
Binbin Huang ◽  
Chao Yang ◽  
Wujiong Xia
Keyword(s):  
Visible Light ◽  
Coupling Reaction ◽  
Direct Amination ◽  
Dehydrogenative Coupling

Direct Amination of Isohexides via Borrowing Hydrogen Methodology: Regio- and Stereoselective Issues

2020 ◽  
Vol 2020 (5) ◽  
pp. 599-608
Author(s):  
Florian Bahé ◽  
Lucie Grand ◽  
Elise Cartier ◽  
Maïwenn Jacolot ◽  
Sylvie Moebs-Sanchez ◽  
...  
Keyword(s):  
Direct Amination ◽  
Borrowing Hydrogen

Synthesis of Indoline-2,3-diones by Radical Coupling of Indolin-2-ones with tert-Butyl Hydroperoxide

Synlett ◽  
2017 ◽  
Vol 29 (02) ◽  
pp. 215-218 ◽  
Author(s):  
Wei-Wei Ying ◽  
Wen-Ming Zhu ◽  
Hongze Liang ◽  
Wen-Ting Wei
Keyword(s):  
Coupling Reaction ◽  
Metal Catalyst ◽  
Butyl Hydroperoxide ◽  
Alkyl Radicals ◽  
Tert Butyl ◽  
Radical Coupling ◽  
Tert Butyl Hydroperoxide ◽  
Radical Coupling Reaction ◽  
Efficient Route ◽  
Novel Strategy

A novel strategy has been developed for the synthesis of indoline-2,3-diones through a metal-free radical-coupling reaction. Alkyl radicals derived from indolin-2-ones through a radical-transfer reaction combine with the tert-butylhydroperoxy radical readily generated from commercially available tert-butyl hydroperoxide to afford 3-(tert-­butylperoxy)indolin-2-one intermediates that can be further transformed into indoline-2,3-diones under air. This strategy provides a ­simple and efficient route to the construction of a C=O bond without the use of any metal catalyst or base.

scholarly journals A fully enzymatic method for site-directed spin labeling of long RNA

2014 ◽  
Vol 42 (15) ◽  
pp. e117-e117 ◽  
Author(s):  
Isabelle Lebars ◽  
Bertrand Vileno ◽  
Sarah Bourbigot ◽  
Philippe Turek ◽  
Philippe Wolff ◽  
...  
Keyword(s):  
Coupling Reaction ◽  
Spin Labeling ◽  
In Vitro Transcription ◽  
Enzymatic Method ◽  
Paramagnetic Resonance ◽  
T4 Rna Ligase ◽  
Labeled Rna ◽  
Site Directed Spin Labeling ◽  
Novel Strategy

Abstract Site-directed spin labeling is emerging as an essential tool to investigate the structural and dynamical features of RNA. We propose here an enzymatic method, which allows the insertion of a paramagnetic center at a specific position in an RNA molecule. The technique is based on a segmental approach using a ligation protocol with T4 RNA ligase 2. One transcribed acceptor RNA is ligated to a donor RNA in which a thio-modified nucleotide is introduced at its 5′-end by in vitro transcription with T7 RNA polymerase. The paramagnetic thiol-specific reagent is subsequently attached to the RNA ligation product. This novel strategy is demonstrated by introducing a paramagnetic probe into the 55 nucleotides long RNA corresponding to K-turn and Specifier Loop domains from the Bacillus subtilis tyrS T-Box leader RNA. The efficiency of the coupling reaction and the quality of the resulting spin-labeled RNA were assessed by Mass Spectrometry, Electron Paramagnetic Resonance (EPR) and Nuclear Magnetic Resonance (NMR). This method enables various combinations of isotopic segmental labeling and spin labeling schemes, a strategy that will be of particular interest to investigate the structural and dynamical properties of large RNA complexes by NMR and EPR spectroscopies.

scholarly journals A novel strategy for stabilization of sub-nanometric Pd colloids on kryptofix functionalized MCM-41: nanoengineered material for Stille coupling transformation

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hassan Alamgholiloo ◽  
Nader Noroozi Pesyan ◽  
Sadegh Rostamnia
Keyword(s):  
Catalytic Activity ◽  
Large Scale ◽  
Coupling Reaction ◽  
Vital Role ◽  
Metal Particles ◽  
Stille Coupling ◽  
Coupling Transformation ◽  
Novel Strategy ◽  
Average Size ◽  
Mcm 41

AbstractThe stabilization of sub-nanometric metal particles (< 1 nm) with suitable distribution remained challenging in the catalytic arena. Herein, an intelligent strategy was described to anchoring and stabilizing sub-nanometric Pd colloids with an average size of 0.88 nm onto Kryptofix 23 functionalized MCM-41. Then, the catalytic activity of Pd@Kryf/MCM-41 was developed in Stille coupling reaction with a turnover frequency (TOF) value of 247 h−1. The findings demonstrate that porous MCM-41 structure and high-affinity Kryptofix 23 ligand toward adsorption of Pd colloids has a vital role in stabilizing the sub-nanometric particles and subsequent catalytic activity. Overall, these results suggest that Pd@Kryf/MCM-41 is a greener, more suitable option for large-scale applications and provides new insights into the stabilization of sub-nanometric metal particles.

