scholarly journals Synthesis of 2-methoxybenzamide derivatives and evaluation of their hedgehog signaling pathway inhibition

RSC Advances ◽  
2021 ◽  
Vol 11 (37) ◽  
pp. 22820-22825
Author(s):  
Chiyu Sun ◽  
Dajun Zhang ◽  
Tian Luan ◽  
Youbing Wang ◽  
Wenhu Zhang ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Signaling Pathway ◽  
Hedgehog Signaling ◽  
Hedgehog Signaling Pathway ◽  
Daoy Cell ◽  
Pathway Inhibition

Benzamide analog (21) was identified as a potent hedgehog signaling pathway inhibitor that targeted the Smo receptor and blocked Daoy cell proliferation.

scholarly journals Itraconazole inhibits the Hedgehog signaling pathway thereby inducing autophagy-mediated apoptosis of colon cancer cells

2020 ◽  
Vol 11 (7) ◽  
Author(s):  
Huiming Deng ◽  
Ling Huang ◽  
Zhongkai Liao ◽  
Mi Liu ◽  
Qiang Li ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Colon Cancer ◽  
Cell Proliferation ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Hedgehog Signaling ◽  
Colon Cancer Cell ◽  
Hedgehog Signaling Pathway ◽  
Colon Cancer Cells ◽  
Hct 116

AbstractItraconazole is as an antifungal medication used to treat systemic fungal infections. Recently, it has been reported to be effective in suppressing tumor growth by inhibiting the Hedgehog signaling pathway and angiogenesis. In the present study, we investigated whether itraconazole induces autophagy-mediated cell death of colon cancer cells through the Hedgehog signaling pathway. Cell apoptosis and cell cycle distribution of the colon cancer cell lines SW-480 and HCT-116 were detected by flow cytometry and terminal TUNEL assay. Autophagy and signal proteins were detected by western blotting and cell proliferation-associated antigen Ki-67 was measured using immunohistochemistry. The images of autophagy flux and formation of autophagosomes were observed by laser scanning confocal and/or transmission electron microscopy. Colon cancer cell xenograft mouse models were also established. Itraconazole treatment inhibited cell proliferation via G1 cell cycle arrest as well as autophagy-mediated apoptosis of SW-480 and HCT-116 colon cancer cells. In addition, the Hedgehog pathway was found to be involved in activation of itraconazole-mediated autophagy. After using the Hedgehog agonist recombinant human Sonic Hedgehog (rhshh), itraconazole could counteract the activation of rhshh. Moreover, treatment with itraconazole produced significant cancer inhibition in HCT-116-bearing mice. Thus, itraconazole may be a potential and effective therapy for the treatment of colon cancer.

scholarly journals The Utility of Hedgehog Signaling Pathway Inhibition for Cancer

2012 ◽  
Vol 17 (8) ◽  
pp. 1090-1099 ◽  
Author(s):  
Solmaz Sahebjam ◽  
Lillian L. Siu ◽  
Albiruni A. Razak
Keyword(s):  
Signaling Pathway ◽  
Hedgehog Signaling ◽  
Hedgehog Signaling Pathway ◽  
Pathway Inhibition

scholarly journals 4-(Pyrimidin-2-ylamino)benzamide Derivatives：Design, Synthesis, and Hedgehog Signaling Pathway Inhibition Study

2014 ◽  
Vol 34 (7) ◽  
pp. 1407 ◽  
Author(s):  
Liandi Zhang ◽  
Minhang Xin ◽  
Jun Wen ◽  
Feng Tang ◽  
Chongxing Tu ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Hedgehog Signaling ◽  
Hedgehog Signaling Pathway ◽  
Inhibition Study ◽  
Pathway Inhibition

scholarly journals Evaluation of canonical Hedgehog signaling pathway inhibition in canine osteosarcoma

PLoS ONE ◽  
2020 ◽  
Vol 15 (4) ◽  
pp. e0231762
Author(s):  
Vincent E. Baldanza ◽  
Anita Rogic ◽  
Weiwei Yan ◽  
Corri B. Levine ◽  
Roy A. Levine ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Hedgehog Signaling ◽  
Hedgehog Signaling Pathway ◽  
Canine Osteosarcoma ◽  
Pathway Inhibition

scholarly journals Paradoxical prosteatotic effect of hedgehog signaling pathway inhibition under conditions of steatosis

Hepatology ◽  
2012 ◽  
Vol 56 (4) ◽  
pp. 1587-1588 ◽  
Author(s):  
Manuele Gori ◽  
Barbara Barbaro ◽  
Mario Arciello ◽  
Clara Balsano
Keyword(s):  
Signaling Pathway ◽  
Hedgehog Signaling ◽  
Hedgehog Signaling Pathway ◽  
Pathway Inhibition
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