Customized Self-assembled Molecules: Rim Adjustable Coronal Polygons with Multiple-Folds Symmetry

2021 ◽  
Author(s):  
Mingzhao Chen ◽  
Jia-nan Cao ◽  
Suqing Li ◽  
Die Liu ◽  
Jun Wang ◽  
...  
Keyword(s):  
Potential Applications ◽  
Self Assembled

The manufacturing of special architectures with predefined and predictable shape has received much attention on account of their potential applications. Understanding the mechanistic principles of the designed ligand is crucial...

Self-Assembled Fluid Phase Floating Membranes with Tuneable Water Interlayers

2019 ◽  
Author(s):  
Luke Clifton ◽  
Nicoló Paracini ◽  
Arwel V. Hughes ◽  
Jeremy H. Lakey ◽  
Nina-Juliane Seinke ◽  
...  
Keyword(s):  
Fluid Phase ◽  
Interlayer Thickness ◽  
Supported Bilayers ◽  
Self Assembled Monolayer ◽  
High Coverage ◽  
Nano Technology ◽  
Surface Distance ◽  
Potential Applications ◽  
Self Assembled ◽  
Coated Surfaces

<p>We present a reliable method for the fabrication of fluid phase unsaturated bilayers which are readily self-assembled on charged self-assembled monolayer (SAM) surfaces producing high coverage floating supported bilayers where the membrane to surface distance could be controlled with nanometer precision. Vesicle fusion was used to deposit the bilayers onto anionic SAM coated surfaces. Upon assembly the bilayer to SAM solution interlayer thickness was 7-10 Å with evidence suggesting that this layer was present due to SAM hydration repulsion of the bilayer from the surface. This distance could be increased using low concentrations of salts which caused the interlayer thickness to enlarge to ~33 Å. Reducing the salt concentration resulted in a return to a shorter bilayer to surface distance. These accessible and controllable membrane models are well suited to a range of potential applications in biophysical studies, bio-sensors and Nano-technology.</p><br>

scholarly journals Chirality in porous self-assembled monolayer networks at liquid/solid interfaces: induction, reversion, recognition and transfer

2021 ◽  
Author(s):  
Yoshito Tobe ◽  
Kazukuni Tahara ◽  
Steven De Feyter
Keyword(s):  
Two Dimensions ◽  
Self Assembled Monolayer ◽  
Supramolecular Chirality ◽  
Potential Applications ◽  
Self Assembled ◽  
Chirality Control

Chirality in two-dimensions (2D) has attracted increasing attention with regard to interesting fundamental aspects as well as potential applications. This article reports several aspects of supramolecular chirality control as exemplified...

Development of Multilayered Chlorogenate-Peptide Based Biocomposite Scaffolds for Potential Applications in Ligament Tissue Engineering - An In Vitro Study

2017 ◽  
Vol 34 ◽  
pp. 37-56 ◽  
Author(s):  
Harrison T. Pajovich ◽  
Alexandra M. Brown ◽  
Andrew M. Smith ◽  
Sara K. Hurley ◽  
Jessica R. Dorilio ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Type I Collagen ◽  
Phase Changes ◽  
Peptide Sequence ◽  
Proteoglycan Synthesis ◽  
Type I ◽  
Average Roughness ◽  
Potential Applications ◽  
Self Assembled

In this work, for the first time, chlorogenic acid, a natural phytochemical, was conjugated to a lactoferrin derived antimicrobial peptide sequence RRWQWRMKKLG to develop a self-assembled template. To mimic the components of extracellular matrix, we then incorporated Type I Collagen, followed by a sequence of aggrecan peptide (ATEGQVRVNSIYQDKVSL) onto the self-assembled templates for potential applications in ligament tissue regeneration. Mechanical properties and surface roughness were studied and the scaffolds displayed a Young’s Modulus of 169 MP and an average roughness of 72 nm respectively. Thermal phase changes were studied by DSC analysis. Results showed short endothermic peaks due to water loss and an exothermic peak due to crystallization of the scaffold caused by rearrangement of the components. Biodegradability studies indicated a percent weight loss of 27.5 % over a period of 37 days. Furthermore, the scaffolds were found to adhere to fibroblasts, the main cellular component of ligament tissue. The scaffolds promoted cell proliferation and displayed actin stress fibers indicative of cell motility and attachment. Collagen and proteoglycan synthesis were also promoted, demonstrating increased expression and deposition of collagen and proteoglycans. Additionally, the scaffolds exhibited antimicrobial activity against Staphylococcus epidermis bacteria, which is beneficial for minimizing biofilm formation if potentially used as implants. Thus, we have developed a novel biocomposite that may open new avenues to enhance ligament tissue regeneration.

scholarly journals A Simple Self-Adjuvanting Biomimetic Nanovaccine Self-Assembled with the Conjugate of Phospholipids and Nucleotides Can Induce Strong Cancer Immunotherapeutic Effect

2020 ◽  
Author(s):  
Dan Liu ◽  
Jiale Liu ◽  
Bing Ma ◽  
Bo Deng ◽  
Haiyan Xu ◽  
...  
Keyword(s):  
Suppressive Effect ◽  
Cpg Odn ◽  
Mhc I ◽  
Cross Presentation ◽  
Biomimetic Nanoparticles ◽  
Potential Applications ◽  
Survival Prolongation ◽  
Self Assembled ◽  
Cancer Immunotherapeutic ◽  
Cellular Immune

