scholarly journals A Turn-ON fluorometric biosensor based on ssDNA immobilized with a metal phenolic nanomaterial for the sequential detection of Pb(ii) and epirubicin cancer drug

RSC Advances ◽  
2021 ◽  
Vol 11 (20) ◽  
pp. 12361-12373
Author(s):  
A. Arunjegan ◽  
P. Rajaji ◽  
S. Sivanesan ◽  
P. Panneerselvam
Keyword(s):  
Acridine Orange ◽  
Cancer Drug ◽  
Sequential Detection ◽  
Label Free ◽  
Fluorescent Biosensor ◽  
Turn On

In this paper, we propose a fluorescent biosensor for the sequential detection of Pb2+ ions and the cancer drug epirubicin (Epn) using the interactions between label-free guanine-rich ssDNA (LFGr-ssDNA), acridine orange (AO), and a metal–phenolic nanomaterial.

Ultrasensitive and turn-on homogeneous Hg2+ sensing based on target-triggered isothermal cycling reaction and dsDNA-templated copper nanoparticles

2021 ◽  
Author(s):  
Qingli Chai ◽  
Yuqi Wan ◽  
Yanyun Zou ◽  
Ting Zhu ◽  
Ningxing Li ◽  
...  
Keyword(s):  
Copper Nanoparticles ◽  
Label Free ◽  
Turn On ◽  
Signal Output

In this work, an ultrasensitive and turn-on sensor for homogeneous Hg2+ detection has been constructed based on target-triggered isothermal cycling reaction and rapid label-free signal output with dsDNA-templated copper nanoparticles...

Multimode binding and stimuli responsive displacement of acridine orange dye complexed with p-sulfonatocalix[4/6]arene macrocycles

2020 ◽  
Vol 22 (23) ◽  
pp. 13306-13319
Author(s):  
Mhejabeen Sayed ◽  
Dona M. Tom ◽  
Haridas Pal
Keyword(s):  
Acridine Orange ◽  
Dynamic Quenching ◽  
Stimuli Responsive ◽  
Turn On ◽  
Pictorial Presentation ◽  
Fluorescence Turn On ◽  
Multi Mode

Pictorial presentation of the different aspects as displayed by the AOH+–SCXn systems in regard to multi-mode binding, dynamic quenching and stimuli responsive fluorescence “turn ON”, demonstrating very rich supramolecular photochemistry.

Silver nanocluster-lightened hybridization chain reaction

RSC Advances ◽  
2016 ◽  
Vol 6 (62) ◽  
pp. 57502-57506 ◽  
Author(s):  
Lin Liu ◽  
Qing Li ◽  
Li-Juan Tang ◽  
Ru-Qin Yu ◽  
Jian-Hui Jiang
Keyword(s):  
Nucleic Acid ◽  
Silver Nanoclusters ◽  
Hybridization Chain Reaction ◽  
Label Free ◽  
Chain Reaction ◽  
Silver Nanocluster ◽  
Turn On ◽  
Nucleic Acid Assays

A hybridization chain reaction (HCR) lightened by DNA-stabilized silver nanoclusters (AgNCs) as a label-free and turn on fluorescence platform for nucleic acid assays.

A Highly Sensitive and Label-Free Microbead-Based ‘Turn-On’ Colorimetric Sensor for the Detection of Mercury(II) in Urine Using a Peroxidase-Like Split G-Quadruplex–Hemin DNAzyme

2018 ◽  
Vol 71 (12) ◽  
pp. 945
Author(s):  
Xin Fu ◽  
He Zhang ◽  
Jie Zhang ◽  
Shi-Tong Wen ◽  
Xing-Cheng Deng
Keyword(s):  
Standard Deviation ◽  
Base Pair ◽  
Limit Of Detection ◽  
Label Free ◽  
Turn On ◽  
Highly Sensitive ◽  
Relative Standard ◽  
G Quadruplex ◽  
Catalytically Active ◽  
Partial Cdna

A highly sensitive and label-free microbead-based ‘turn-on’ assay was developed for the detection of Hg2+ in urine based on the Hg2+-mediated formation of intermolecular split G-quadruplex–hemin DNAzymes. In the presence of Hg2+, T–T mismatches between the two partial cDNA strands were stabilized by a T–Hg2+–T base pair, and can cause the G-rich sequences of the two oligonucleotides to associate to form a split G-quadruplex which is able to bind hemin to form the catalytically active G-quadruplex–hemin DNAzyme. This microbead-based ‘turn-on’ process allows the detection of Hg2+ in urine samples at concentrations as low as 0.5 pM. The relative standard deviation and recovery are 1.2–3.9 and 98.7–103.2%, respectively. The remarkable sensitivity for Hg2+ is mainly attributed to the enhanced mass transport ability that is inherent in homogeneous microbead-based assays. Compared with previous developments of intermolecular split G-quardruplex–hemin DNAzymes for the homogeneous detection of Hg2+ (the limit of detection was 19nM), a signal enhancement of ~1000 times is obtained when such an assay is performed on the surface of microbeads.

A label-free “turn-on” fluorescence platform for glucose based on AuNCs@MnO2 nanocomposites

2019 ◽  
Vol 43 (33) ◽  
pp. 13143-13151 ◽  
Author(s):  
Shimeng Liu ◽  
Changyin Lv ◽  
Ran Liu ◽  
Guiying Yang ◽  
Shiya Li ◽  
...  
Keyword(s):  
Human Serum ◽  
Fluorescent Sensor ◽  
Sensitive Detection ◽  
Label Free ◽  
Turn On

The principle of sensitive detection of glucose in human serum using Bro-AuNCs @MnO2 nanocomposites as a fluorescent sensor.

A label-free aptasensor for turn-on fluorescent detection of ochratoxin A based on aggregation-induced emission probe

2019 ◽  
Vol 8 (1) ◽  
pp. 015003 ◽  
Author(s):  
Lei Lv ◽  
Chengbi Cui ◽  
Wancui Xie ◽  
Wenyi Sun ◽  
Shuang Ji ◽  
...  
Keyword(s):  
Ochratoxin A ◽  
Fluorescent Detection ◽  
Label Free ◽  
Aggregation Induced Emission ◽  
Turn On
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