Rhenium carbonyl complexes bearing methylated triphenylphosphonium cations as antibody-free mitochondria trackers for X-ray fluorescence imaging

2021 ◽  
Author(s):  
Gabrielle Schanne ◽  
Lucas Henry ◽  
How Chee Ong ◽  
andrea somogyi ◽  
Kadda Medjoubi ◽  
...  
Keyword(s):  
Synchrotron Radiation ◽  
Metal Complexes ◽  
Fluorescence Imaging ◽  
Biological Systems ◽  
Carbonyl Complexes ◽  
X Ray ◽  
Powerful Technique ◽  
Rhenium Carbonyl

Synchrotron Radiation X-ray Fluorescence (SXRF) imaging is a powerful technique for the visualization of metal complexes in biological systems. However, due to the lack of an endogenous elemental signature for...

scholarly journals Rhenium Carbonyl Complexes Conjugated with Methylated Triphenylphosphonium Cations as Sensitive Mitochondria Trackers for X-Ray Fluorescence Imaging

2021 ◽  
Author(s):  
Gabrielle Schanne ◽  
Lucas Henry ◽  
How Chee Ong ◽  
Andrea Somogyi ◽  
Kadda Medjoubi ◽  
...  
Keyword(s):  
Synchrotron Radiation ◽  
Metal Complexes ◽  
Fluorescence Imaging ◽  
Biological Systems ◽  
A549 Cells ◽  
Carbonyl Complexes ◽  
X Ray ◽  
Powerful Technique ◽  
Rhenium Carbonyl ◽  
Nano Imaging

<div>Synchrotron Radiation X-ray Fluorescence (SXRF) imaging is a powerful technique for the visualization of metal complexes in biological systems. However, due to the lack of an endogenous elemental signature for mitochondria, probes for the localization of this organelle are required for colocalization studies. In this work, we designed and synthesized rhenium pyta tricarbonyl complexes conjugated to methylated triphenylphosphonium TP*P+ cations as multimodal probes for the visualization of mitochondria, suitable for fluorescence and SXRF imaging and quantification. Accumulation of the methylated triphenylphosphonium TP*P+-based conjugates in cells was observed in fixed A549 cells, and the amount of mitochondrial uptake was linked to the lipophilicity of the TPP+ vector. Our work highlights a convenient rhenium-based multimodal mitochondrial-targeted probe compatible with SXRF nano-imaging.</div>

scholarly journals Rhenium Carbonyl Complexes Conjugated with Methylated Triphenylphosphonium Cations as Sensitive Mitochondria Trackers for X-Ray Fluorescence Imaging

2021 ◽  
Author(s):  
Gabrielle Schanne ◽  
Lucas Henry ◽  
How Chee Ong ◽  
Andrea Somogyi ◽  
Kadda Medjoubi ◽  
...  
Keyword(s):  
Synchrotron Radiation ◽  
Metal Complexes ◽  
Fluorescence Imaging ◽  
Biological Systems ◽  
A549 Cells ◽  
Carbonyl Complexes ◽  
X Ray ◽  
Powerful Technique ◽  
Rhenium Carbonyl ◽  
Nano Imaging

<div>Synchrotron Radiation X-ray Fluorescence (SXRF) imaging is a powerful technique for the visualization of metal complexes in biological systems. However, due to the lack of an endogenous elemental signature for mitochondria, probes for the localization of this organelle are required for colocalization studies. In this work, we designed and synthesized rhenium pyta tricarbonyl complexes conjugated to methylated triphenylphosphonium TP*P+ cations as multimodal probes for the visualization of mitochondria, suitable for fluorescence and SXRF imaging and quantification. Accumulation of the methylated triphenylphosphonium TP*P+-based conjugates in cells was observed in fixed A549 cells, and the amount of mitochondrial uptake was linked to the lipophilicity of the TPP+ vector. Our work highlights a convenient rhenium-based multimodal mitochondrial-targeted probe compatible with SXRF nano-imaging.</div>

Mercury dynamics in hair of rats exposed to methylmercury by synchrotron radiation X-ray fluorescence imaging

Life Sciences ◽  
1997 ◽  
Vol 60 (23) ◽  
pp. 2129-2137 ◽  
Author(s):  
Nobuhiro Shimojo ◽  
Shino Homma-Takeda ◽  
Kyoko Ohuchi ◽  
Masaru Shinyashiki ◽  
Gui Fan Sun ◽  
...  
Keyword(s):  
Synchrotron Radiation ◽  
Fluorescence Imaging ◽  
X Ray

Technetium and rhenium carbonyl complexes with 1,4-benzodiazepine derivatives: X-ray crystal structure

1998 ◽  
Vol 272 (1-2) ◽  
pp. 267-273 ◽  
Author(s):  
Andrea Marchi ◽  
Lorenza Marvelli ◽  
Roberto Rossi ◽  
Valerio Bertolasi ◽  
Valeria Ferretti
Keyword(s):  
Crystal Structure ◽  
Carbonyl Complexes ◽  
X Ray ◽  
Rhenium Carbonyl ◽  
Benzodiazepine Derivatives

Waterborne versus Dietary Zinc Accumulation and Toxicity in Daphnia magna: a Synchrotron Radiation Based X-ray Fluorescence Imaging Approach

2011 ◽  
Vol 46 (2) ◽  
pp. 1178-1184 ◽  
Author(s):  
R. Evens ◽  
K. A. C. De Schamphelaere ◽  
B. De Samber ◽  
G. Silversmit ◽  
T. Schoonjans ◽  
...  
Keyword(s):  
Synchrotron Radiation ◽  
Fluorescence Imaging ◽  
Daphnia Magna ◽  
Dietary Zinc ◽  
Zinc Accumulation ◽  
X Ray ◽  
Imaging Approach
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