Carbohydrate-lectin recognition of well-defined heterogeneous dendronized glycopolymers: systematic studies on heterogeneity in glycopolymer-lectin binding

2021 ◽  
Author(s):  
Xingyou Wang ◽  
Mengtong Wang ◽  
Caiyun Wang ◽  
Wei Deng ◽  
Meina Liu
Keyword(s):  
Molecular Recognition ◽  
Lectin Binding ◽  
Specific Receptor ◽  
The Past ◽  
Significant Interest ◽  
Lectin Recognition

Heterogeneous glycopolymers have received significant interest in the past few years due to their potential properties in enhancing molecular recognition abilities toward a specific receptor. However, there are limited reports...

Microstructural Evolution in Al-Ti Multilayered Film with Annealing

1999 ◽  
Vol 5 (S2) ◽  
pp. 836-837
Author(s):  
R. Mitra ◽  
W.A. Chiou ◽  
A.Madan ◽  
R. Hoffman ◽  
J.R. Weertman
Keyword(s):  
Magnetron Sputtering ◽  
Ingot Metallurgy ◽  
Multilayered Film ◽  
Multilayered Structures ◽  
Multilayered Films ◽  
Specific Strength ◽  
The Past ◽  
High Specific Strength ◽  
Significant Interest ◽  
Deposited Film

There has been a significant interest in the development of dispersion-hardened aluminum for many years for high specific strength and modulus. Such materials are usually processed by powder or ingot metallurgy routes. In this study, Al3 Ti dispersion hardened Al was obtained by annealing Al-Ti multilayers. Al-Ti multilayered films have been characterized in the past by observing the structure of the layers, as well as tensile properties and hardness. This paper reports the structure of Al-Ti multilayers and the evolution of matrix and dispersoid microstructure on annealing.The Al-Ti multilayered structures were prepared by magnetron sputtering using Al and Ti as targets and either Si (100) or NaCl as substrates. The bi-layer thickness was maintained around 16 nm with Ti constituting 12% of the total. The substrate was alternately moved below the Al and Ti targets for the purpose of deposition. The as-deposited film on the substrate and NaCl salts were annealed at 400°C for periods between 1 and 24 h in a vacuum (10−5 torr) furnace.

scholarly journals Pediatric Integrative Medicine: Vision for the Future

Children ◽  
2018 ◽  
Vol 5 (8) ◽  
pp. 111 ◽  
Author(s):  
Anna Esparham ◽  
Sanghamitra Misra ◽  
Erica Sibinga ◽  
Timothy Culbert ◽  
Kathi Kemper ◽  
...  
Keyword(s):  
Integrative Medicine ◽  
Professional Education ◽  
Chronic Conditions ◽  
Pediatric Population ◽  
Family Education ◽  
Pediatric Care ◽  
The Past ◽  
Significant Interest ◽  
Important Time ◽  
Ecologically Sustainable

Pediatric integrative medicine (PIM) is of significant interest to patients, with 12% of the general pediatric population and up to 80% of children with chronic conditions using PIM approaches. The field of PIM has evolved over the past 25 years, approaching child health with a number of guiding principles: preventive, context-centered, relationship-based, personalized, participatory, and ecologically sustainable. This manuscript reviews important time points for the field of PIM and reports on a series of meetings of PIM leaders, aimed at assessing the state of the field and planning for its future. Efforts in the first decade of the 2000s led to increased visibility in academic and professional pediatric organizations and through international listservs, designed to link those interested in and practicing PIM, all of which continue to flourish. The PIM leadership summits in recent years resulted in specific goals to advance PIM further in the following key areas: research, clinical practice, professional education, patient and family education, and advocacy and partnerships. Additionally, goals were developed for greater expansion of PIM professional education, broader support for pediatric PIM research, and an expanded role for PIM approaches in the provision of pediatric care.

Glycosylation of polyphosphazenes by thiol-yne click chemistry for lectin recognition

RSC Advances ◽  
2015 ◽  
Vol 5 (21) ◽  
pp. 15909-15915 ◽  
Author(s):  
Chen Chen ◽  
Huang Xu ◽  
Yue-Cheng Qian ◽  
Xiao-Jun Huang
Keyword(s):  
Click Chemistry ◽  
Lectin Binding ◽  
Biological Systems ◽  
Binding Interactions ◽  
Lectin Recognition

Strong carbohydrate–lectin binding interactions in biological systems can be mimicked through the synthesis of glucose containing macromolecules, particularly glycosylated polymers.

