scholarly journals Seasonal dynamics of the phenolic constituents of the cones and leaves of oriental Thuja (Platycladus orientalis L.) reveal their anti-inflammatory biomarkers

RSC Advances ◽  
2021 ◽  
Vol 11 (40) ◽  
pp. 24624-24635
Author(s):  
Reham S. Darwish ◽  
Hala M. Hammoda ◽  
Doaa A. Ghareeb ◽  
Ali S. A. Abdelhamid ◽  
Fathallah M. Harraz ◽  
...  
Keyword(s):  
Seasonal Dynamics ◽  
Inflammatory Biomarkers ◽  
Inflammatory Activity ◽  
Platycladus Orientalis ◽  
Phenolic Constituents ◽  
Anti Inflammatory

In this study, the seasonal dynamics of the flavonoids in the cones and leaves of oriental Thuja (Platycladus orientalis L. Franco) as well as the in vitro anti-inflammatory activity of their extracts were investigated.

scholarly journals Investigation of Photoprotective, Anti-Inflammatory, Antioxidant Capacities and LC–ESI–MS Phenolic Profile of Astragalus gombiformis Pomel

Foods ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 1937
Author(s):  
Sabrina Lekmine ◽  
Samira Boussekine ◽  
Salah Akkal ◽  
Antonio Ignacio Martín-García ◽  
Ali Boumegoura ◽  
...  
Keyword(s):  
Protein Denaturation ◽  
Antioxidant Properties ◽  
High Capacity ◽  
Inflammatory Activity ◽  
Protection Factor ◽  
Esi Ms ◽  
Phenolic Constituents ◽  
Anti Inflammatory ◽  
Skin Conditions

Plant-derived compounds have recently been gaining popularity as skincare factors due to their ability to absorb ultraviolet radiations and their anti-inflammatory, and antioxidant properties. In this light, this work aimed to evaluate in vitro the pharmacological activities of the butanolic extract prepared from the aerial parts of Astragalus gombiformis Pomel, an endemic species to southern Algeria. The sun protection factor was used to assess the photoprotective effect (SPF), the protein denaturation method to determine the anti-inflammatory activity, and brine shrimp nauplii and OxHLIA assay, respectively, to assess the cytotoxicity and antioxidant capacity of A. gombiformis. In addition, LC–ESI–MS analysis was employed for the characterization of the phenolic constituents of A. gombiformis. The results showed that A. gombiformis had high capacity for absorbing UV radiations with an SPF of 37.78 ± 0.85 and significant anti-inflammatory activity with a percentage inhibition of 75.38% which is close to that of diclofenac and ketoprofen. In addition, A. gombiformis was found to have effective cytotoxicity against Artemia nauplii with a DC50 value of about 44.7 µg/mL, but a weak hemolytic effect against human erythrocytes. LC–ESI–MS results detected the presence of 17 phenolic compounds with a predominance of cirsiliol, silymarin, quercitrin (quercetin-3-O-rhamnoside), and kaempferol. Taken together, these results suggest that A. gombiformis extract could be used as a skincare agent in cosmetic formulations, providing excellent antioxidant and anti-inflammatory protection, allowing the treatment of skin conditions, as well as a pharmaceutical agent with multidimensional applications.

RP-HPLC Estimation of Flavonol Derivatives and Phenolic Acids in Capsicum annuum L. and their Correlation with In Vitro Anti-Inflammatory Activity

2020 ◽  
Vol 21 (2) ◽  
pp. 149-157
Author(s):  
Zahra Iqbal ◽  
Ausaf Ahmad ◽  
Ziyaul Haque ◽  
Mohammed S. Khan ◽  
Mohd S. Khan ◽  
...  
Keyword(s):  
Capsicum Annuum ◽  
Phenolic Acids ◽  
Inflammatory Activity ◽  
Significant Activity ◽  
Strong Positive Correlation ◽  
Rp Hplc ◽  
Phenolic Constituents ◽  
Anti Inflammatory ◽  
Flavonol Derivatives

