Facile Synthesis of Polypeptoid Bearing Bulky Sidechains via Urea Accelerated Ring-Opening Polymerization of α-Amino Acid N-Substituted N-Carboxyanhydrides

2021 ◽  
Author(s):  
Kang Chen ◽  
Yueming Wu ◽  
Xue Wu ◽  
Min Zhou ◽  
Ruiyi Zhou ◽  
...  
Keyword(s):  
Amino Acid ◽  
Ring Opening ◽  
Ring Opening Polymerization ◽  
Biological Functions ◽  
Facile Synthesis ◽  
Proteolytic Stability

Polypeptoids, as synthetic mimics of polypeptides, exhibit a variety of biological functions and excellent proteolytic stability. Polypeptoids can be synthesized by ring-opening polymerization of α-amino acid N-substituted N-carboxyanhydrides (NNCAs), however,...

Neutral lutetium complex/polyamine mediated immortal ring-opening polymerization of rac-lactide: facile synthesis of well-defined hydroxyl-end and amide-core stereoregular star polylactide

2015 ◽  
Vol 6 (44) ◽  
pp. 7711-7716 ◽  
Author(s):  
Wei Zhao ◽  
Bo Liu ◽  
Xinli Liu ◽  
Xue Wang ◽  
Yang Wang ◽  
...  
Keyword(s):  
Ring Opening ◽  
Ring Opening Polymerization ◽  
Facile Synthesis

A facile way to obtain well-defined hydroxyl-end and amide-core stereoregular star polylactide.

scholarly journals Random Poly(Amino Acid)s Synthesized by Ring Opening Polymerization as Additives in the Biomimetic Mineralization of CaCO3

Polymers ◽  
2012 ◽  
Vol 4 (2) ◽  
pp. 1195-1210 ◽  
Author(s):  
Vladimir Dmitrovic ◽  
Gijs J.M. Habraken ◽  
Marco M.R.M. Hendrix ◽  
Wouter J.E.M. Habraken ◽  
Andreas Heise ◽  
...  
Keyword(s):  
Amino Acid ◽  
Ring Opening ◽  
Ring Opening Polymerization ◽  
Biomimetic Mineralization

Organobase 1,1,3,3-Tetramethyl Guanidine Catalyzed Rapid Ring-opening Polymerization of α-Amino Acid N-carboxyanhydrides Adaptive to Amine, Alcohol and Carboxyl Acid Initiators

2021 ◽  
Author(s):  
Kai Li ◽  
Zheng Li ◽  
Yong Shen ◽  
Xiaohui Fu ◽  
Chongyi Chen ◽  
...  
Keyword(s):  
Amino Acid ◽  
Ring Opening ◽  
Ring Opening Polymerization

The initiators for ring-opening polymerization (ROP) of α-amino acid N-carboxyanhydrides (NCA) to prepare polypeptides usually require high nucleophilicity. For the initiators with lower nucleophilicity, slow initiation and fast propagation lead...

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