scholarly journals Sessile droplets on deformable substrates

2018 ◽  
Author(s):  
Gulraiz Ahmed ◽  
Nektaria Koursari ◽  
Anna Trybala ◽  
Victor M. Starov
Keyword(s):  
Liquid Droplet ◽  
Contact Angles ◽  
Surface Forces ◽  
Interfacial Behavior ◽  
Equilibrium Conditions ◽  
The Past ◽  
Technological Advances ◽  
Three Phase ◽  
Significant Interest ◽  
Receding Contact

Wetting of deformable substrates has gained significant interest over the past decade due to its extensive applications and uses. This interest has developed due to technological advances which are able to capture interfacial behavior taking place when a liquid droplet is placed on a deformable substrate. Researchers have developed different theories to explain processes taking place in the process of wetting of deformable/soft substrates. For the scope of this review, we will consider the fluid to be Newtonian, partially wetting, and surface forces are incorporated with the help of disjoining/conjoining pressure acting in the vicinity of the apparent, three-phase contact line. The following subjects are briefly reviewed: (i) Equilibrium of droplets on soft substrates. It is shown that properties of the disjoining/conjoining pressure isotherm and properties of the deformable substrate determine both the shape of the liquid droplet and deformation of the substrate; (ii) Equilibrium conditions of droplets on deformable substrates. It is shown that for a droplet to be at equilibrium on a deformable substrate under consideration, Jacobi’s sufficient condition is satisfied; (iii) Hysteresis of contact angle of sessile droplets on deformable substrates. It is shown that as the elasticity of the deformable substrate is increased, both advancing and receding contact angles are reduced.

A Fast Shapelet Discovery Algorithm Based on Important Data Points

2017 ◽  
Vol 14 (2) ◽  
pp. 67-80 ◽  
Author(s):  
Cun Ji ◽  
Chao Zhao ◽  
Li Pan ◽  
Shijun Liu ◽  
Chenglei Yang ◽  
...  
Keyword(s):  
Time Series ◽  
Classification Accuracy ◽  
Time Series Classification ◽  
Important Data ◽  
The Past ◽  
Significant Interest ◽  
Data Points ◽  
Discovery Time ◽  
Accuracy Rates

Time series classification (TSC) has attracted significant interest over the past decade. A shapelet is one fragment of a time series that can represent class characteristics of the time series. A classifier based on shapelets is interpretable, more accurate, and faster. However, the time it takes to find shapelets is enormous. This article will propose a fast shapelet (FS) discovery algorithm based on important data points (IDPs). First, the algorithm will identify IDPs. Next, the subsequence containing one or more IDPs will be selected as a candidate shapelet. Finally, the best shapelets will be selected. Results will show that the proposed algorithm reduces the shapelet discovery time by approximately 14.0% while maintaining the same level of classification accuracy rates.

scholarly journals Old concepts, new molecules and current approaches applied to the bacterial nucleotide signalling field

2016 ◽  
Vol 371 (1707) ◽  
pp. 20150503 ◽  
Author(s):  
Angelika Gründling ◽  
Vincent T. Lee
Keyword(s):  
Mass Spectrometry ◽  
Rapid Identification ◽  
Screening Methods ◽  
Bacterial Cells ◽  
The Novel ◽  
Specific Receptor ◽  
Receptor Proteins ◽  
The Past ◽  
Genome Wide ◽  
Cellular Pathways

Signalling nucleotides are key molecules that help bacteria to rapidly coordinate cellular pathways and adapt to changes in their environment. During the past 10 years, the nucleotide signalling field has seen much excitement, as several new signalling nucleotides have been discovered in both eukaryotic and bacterial cells. The fields have since advanced quickly, aided by the development of important tools such as the synthesis of modified nucleotides, which, combined with sensitive mass spectrometry methods, allowed for the rapid identification of specific receptor proteins along with other novel genome-wide screening methods. In this review, we describe the principle concepts of nucleotide signalling networks and summarize the recent work that led to the discovery of the novel signalling nucleotides. We also highlight current approaches applied to the research in the field as well as resources and methodological advances aiding in a rapid identification of nucleotide-specific receptor proteins. This article is part of the themed issue ‘The new bacteriology’.

