Modification of Polybutadiene with Trifluoromethyl and Clickable Azide Groups in One-Shot

2021 ◽  
Author(s):  
Shengfei Wang ◽  
Sen Zhang ◽  
Chun Feng ◽  
Guolin Lu ◽  
Patrick Theato ◽  
...  
Keyword(s):  
Efficient Approach ◽  
Synthetic Routes ◽  
Enhanced Properties

Development of facile synthetic routes to endow polybutadiene (PB) with desirable and/or enhanced properties, has attracted growing attention owing to broad applications of PB. Herein, we report an efficient approach...

Cobalt catalysed controlled copolymerization: an efficient approach to bifunctional polyisoprene with enhanced properties

2021 ◽  
Author(s):  
Dirong Gong ◽  
Fuming Tang ◽  
Yuechao Xu ◽  
Zhonghan Hu ◽  
Wanwei Luo
Keyword(s):  
Molecular Weight ◽  
Efficient Approach ◽  
Enhanced Properties ◽  
Insertion Polymerization

Bifunctional polyisoprene with controlled molecular weight was obtained by coordination insertion polymerization.

scholarly journals A Survey of Synthetic Routes and Antitumor Activities for Benzo[g]quinoxaline-5,10-diones

Molecules ◽  
2020 ◽  
Vol 25 (24) ◽  
pp. 5922
Author(s):  
Alain G. Giuglio-Tonolo ◽  
Christophe Curti ◽  
Thierry Terme ◽  
Patrice Vanelle
Keyword(s):  
Biological Activities ◽  
Therapeutic Index ◽  
Heterocyclic Chemistry ◽  
Antitumor Activities ◽  
Anthracycline Antibiotics ◽  
Antitumor Properties ◽  
The Common ◽  
Synthetic Routes ◽  
Enhanced Properties ◽  
Synthetic Approaches

Anthracycline antibiotics play an important role in cancer chemotherapy. The need to improve their therapeutic index has stimulated an ongoing search for anthracycline analogs with enhanced properties. This review aims to summarize the common synthetic approaches to benzo[g]quinoxaline-5,10-diones and their uses in heterocyclic chemistry. Because of the valuable biological activities of the 1,4-diazaanthraquinone compounds, a summary of the most promising heterocyclic quinones is provided together with their antitumor properties.

Efficient approach for analysis of unsteady viscous flows in turbomachines

AIAA Journal ◽  
1998 ◽  
Vol 36 ◽  
pp. 2005-2012
Author(s):  
L. He ◽  
W. Ning
Keyword(s):  
Viscous Flows ◽  
Efficient Approach

Discovery of a Difluoroglycine Synthesis Method through Quantum Chemical Calculations

2020 ◽  
Author(s):  
Tsuyoshi Mita ◽  
Yu Harabuchi ◽  
Satoshi Maeda
Keyword(s):  
Quantum Chemical Calculations ◽  
Experimental Verification ◽  
Quantum Chemical ◽  
Synthesis Method ◽  
Target Product ◽  
Systematic Exploration ◽  
Hands On ◽  
Retrosynthetic Analysis ◽  
Synthetic Routes ◽  
Verification Process

The systematic exploration of synthetic pathways to afford a desired product through quantum chemical calculations remains a considerable challenge. In 2013, Maeda et al. introduced ‘quantum chemistry aided retrosynthetic analysis’ (QCaRA), which uses quantum chemical calculations to search systematically for decomposition paths of the target product and propose a synthesis method. However, until now, no new reactions suggested by QCaRA have been reported to lead to experimental discoveries. Using a difluoroglycine derivative as a target, this study investigated the ability of QCaRA to suggest various synthetic paths to the target without relying on previous data or the knowledge and experience of chemists. Furthermore, experimental verification of the seemingly most promising path led to the discovery of a synthesis method for the difluoroglycine derivative. The extent of the hands-on expertise of chemists required during the verification process was also evaluated. These insights are expected to advance the applicability of QCaRA to the discovery of viable experimental synthetic routes.

Discovery of a Difluoroglycine Synthesis Method through Quantum Chemical Calculations

2020 ◽  
Author(s):  
Tsuyoshi Mita ◽  
Yu Harabuchi ◽  
Satoshi Maeda
Keyword(s):  
Quantum Chemical Calculations ◽  
Experimental Verification ◽  
Quantum Chemical ◽  
Synthesis Method ◽  
Target Product ◽  
Systematic Exploration ◽  
Hands On ◽  
Retrosynthetic Analysis ◽  
Synthetic Routes ◽  
Verification Process

The systematic exploration of synthetic pathways to afford a desired product through quantum chemical calculations remains a considerable challenge. In 2013, Maeda et al. introduced ‘quantum chemistry aided retrosynthetic analysis’ (QCaRA), which uses quantum chemical calculations to search systematically for decomposition paths of the target product and propose a synthesis method. However, until now, no new reactions suggested by QCaRA have been reported to lead to experimental discoveries. Using a difluoroglycine derivative as a target, this study investigated the ability of QCaRA to suggest various synthetic paths to the target without relying on previous data or the knowledge and experience of chemists. Furthermore, experimental verification of the seemingly most promising path led to the discovery of a synthesis method for the difluoroglycine derivative. The extent of the hands-on expertise of chemists required during the verification process was also evaluated. These insights are expected to advance the applicability of QCaRA to the discovery of viable experimental synthetic routes.

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