scholarly journals Palladium-catalyzed one-pot synthesis of 2-substituted quinazolin-4(3H)-ones from o-nitrobenzamide and alcohols

RSC Advances ◽  
2021 ◽  
Vol 11 (22) ◽  
pp. 13119-13123
Author(s):  
Ke Wang ◽  
Hao Chen ◽  
Xinyan Dai ◽  
Xupeng Huang ◽  
Zhiqiang Feng
Keyword(s):  
Hydrogen Transfer ◽  
One Pot ◽  
One Pot Synthesis ◽  
Palladium Catalyzed ◽  
High Yields

Palladium-catalyzed 2-substituted quinazolin-4(3H)-one formation from readily available o-nitrobenzamides and alcohols using hydrogen transfer is described. Various quinazolin-4(3H)-ones were obtained in good to high yields.

Convenient One-Pot Synthesis of 9H-Carbazoles by Microwave Irradiation Employing a Green Palladium-Based Nanocatalyst

Synthesis ◽  
2021 ◽  
Author(s):  
Darío C. Gerbino ◽  
H. Sebastián Steingruber ◽  
Pamela Mendioroz ◽  
María A. Volpe
Keyword(s):  
Microwave Irradiation ◽  
Direct Synthesis ◽  
Reaction Times ◽  
One Pot ◽  
One Pot Synthesis ◽  
Ligand Free ◽  
Palladium Catalyzed ◽  
Scalable Synthesis ◽  
The One ◽  
High Yields

AbstractAn efficient palladium-catalyzed tandem reaction for the one-pot synthesis of 9H-carbazoles under microwave irradiation is developed. This approach involves a sequential Buchwald–Hartwig amination and a direct arylation from affordable and inexpensive anilines and 1,2-dihaloarenes. For the development of this purpose, a novel and magnetically recoverable palladium nanocatalyst supported on a green biochar under ligand-free conditions is used. Compared to other existing palladium-based protocols, the present synthetic methodology shows a drastic reduction in reaction times and excellent compatibility with different functional groups allowing to obtain a small library of 9H-carbazoles in high yields and with good regioselectivity. This procedure represents the first example in the direct synthesis of carbazoles using a heterogeneous palladium nanocatalyst from commercial precursors. To examine the application of this protocol, a direct and scalable synthesis of the bioactive carbazole alkaloid clausenalene from commercially available starting materials is described.

Palladium catalyzed domino reaction of 1,4-disubstituted 1,2,3-triazoles via double C–H functionalization: one-pot synthesis of triazolo[1,5-f]phenanthridines

RSC Advances ◽  
2016 ◽  
Vol 6 (49) ◽  
pp. 43638-43647 ◽  
Author(s):  
Avnish Kumar ◽  
Sundar S. Shinde ◽  
Dharmendra Kumar Tiwari ◽  
Balasubramanian Sridhar ◽  
Pravin R. Likhar
Keyword(s):  
Domino Reaction ◽  
One Pot ◽  
One Pot Synthesis ◽  
Palladium Catalyzed ◽  
High Yields ◽  
Facile Route

A palladium catalyzed domino reaction of 1,4-disubstituted triazoles involving homo- and heterocondensation is presented. The approach provides a simple, straight forward and a facile route to access triazolo[1,5-f]phenanthridines in high yields.

An Expeditious One-Pot Three-Component Synthesis of 4-Aryl-3,4-dihydrobenzo[g] quinoline-2,5,10(1H)-triones under Green Conditions

2020 ◽  
Vol 23 (23) ◽  
pp. 2626-2634
Author(s):  
Saiedeh Kamalifar ◽  
Hamzeh Kiyani
Keyword(s):  
Reaction Medium ◽  
Meldrum's Acid ◽  
Meldrum’S Acid ◽  
One Pot ◽  
One Pot Synthesis ◽  
Substituted Benzaldehydes ◽  
High Yields ◽  
First Time ◽  
Green Conditions

: An efficient and facial one-pot synthesis of 4-aryl-3,4-dihydrobenzo[g]quinoline- 2,5,10(1H)-triones was developed for the first time. The process proceeded via the three-component cyclocondensation of 2-amino-1,4-naphthoquinone with Meldrum’s acid and substituted benzaldehydes under green conditions. The fused 3,4-dihydropyridin-2(1H)- one-ring naphthoquinones have been synthesized with good to high yields in refluxing ethanol as a green reaction medium. This protocol is simple and effective as well as does not involve the assistance of the catalyst, additive, or hazardous solvents.

Novel One-pot Synthesis of Pyranocarbazole Derivatives via an Isocyanide-based Three-component Reaction

2020 ◽  
Vol 17 ◽  
Author(s):  
Visarapu Malathi ◽  
Pedavenkatagari Narayana Reddy ◽  
Pannala Padmaja
Keyword(s):  
Efficient Method ◽  
Atom Economy ◽  
Reaction Conditions ◽  
One Pot ◽  
Catalyst Free ◽  
One Pot Synthesis ◽  
Three Component Reaction ◽  
High Yields

Abstract:: An efficient method has been developed for the synthesis of new pyrano[3,2-c] and pyrano[3,2-a]carbazole de-rivatives via a three component reaction of 4-hydroxycarbazole or 2-hydroxycarbazole, isocyanides, and dialkylacetylenedi-carboxylates. Noteworthy features of this protocol include mild reaction conditions, catalyst-free, high atom-economy and high yields.

scholarly journals A New and Efficient One-pot Synthesis of Trialkyl 6-tert-Butylamino-2H-pyran-2-one-3,4,5-tricarboxylates

1999 ◽  
Vol 23 (6) ◽  
pp. 368-369
Author(s):  
Issa Yavari ◽  
Abbas Ali Esmaili ◽  
Sakineh Asghari ◽  
Hamid Reza Bijanzadeh
Keyword(s):  
One Pot ◽  
Tert Butyl ◽  
Dialkyl Acetylenedicarboxylates ◽  
One Pot Synthesis ◽  
High Yields

The highly reactive 1:1 intermediate produced in the reaction between tert-butyl isocyanide and dialkyl acetylenedicarboxylates is trapped by dialkyl 2-bromomalonates to yield the title compounds in fairly high yields.

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