Simulations on Sliding Process between Si-DLC and DLC Films on a Water-Lubricated Condition

2010 ◽  
Vol 29-32 ◽  
pp. 1408-1413 ◽  
Author(s):  
Hui Qing Lan ◽  
Can Liu ◽  
Takahisa Kato
Keyword(s):  
Sliding Friction ◽  
Md Simulations ◽  
Low Friction ◽  
Wear Performance ◽  
Friction Process ◽  
The Past ◽  
Significant Interest ◽  
Lubrication Layer ◽  
Higher Temperature ◽  
Silicon Doped

Diamond like carbon (DLC) films have been extensively studied over the past decades due to their unique combination of properties, in particular, silicon-doped DLC (Si-DLC) films are of significant interest for tribological effects, they had a very low friction coefficient and possess the potential to improve wear performance in humid atmospheres and at higher temperature. But many experimental results of the Si-DLC films showed that their tribological properties changed greatly on different silicon contents. In the paper, molecular dynamics (MD) simulations were used to study a sliding friction process between Si-DLC and DLC films on an un-lubricated and a water-lubricated condition respectively. The results have been shown that a transfer film between the Si-DLC and DLC films was formed on the un-lubricated condition. In contrast, a boundary lubrication layer was found on the water-lubricated condition. Moreover, the friction force on the un-lubricated condition was larger than those on the water-lubricated condition.

scholarly journals Recent Updates of Natural and Synthetic URAT1 Inhibitors and Novel Screening Methods

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Ying Chen ◽  
Ruya You ◽  
Ke Wang ◽  
Yousheng Wang
Keyword(s):  
Uric Acid ◽  
Side Effects ◽  
Therapeutic Target ◽  
Screening Methods ◽  
Renal Tubules ◽  
The Past ◽  
Anion Transporter ◽  
Promising Therapeutic Target ◽  
Significant Interest ◽  
Natural And Synthetic

Human urate anion transporter 1 (hURAT1) is responsible for the reabsorption of uric acid in the proximal renal tubules and is a promising therapeutic target for treating hyperuricemia. To mitigate the side effects of URAT1-targeted clinical agents such as benzbromarone, there is significant interest in discovering new URAT1 inhibitors and developing technology that can evaluate URAT1 inhibition. This review summarizes the methods for assay of URAT1 inhibition and the progress on the discovery of natural and synthetic URAT1 inhibitors in the past five years.

A Decade of Customer Engagement Research in Hospitality and Tourism: A Systematic Review and Research Agenda

2019 ◽  
Vol 44 (2) ◽  
pp. 178-200 ◽  
Author(s):  
Kevin Kam Fung So ◽  
Xiang (Robert) Li ◽  
Hyunsu Kim
Keyword(s):  
Relevant Literature ◽  
Analytical Techniques ◽  
Customer Engagement ◽  
The Past ◽  
Significant Interest ◽  
The Status ◽  
Methodological Approaches ◽  
Hospitality And Tourism ◽  
Antecedents And Consequences ◽  
Scholarly Inquiry

Over the past decade, customer engagement has attracted significant interest from academics and practitioners. This article reviews and synthesizes customer engagement research published in seven leading hospitality and tourism journals between 2009 and 2019. It systematically analyzes publication outlets and trajectories, study sectors, methodological approaches, analytical techniques, conceptualizations of customer engagement, classifications of antecedents and consequences, and key mediators and moderators. This article also presents a model summarizing extant customer engagement research and identifies critical avenues for future scholarly inquiry into customer engagement. The comprehensive review and analysis offered in this article contribute to the literature by detailing the status of customer engagement research and the evolution of relevant literature over the past 11 years.

Sustainable Smart-Farming Framework

2019 ◽  
pp. 147-173 ◽  
Author(s):  
Pankaj Agarwal ◽  
Vijander Singh ◽  
G. L. Saini ◽  
Deepak Panwar
Keyword(s):  
Environmental Change ◽  
New Technologies ◽  
Agricultural Practices ◽  
Vital Role ◽  
Significant Part ◽  
Biological Models ◽  
Economic Prosperity ◽  
The Past ◽  
Smart Farming ◽  
Significant Interest

Agriculture and allied activities play a vital role in a country's economic prosperity. The conventional methods in agricultural practices have become insufficient to cater to the increasing needs. To fulfill the demands, new technologies are to be introduced to raise agricultural standards. Over the past few years, there has been significant interest in designing smart agricultural systems. The manageability of agricultural frameworks has turned into a noteworthy concentration for discusses about future human survival. A significant part of the contention seems to depend on shortsighted understanding of biological models and flops enough to define what maintainability goals are being looked for. To adapt to the undeniably multifaceted nature and between connectedness of current cultivating frameworks with regards to globalization and potential bothers like environmental change, we require a pluralistic way to deal with strategy, which can adapt to the abnormal amounts of vulnerability in these territories and which enables most extreme flexibility of reaction to evolving conditions.

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