scholarly journals Unsymmetrical pentamethine cyanines for visualizing physiological acidities from the whole-animal to the cellular scale with pH-responsive deep-red fluorescence

RSC Advances ◽  
2021 ◽  
Vol 11 (29) ◽  
pp. 17871-17879
Author(s):  
Yicheng Wang ◽  
Zuhai Lei ◽  
Cong Wang ◽  
Chong Cao ◽  
Jiayi Hu ◽  
...  
Keyword(s):  
Ph Responsive ◽  
Red Fluorescence

Unsymmetrical pentamethine cyanine fluorophores were developed and used to visualize physiological acidities from the whole-animal to the cellular scale with pH-responsive deep-red fluorescence.

Phospha-fluorescein: a red-emissive fluorescein analogue with high photobleaching resistance

2016 ◽  
Vol 52 (6) ◽  
pp. 1120-1123 ◽  
Author(s):  
Aiko Fukazawa ◽  
Shinji Suda ◽  
Masayasu Taki ◽  
Eriko Yamaguchi ◽  
Marek Grzybowski ◽  
...  
Keyword(s):  
Phosphine Oxide ◽  
Ph Responsive ◽  
Red Fluorescence

Phospha-fluorescein, a phosphine oxide-containing fluorescein analogue, with pH-responsive red fluorescence as well as high photobleaching resistance, was synthesized.

scholarly journals Highly swelling pH-responsive microgels for dual mode near infra-red fluorescence reporting and imaging

2020 ◽  
Vol 2 (9) ◽  
pp. 4261-4271
Author(s):  
Mingning Zhu ◽  
Dongdong Lu ◽  
Qing Lian ◽  
Shanglin Wu ◽  
Wenkai Wang ◽  
...  
Keyword(s):  
Photoluminescence Spectroscopy ◽  
Ph Responsive ◽  
Dual Mode ◽  
Red Fluorescence ◽  
Infra Red

Near infra-red fluorescent pH-responsive microgels provide two methods for remotely reporting swelling changes using photoluminescence spectroscopy and enable imaging in both cells and tissue.

Nanostructures for pH-sensitive Drug Delivery and Magnetic Resonance Contrast Enhancement Systems

2018 ◽  
Vol 25 (25) ◽  
pp. 3036-3057 ◽  
Author(s):  
Xiao Sun ◽  
Guilong Zhang ◽  
Zhengyan Wu
Keyword(s):  
Drug Delivery ◽  
Magnetic Resonance ◽  
Drug Release ◽  
Contrast Enhancement ◽  
General Strategy ◽  
Ph Responsive ◽  
Physicochemical Changes ◽  
Magnetic Resonance Contrast ◽  
Resonance Contrast ◽  
Magnetic Resonance Contrast Enhancement

According to the differences of microenvironments between tumors and healthy tissues, if the anticancer drugs or magnetic resonance contrast agents (MRCAs) can be controlled to precisely match physiological needs at targeted tumor sites, it is expected to acquire better therapeutic efficacy and more accurate diagnosis. Over the decade, stimuli-responsive nanomaterials have been a research hotspot for cancer treatment and diagnosis because they show many excellent functions, such as in vivo imaging, combined targeting drug delivery and systemic controlled release, extended circulation time, etc. Among the various stimuli nanosystems, pH-stimuli mode is regarded as the most general strategy because of solid tumors acidosis. When exposed to weakly acidic tumor microenvironment, pH-responsive nanoplatforms can generate physicochemical changes for their structure and surface characteristics, causing drug release or contrast enhancement. In this review, we focused on the designs of various pH-responsive nanoplatforms and discussed the mechanisms of controlled drug release or switch on-off in MRCAs. This review also discussed the efficacy of cellular internalization for these nanoplatforms via endocytosis of acidic tumor cell. Meanwhile, nanoplatforms response to acidic intracellular pH (such as endosome, lysosome) are discussed, along with approaches for improving drug release performance and magnetic resonance contrast enhancement. A greater understanding of these pH-responsive nanoplatforms will help design more efficient nanomedicine to address the challenges encountered in conventional diagnosis and chemotherapy.

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