Recent Advances on Catalytic Enantioselective Direct C-H Bond Functionalization of Electron-Deficient N-Containing Heteroarenes

2021 ◽  
Author(s):  
Xiao-Lan Liu ◽  
Luo-Bin Jiang ◽  
Mupeng Luo ◽  
Zhi Ren ◽  
Shou-Guo Wang
Keyword(s):  
Catalytic Systems ◽  
Bond Functionalization ◽  
Recent Advances

Catalytic enantioselective direct C-H bond functionalization of electron-deficient N-containing heteroarenes represents one of the most straightforward and powerful protocols to construct diverse enantioenriched highly functionalized N-heteroarene products. Efficient catalytic systems...

Recent Advances in the Incorporation of CO2 for C-H and C-C bond Functionalization

2021 ◽  
Author(s):  
Sandeep Pimparkar ◽  
Aishwarya K. Dalvi ◽  
Adithyaraj Koodan ◽  
Siddhartha Maiti ◽  
Shaeel Al-Thabaiti ◽  
...  
Keyword(s):  
Organic Chemistry ◽  
Carbon Dioxide ◽  
Thermodynamic Stability ◽  
Cost Effective ◽  
Bond Functionalization ◽  
Synthetic Organic Chemistry ◽  
Recent Advances ◽  
Carbon Dioxide Co2

Carbon dioxide (CO2) has emerged as one of the exciting cost-effective, abundant, and ready-to-use C1 sources in synthetic organic chemistry. However, the thermodynamic stability, as well as the kinetic inertness,...

scholarly journals Recent Advances in Heterogeneous Catalytic Systems Containing Metal Ions for Phosphate Ester Hydrolysis

2020 ◽  
Author(s):  
Marco Antônio G. B. Gomes ◽  
Christiane Fernandes ◽  
Lawrence R. Gahan ◽  
Gerhard Schenk ◽  
Adolfo Horn
Keyword(s):  
Metal Ions ◽  
Ester Hydrolysis ◽  
Phosphate Ester ◽  
Catalytic Systems ◽  
Phosphate Ester Hydrolysis ◽  
Heterogeneous Catalytic ◽  
Recent Advances

scholarly journals Copper-catalyzed enantioselective conjugate addition of organometallic reagents to challenging Michael acceptors

2020 ◽  
Vol 16 ◽  
pp. 212-232 ◽  
Author(s):  
Delphine Pichon ◽  
Jennifer Morvan ◽  
Christophe Crévisy ◽  
Marc Mauduit
Keyword(s):  
Natural Products ◽  
Conjugate Addition ◽  
Catalytic Transformation ◽  
Chiral Molecules ◽  
Catalytic Systems ◽  
Organometallic Reagents ◽  
Recent Advances ◽  
Wide Range ◽  
Michael Acceptors

The copper-catalyzed enantioselective conjugate addition (ECA) of organometallic nucleophiles to electron-deficient alkenes (Michael acceptors) represents an efficient and attractive methodology for providing a wide range of relevant chiral molecules. In order to increase the attractiveness of this useful catalytic transformation, some Michael acceptors bearing challenging electron-deficient functions (i.e., aldehydes, thioesters, acylimidazoles, N-acyloxazolidinones, N-acylpyrrolidinones, amides, N-acylpyrroles) were recently investigated. Remarkably, only a few chiral copper-based catalytic systems have successfully achieved the conjugate addition of different organometallic reagents to these challenging Michael acceptors, with excellent regio- and enantioselectivity. Furthermore, thanks to their easy derivatization, the resulting chiral conjugated products could be converted into various natural products. The aim of this tutorial review is to summarize recent advances accomplished in this stimulating field.

scholarly journals Recent Advances on the C-H Bond Functionalization on C(5) Position of 8-Aminoquinolines

2017 ◽  
Vol 37 (7) ◽  
pp. 1613 ◽  
Author(s):  
Longzhi Zhu ◽  
Xin Cao ◽  
You Li ◽  
Ting Liu ◽  
Xie Wang ◽  
...  
Keyword(s):  
Bond Functionalization ◽  
Recent Advances

scholarly journals Recent Developments in Transition-Metal Catalyzed Direct C–H Alkenylation, Alkylation, and Alkynylation of Azoles

Molecules ◽  
2020 ◽  
Vol 25 (21) ◽  
pp. 4970
Author(s):  
Su Chen ◽  
Prabhat Ranjan ◽  
Leonid G. Voskressensky ◽  
Erik V. Van der Eycken ◽  
Upendra K. Sharma
Keyword(s):  
Transition Metal ◽  
Transition Metal Catalysis ◽  
Significant Progress ◽  
Metal Catalysis ◽  
Bond Functionalization ◽  
Recent Advances ◽  
Regioselective Alkylation ◽  
Recent Developments ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

The transition metal-catalyzed C–H bond functionalization of azoles has emerged as one of the most important strategies to decorate these biologically important scaffolds. Despite significant progress in the C–H functionalization of various heteroarenes, the regioselective alkylation and alkenylation of azoles are still arduous transformations in many cases. This review covers recent advances in the direct C–H alkenylation, alkylation and alkynylation of azoles utilizing transition metal-catalysis. Moreover, the limitations of different strategies, chemoselectivity and regioselectivity issues will be discussed in this review.

scholarly journals Recent Advances in Catalytic Synthesis of Benzosultams

Molecules ◽  
2020 ◽  
Vol 25 (19) ◽  
pp. 4367
Author(s):  
Quan-Qing Zhao ◽  
Xiao-Qiang Hu
Keyword(s):  
Medicinal Chemistry ◽  
Catalytic Synthesis ◽  
Chiral Catalysts ◽  
Catalytic Systems ◽  
The Past ◽  
Recent Advances ◽  
Efficient Construction

Benzosultams represent one category of multi-heteroatom heterocyclic scaffolds, which have been frequently found in pharmaceuticals, agricultural agents, and chiral catalysts. Given the diversely significant functions of these compounds in organic and medicinal chemistry, great efforts have been made to develop novel catalytic systems for the efficient construction of benzosultam motifs over the past decades. Herein, in this review, we mainly summarize the recent advances in the field of catalytic synthesis of benzosultams from 2017 to August of 2020, with an emphasis on the scopes and mechanisms of representative reactions.

Mechanistic view of Ru-catalyzed C–H bond activation and functionalization: computational advances

2018 ◽  
Vol 47 (20) ◽  
pp. 7552-7576 ◽  
Author(s):  
Chunhui Shan ◽  
Lei Zhu ◽  
Ling-Bo Qu ◽  
Ruopeng Bai ◽  
Yu Lan
Keyword(s):  
Bond Activation ◽  
Theoretical Perspective ◽  
Mechanistic Study ◽  
Bond Functionalization ◽  
Recent Advances ◽  
Mechanistic View

This review summarized recent advances in the mechanistic study of Ru-catalyzed C–H bond functionalization from a theoretical perspective.

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