scholarly journals Profiling single-cell level phagocytic activity distribution with blood lactate levels

RSC Advances ◽  
2021 ◽  
Vol 11 (35) ◽  
pp. 21315-21322
Author(s):  
Kurt Wagner ◽  
Muhammad A. Sami ◽  
Corey Norton ◽  
Jonathan McCoy ◽  
Umer Hassan
Keyword(s):  
Single Cell ◽  
Blood Lactate ◽  
Phagocytic Activity ◽  
Single Cell Level ◽  
Cell Level ◽  
Activity Distribution ◽  
Lactate Levels ◽  
The Relationship ◽  
Cell Data ◽  
Blood Lactate Levels

Investigating the relationship between neutrophil phagocytic activity and blood lactate levels by employing single-cell data.

scholarly journals Laser cleavable probes for in situ multiplexed glycan detection by single cell mass spectrometry

2019 ◽  
Vol 10 (47) ◽  
pp. 10958-10962 ◽  
Author(s):  
Jing Han ◽  
Xi Huang ◽  
Huihui Liu ◽  
Jiyun Wang ◽  
Caiqiao Xiong ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Drug Resistance ◽  
Single Cell ◽  
Cell Mass ◽  
Ionization Efficiency ◽  
Single Cell Level ◽  
Cell Level ◽  
Cell Mass Spectrometry ◽  
The Relationship

A single-cell MS approach for multiplexed glycan detection to investigate the relationship between drug resistance and glycans at a single-cell level and quantify multiple glycans, overcoming the limit of low ionization efficiency of glycans.

scholarly journals How Criticality of Gene Regulatory Networks Affects the Resulting Morphogenesis under Genetic Perturbations

2018 ◽  
Vol 24 (2) ◽  
pp. 85-105 ◽  
Author(s):  
Hyobin Kim ◽  
Hiroki Sayama
Keyword(s):  
Single Cell ◽  
Gene Regulatory Networks ◽  
Regulatory Networks ◽  
Single Cell Level ◽  
Cell Level ◽  
Genetic Perturbations ◽  
Gene Regulatory ◽  
Seed Cell ◽  
Complex Features ◽  
The Relationship

Whereas the relationship between criticality of gene regulatory networks (GRNs) and dynamics of GRNs at a single-cell level has been vigorously studied, the relationship between the criticality of GRNs and system properties at a higher level has not been fully explored. Here we aim at revealing a potential role of criticality of GRNs in morphogenesis, which is hard to uncover through the single-cell-level studies, especially from an evolutionary viewpoint. Our model simulated the growth of a cell population from a single seed cell. All the cells were assumed to have identical intracellular GRNs. We induced genetic perturbations to the GRN of the seed cell by adding, deleting, or switching a regulatory link between a pair of genes. From numerical simulations, we found that the criticality of GRNs facilitated the formation of nontrivial morphologies when the GRNs were critical in the presence of the evolutionary perturbations. Moreover, the criticality of GRNs produced topologically homogeneous cell clusters by adjusting the spatial arrangements of cells, which led to the formation of nontrivial morphogenetic patterns. Our findings correspond to an epigenetic viewpoint that heterogeneous and complex features emerge from homogeneous and less complex components through the interactions among them. Thus, our results imply that highly structured tissues or organs in morphogenesis of multicellular organisms might stem from the criticality of GRNs.

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