scholarly journals The effect of 2D tungsten disulfide nanoparticles on Lewis lung carcinoma cells in vitro

RSC Advances ◽  
2021 ◽  
Vol 11 (27) ◽  
pp. 16142-16150
Author(s):  
D. L. Kolesnik ◽  
O. N. Pyaskovskaya ◽  
O. P. Gnatyuk ◽  
V. V. Cherepanov ◽  
S. O. Karakhim ◽  
...  
Keyword(s):  
Lung Carcinoma ◽  
Lewis Lung Carcinoma ◽  
Cytotoxic Effect ◽  
Carcinoma Cells ◽  
Lewis Lung ◽  
Cytostatic Effect ◽  
Lung Carcinoma Cells ◽  
Lewis Lung Carcinoma Cells ◽  
Blue Spectral Region

WS2 2D nanoparticles show no cytotoxic and/or cytostatic effect on Lewis lung carcinoma cells after one day incubation. Only after two days incubation we registered cytotoxic effect. Cells incubated with 2D WS2 nanoparticles have luminescence in the blue spectral region.

DMNQ S-53 induces apoptosis and inhibits the growth of Lewis lung carcinoma cells in vitro and in vivo

2006 ◽  
Vol 1 (1) ◽  
pp. 73-79 ◽  
Author(s):  
Jae-Ho Lee ◽  
Eun-Ok Lee ◽  
Hyo-Jung Lee ◽  
Kwan-Hyun Kim ◽  
Kyoo-Seok Ahn ◽  
...  
Keyword(s):  
Lung Carcinoma ◽  
Lewis Lung Carcinoma ◽  
Carcinoma Cells ◽  
Lewis Lung ◽  
Lung Carcinoma Cells ◽  
Lewis Lung Carcinoma Cells

scholarly journals Nanocomplex of Berberine with C60 Fullerene Is a Potent Suppressor of Lewis Lung Carcinoma Cells Invasion In Vitro and Metastatic Activity In Vivo

Materials ◽  
2021 ◽  
Vol 14 (20) ◽  
pp. 6114
Author(s):  
Iryna Horak ◽  
Svitlana Prylutska ◽  
Iryna Krysiuk ◽  
Serhii Luhovskyi ◽  
Oleksii Hrabovsky ◽  
...  
Keyword(s):  
Lung Carcinoma ◽  
Lewis Lung Carcinoma ◽  
Carcinoma Cells ◽  
C60 Fullerene ◽  
Lewis Lung ◽  
Invasion Potential ◽  
Lung Carcinoma Cells ◽  
Lewis Lung Carcinoma Cells

Effective targeting of metastasis is considered the main problem in cancer therapy. The development of herbal alkaloid Berberine (Ber)-based anticancer drugs is limited due to Ber’ low effective concentration, poor membrane permeability, and short plasma half-life. To overcome these limitations, we used Ber noncovalently bound to C60 fullerene (C60). The complexation between C60 and Ber molecules was evidenced with computer simulation. The aim of the present study was to estimate the effect of the free Ber and C60-Ber nanocomplex in a low Ber equivalent concentration on Lewis lung carcinoma cells (LLC) invasion potential, expression of epithelial-to-mesenchymal transition (EMT) markers in vitro, and the ability of cancer cells to form distant lung metastases in vivo in a mice model of LLC. It was shown that in contrast to free Ber its nanocomplex with C60 demonstrated significantly higher efficiency to suppress invasion potential, to downregulate the level of EMT-inducing transcription factors SNAI1, ZEB1, and TWIST1, to unblock expression of epithelial marker E-cadherin, and to repress cancer stem cells-like markers. More importantly, a relatively low dose of C60-Ber nanocomplex was able to suppress lung metastasis in vivo. These findings indicated that сomplexation of natural alkaloid Ber with C60 can be used as an additional therapeutic strategy against aggressive lung cancer.

Magneto-reactance based detection of MnO nanoparticle-embedded Lewis lung carcinoma cells

2015 ◽  
Vol 117 (17) ◽  
pp. 17D123 ◽  
Author(s):  
J. Devkota ◽  
M. Howell ◽  
P. Mukherjee ◽  
H. Srikanth ◽  
S. Mohapatra ◽  
...  
Keyword(s):  
Lung Carcinoma ◽  
Lewis Lung Carcinoma ◽  
Carcinoma Cells ◽  
Lewis Lung ◽  
Lung Carcinoma Cells ◽  
Lewis Lung Carcinoma Cells

Phyllanthus urinaria triggers the apoptosis and Bcl-2 down-regulation in Lewis lung carcinoma cells

Life Sciences ◽  
2003 ◽  
Vol 72 (15) ◽  
pp. 1705-1716 ◽  
Author(s):  
Sheng-Teng Huang ◽  
Rong-Chi Yang ◽  
Li-Jiun Yang ◽  
Pei-Nir Lee ◽  
Jong-Hwei S. Pang
Keyword(s):  
Lung Carcinoma ◽  
Lewis Lung Carcinoma ◽  
Carcinoma Cells ◽  
Lewis Lung ◽  
Down Regulation ◽  
Lung Carcinoma Cells ◽  
Phyllanthus Urinaria ◽  
Lewis Lung Carcinoma Cells
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