Background: Flavonol derivative and phenolic acids derived from the plants function as free radical scavengers, reducing agents, and quenchers for the formation of singlet oxygen. Flavonoids and phenolic constituents also play an important role in various human diseases and disorders primarily through modulation of inflammatory responses. Objective: To estimate the Flavonol Derivatives (FD) and phenolic acids (PA) in Capsicum annuum (CA) and other important phytochemicals having an anti-inflammatory effect. Method: In the present study, FD and PA were estimated in CA and in vitro anti-inflammatory activity (pilot study) was determined and correlation was established. Results: The results were found to be significant using RP-HPLC. FD and PA were found to be 0.0659±0.0058 and 0.0862±0.0.0134 mg/gram dry weight, respectively. For in vitro anti-inflammatory activity, the inhibition of albumin denaturation and antiproteinase activity was found to be maximum in Quercetin (QE) with 98.230±1.589% and 59.906±1.529%, respectively. Heat-induced hemolysis of erythrocytes was found to be maximum in salicylic acid (SA) (71.830±2.838%). Hypotonicity-induced hemolysis showed significant activity with QE (76.770±3.475%). Lipoxygenase and cyclooxygenase inhibition was found to be maximum in QE with 56.930±4.069% and 61.660±3.135%, respectively. Conclusion: A strong positive correlation of 0.9 was observed between the extract of CA and standard QE and SA against the anti-inflammatory activity. Therefore, the role of FD and PA has been postulated to be an active phytochemical of CA accountable for its anti-inflammatory activity. However further work is desirable to fully elucidate the phytochemicals responsible for their anti-inflammatory activity and to develop better herbal drug formulations.

In vitro anti-inflammatory activity of extracts from seeds of some Nigella species

Planta Medica ◽  
2007 ◽  
Vol 73 (09) ◽  
Author(s):  
P Landa ◽  
P Marsik ◽  
T Vanek ◽  
L Kokoska
Keyword(s):  
Inflammatory Activity ◽  
Anti Inflammatory

In Vitro Anti-inflammatory Activity of Selected Japanese Higher Basidiomycetes Mushrooms

2008 ◽  
Vol 10 (1) ◽  
pp. 49-53 ◽  
Author(s):  
Nitaro Maekawa ◽  
Esameldin E. Elgorashi ◽  
Hiroshi Satoh
Keyword(s):  
Inflammatory Activity ◽  
Anti Inflammatory

Synthesis and anti-inflammatory activity of novel steroidal chalcones with 3β-pregnenolone ester derivatives in RAW 264.7 cells in vitro

Steroids ◽  
2021 ◽  
pp. 108830
Author(s):  
Xiaorui Cai ◽  
Fei Sha ◽  
Chuanyi Zhao ◽  
Zhiwei Zheng ◽  
Shulin Zhao ◽  
...  
Keyword(s):  
Inflammatory Activity ◽  
Raw 264.7 Cells ◽  
Raw 264.7 ◽  
Anti Inflammatory

scholarly journals Phytochemical Analysis, Antioxidant and Anti-Inflammatory Activity of Calyces from Physalis peruviana

2014 ◽  
Vol 9 (11) ◽  
pp. 1934578X1400901 ◽  
Author(s):  
Reina M. Toro ◽  
Diana M. Aragón ◽  
Luis F. Ospina ◽  
Freddy A. Ramos ◽  
Leonardo Castellanos
Keyword(s):  
Antioxidant Activities ◽  
Folk Medicine ◽  
Ethanolic Extract ◽  
Inflammatory Activity ◽  
Phytochemical Analysis ◽  
Physalis Peruviana ◽  
Edema Model ◽  
Anti Inflammatory ◽  
Bio Assay

Physalis peruviana calyces are used extensively in folk medicine. The crude ethanolic extract and some fractions of calyces were evaluated in order to explore antioxidant and anti-inflammatory activities. The anti-inflammatory activity was evaluated by the TPA-induced ear edema model. The antioxidant in vitro activity was measured by means of the superoxide and nitric oxide scavenging activity of the extracts and fractions. The butanolic fraction was found to be promising due to its anti-inflammatory and antioxidant activities. Therefore, a bio-assay guided approach was employed to isolate and identify rutin (1) and nicotoflorin (2) from their NMR spectroscopic and MS data. The identification of rutin in calyces of P. peruviana supports the possible use of this waste material for phytotherapeutic, nutraceutical and cosmetic preparations.

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