Abstract Background: Biomimetic nanoparticles have potential applications in many fields for their favorable properties. Results: Here, we developed a self-adjuvanting biomimetic anti-tumor nanovaccine, which was self-assembled with an amphiphilic conjugate synthetized with phospholipids of 1, 2-Dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) and hydrophilic Toll-like receptor (TLR9) agonists CpG ODN. The nanovaccine could not only provide effective initial antigens stimulation and sustained long-term antigen supply with a controlled release, but also induce antigens cross-presentation via MHC-I pathway initiating CD8+ T-cell responses. Moreover, the dense nucleotides shell around the nanovaccine could promote antigens endocytosis via various receptor-mediated pathways into dendritic cells. And CpG ODN interacted with TLR9 triggering the cytokines secretion of TNF-α and IL-10 further boosted the anti-tumor humoral and cellular immune responses, which led to significant tumor suppressive effect and remarkable survival prolongation. Conclusions: So, this nanovaccine self-assembled with phospholipid-nucleotide amphiphiles can serve as a safe, simple and efficient approach for anti-tumor immunotherapy.

scholarly journals Monitoring of Enzymatic Proteolysis Using Self-Assembled Quantum Dot-Protein Substrate Sensors

2008 ◽  
Vol 2008 ◽  
pp. 1-10 ◽  
Author(s):  
Aaron R. Clapp ◽  
Ellen R. Goldman ◽  
H. Tetsuo Uyeda ◽  
Eddie L. Chang ◽  
Jessica L. Whitley ◽  
...  
Keyword(s):  
Quantum Dot ◽  
Proteolytic Enzymes ◽  
Resonance Energy Transfer ◽  
Resonance Energy ◽  
Enzymatic Digestion ◽  
Enzymatic Proteolysis ◽  
Potential Applications ◽  
Multiple Copies ◽  
Self Assembled

We have previously utilized hybrid semiconductor quantum dot- (QD-) peptide substrates for monitoring of enzymatic proteolysis. In this report, we expand on this sensing strategy to further monitor protein-protease interactions. We utilize QDs self-assembled with multiple copies of dye-labeled proteins as substrates for the sensing of protease activity. Detection of proteolysis is based on changes in the rate of fluorescence resonance energy transfer (FRET) between the QDs and the proximal dye-labeled proteins following protein digestion by added enzyme. Our study focused on two representative proteolytic enzymes: the cysteine protease papain and the serine protease endoproteinase K. Analysis of the enzymatic digestion allowed us to estimate minimal values for the enzymatic activities of each enzyme used. Mechanisms of enzymatic inhibition were also inferred from the FRET data collected in the presence of inhibitors. Potential applications of this technology include drug discovery assays and in vivo cellular monitoring of enzymatic activity.

scholarly journals Self-assembled nanocapsules in water: a molecular mechanistic study

2017 ◽  
Vol 19 (31) ◽  
pp. 20377-20382
Author(s):  
Hang Xiao ◽  
Xiaoyang Shi ◽  
Xi Chen
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Internal Pressure ◽  
Mechanistic Study ◽  
Potential Applications ◽  
Self Assembled ◽  
High Internal Pressure ◽  
Very High

One-end-open carbon nanotubes with an appropriate radius difference can coaxially self-assemble into a nanocapsule with very high internal pressure (on the order of 1 GPa), underpinning potential applications in nano-reactors, drug-delivery, etc.

Nonlinear Optical Microscopy for Imaging Patterned Self-Assembled Monolayers

1996 ◽  
Vol 440 ◽  
Author(s):  
L. Smilowitz ◽  
Q.X. Jia ◽  
X. Yang ◽  
D.Q. Li ◽  
D. McBranch ◽  
...  
Keyword(s):  
Nonlinear Optical ◽  
Second Harmonic ◽  
Self Assembled Monolayers ◽  
Optical Technique ◽  
Nonlinear Optical Microscopy ◽  
Surface Sensitivity ◽  
Surfaces And Interfaces ◽  
Assembled Monolayers ◽  
Potential Applications ◽  
Self Assembled

AbstractWe have used the inherent surface sensitivity of second harmonic generation (SHG) to develop an instrument for nonlinear optical (NLO) microscopy of surfaces and interfaces. This optical technique is ideal for imaging nanometer thick self-assembled monolayers (SAM's) which have been patterned using photolithographic techniques. In this paper we demonstrate the application of SHG microscopy to patterned SAM's of the noncentrosymmetric molecule calixarene and discuss other potential applications for this new technique.

scholarly journals Self-assembled functional components-doped conductive polypyrrole composite hydrogels with enhanced electrochemical performances

RSC Advances ◽  
2020 ◽  
Vol 10 (18) ◽  
pp. 10546-10551 ◽  
Author(s):  
Juanjuan Yin ◽  
Qingqing Liu ◽  
Jingxin Zhou ◽  
Lexin Zhang ◽  
Qingrui Zhang ◽  
...  
Keyword(s):  
Electrochemical Performances ◽  
Composite Hydrogels ◽  
Potential Applications ◽  
Self Assembled ◽  
Polypyrrole Composite ◽  
Functional Components ◽  
Conductive Polypyrrole

New functional components-doped conductive polypyrrole composite hydrogels are prepared via a self-assembled process, demonstrating potential applications in catalysis as well as electrochemical materials.

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