scholarly journals Amination of β-hydroxyl acid esters via cooperative catalysis enables access to bio-based β-amino acid esters

2019 ◽  
Vol 2 (1) ◽  
Author(s):  
Anastasiia Afanasenko ◽  
Tao Yan ◽  
Katalin Barta
Keyword(s):  
Amino Acid ◽  
Value Added ◽  
Building Blocks ◽  
Amino Acid Esters ◽  
Materials Synthesis ◽  
Direct Amination ◽  
Free Construction ◽  
Borrowing Hydrogen ◽  
Hydroxyl Acid ◽  
Acid Esters

Abstract β-amino acid esters are important scaffolds in medicinal chemistry and valuable building blocks for materials synthesis. Surprisingly, the waste-free construction of such moieties from readily available or renewable starting materials has not yet been addressed. Here we report on a robust and versatile method for obtaining β-amino acid esters by direct amination of β-hydroxyl acid esters via the borrowing hydrogen methodology using a cooperative catalytic system that comprises a homogeneous ruthenium catalyst and an appropriate Brønsted acid additive. This method allows for the direct amination of esters of 3-hydroxypropionic acid, a top value-added bio-based platform chemical, opening a simple route to access β-amino acid esters from a range of renewable polyols including sugars and glycerol.

n-Bu4NI-catalyzed direct amination of ethers with aryl tetrazoles and triazoles via cross-dehydrogenative coupling reaction

2015 ◽  
Vol 5 (5) ◽  
pp. 2891-2896 ◽  
Author(s):  
Liang Wang ◽  
Kai-qiang Zhu ◽  
Wen-ting Wu ◽  
Qun Chen ◽  
Ming-yang He
Keyword(s):  
Coupling Reaction ◽  
Direct Amination ◽  
Metal Free ◽  
Dehydrogenative Coupling ◽  
System P

An efficient, metal-free protocol for direct amination of ethers with aryl tetrazoles and triazoles has been developed using the TBAI/TBHP system.

Palladium-catalyzed diastereoselective cross-coupling of two aryl halides via C–H activation: synthesis of chiral eight-membered nitrogen heterocycles

2021 ◽  
Vol 57 (23) ◽  
pp. 2939-2942 ◽  
Author(s):  
Cang Cheng ◽  
Xiang Zuo ◽  
Dongdong Tu ◽  
Bin Wan ◽  
Yanghui Zhang
Keyword(s):  
Nitrogen Heterocycles ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Aryl Halides ◽  
Cross Coupling Reaction ◽  
Palladium Catalyzed ◽  
Novel Strategy

The diastereoselective cross-coupling reaction of two aryl halides has been developed through C–H activation. The reaction represents a novel strategy for the construction of chiral eight-membered nitrogen heterocycles.

The Collaborative Network Approach: a model for advancing patient-centric research for Castleman disease and other rare diseases

2019 ◽  
Vol 3 (1) ◽  
pp. 97-105
Author(s):  
Mary Zuccato ◽  
Dustin Shilling ◽  
David C. Fajgenbaum
Keyword(s):  
Rare Diseases ◽  
Treatment Options ◽  
Castleman Disease ◽  
High Impact ◽  
Collaborative Network ◽  
Network Approach ◽  
Grant Applications ◽  
Research Questions ◽  
Novel Strategy ◽  
Patient Centric

Abstract There are ∼7000 rare diseases affecting 30 000 000 individuals in the U.S.A. 95% of these rare diseases do not have a single Food and Drug Administration-approved therapy. Relatively, limited progress has been made to develop new or repurpose existing therapies for these disorders, in part because traditional funding models are not as effective when applied to rare diseases. Due to the suboptimal research infrastructure and treatment options for Castleman disease, the Castleman Disease Collaborative Network (CDCN), founded in 2012, spearheaded a novel strategy for advancing biomedical research, the ‘Collaborative Network Approach’. At its heart, the Collaborative Network Approach leverages and integrates the entire community of stakeholders — patients, physicians and researchers — to identify and prioritize high-impact research questions. It then recruits the most qualified researchers to conduct these studies. In parallel, patients are empowered to fight back by supporting research through fundraising and providing their biospecimens and clinical data. This approach democratizes research, allowing the entire community to identify the most clinically relevant and pressing questions; any idea can be translated into a study rather than limiting research to the ideas proposed by researchers in grant applications. Preliminary results from the CDCN and other organizations that have followed its Collaborative Network Approach suggest that this model is generalizable across rare diseases.

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