Tandem Aza-Michael Addition―Vinylogous Aldol Condensation: Synthesis of N-Bridged Pyridine Fused Quinolones

2022 ◽  
Author(s):  
Lalitha Gummidi ◽  
Altaf Muddassar ◽  
Gangavaram VM Sharma ◽  
Murugesh V ◽  
Surisetti Suresh
Keyword(s):  
Michael Addition ◽  
Aldol Condensation ◽  
Quinolone Derivatives

Herein, we present a tandem aza-Michael addition―vinylogous aldol condensation strategy for the synthesis of N-bridged pyridine fused quinolone derivatives from quinolones and ynones. The presented tandem transformation features the construction...

Catalyst-Free One-Pot Synthesis of Novel Heteroarylamine Substituted Furo[3,2-c]coumarins

Synlett ◽  
2018 ◽  
Vol 29 (12) ◽  
pp. 1589-1592 ◽  
Author(s):  
Abolfazl Olyaei ◽  
Mahnaz Saraei ◽  
Reyhaneh Khoeiniha
Keyword(s):  
Michael Addition ◽  
Aldol Condensation ◽  
Ring Closure ◽  
Dehydration Reaction ◽  
One Pot ◽  
Catalyst Free ◽  
One Pot Synthesis ◽  
Tandem Process ◽  
First Time

A high-yielding cyclocondensation of 4-hydroxycoumarin, phenylglyoxal monohydrate, and heteroarylamines proceeds without catalysis, which gives novel functionalized furo[3,2-c]coumarins and heteroarylamino alkylation of coumarin products in acetonitrile under reflux, is reported for the first time. This tandem process involves sequentially an aldol condensation, Michael addition, a ring closure, and dehydration reaction.

TiO2 nano crystallites catalyzed water mediated microwave assisted regioselective three component domino hydrolysis/aldol condensation/Michael addition reaction of 3-(1,5-dioxo-1,5-diphenylpentan-3-yl)quinolin-2(1H)-one

RSC Advances ◽  
2014 ◽  
Vol 4 (100) ◽  
pp. 57016-57025 ◽  
Author(s):  
Eethamukkala Ubba ◽  
Fazlur-Rahman Nawaz Khan ◽  
Euh Duck Jeong ◽  
Eun Hyuk Chung
Keyword(s):  
Michael Addition ◽  
Addition Reaction ◽  
Aldol Condensation ◽  
Michael Addition Reaction ◽  
Microwave Assisted ◽  
Nano Crystalline

Microwave supported, water intervened, nano crystalline TiO2 catalyzed synthesis of 3-(1,5-dioxo-1,5-diphenylpentan-3-yl)quinolin-2(1H)-ones, is described.

Michael addition and aldol condensation: A simple teaching model for organic laboratory

1986 ◽  
Vol 63 (5) ◽  
pp. 443 ◽  
Author(s):  
A. Garcia-Raso ◽  
J. Garcia-Raso ◽  
J. V. Sinisterra ◽  
R. Mestres
Keyword(s):  
Michael Addition ◽  
Aldol Condensation ◽  
Teaching Model ◽  
Organic Laboratory

scholarly journals Synthesis of Coumarins and Quinolones by Intramolecular Aldol Condensation Reactions of Titanium Enediolates

1995 ◽  
Vol 50 (3) ◽  
pp. 326-332 ◽  
Author(s):  
Alois Fürstner ◽  
Denis N. Jumbam ◽  
Nongyuan Shi
Keyword(s):  
Organic Synthesis ◽  
Zinc Dust ◽  
Aldol Condensation ◽  
Condensation Reactions ◽  
Low Valent ◽  
Aldol Condensation Reactions ◽  
Quinolone Derivatives

Low-valent titanium prepared by the reduction of TiCl3 with zinc dust oxidatively adds to α-ketoamides or α-ketoesters with the formation of the corresponding titanium enediolates. These 1,2-difunctional nucleophiles, which have hardly been used in organic synthesis so far, undergo regioselective intramolecular aldol condensation reactions with various electrophiles such as aldehydes, ketones, nitriles, esters and amides. This methodology allows the synthesis of differently substituted coumarin and 2-quinolone derivatives.

Steroids. LXIX.1,2a,bA Novel Michael Addition-Aldol Condensation Reaction between Acetone and Δ16-12,20-Diketopregnenes

1963 ◽  
Vol 85 (12) ◽  
pp. 1844-1850 ◽  
Author(s):  
Monroe E. Wall ◽  
Samuel. Serota ◽  
Harold E. Kenney ◽  
G. Shuford. Abernethy
Keyword(s):  
Michael Addition ◽  
Aldol Condensation ◽  
Condensation Reaction

ChemInform Abstract: Gallium(III)- and Calcium(II)-Catalyzed Meyer-Schuster Rearrangements Followed by Intramolecular Aldol Condensation or endo-Michael Addition.

ChemInform ◽  
2015 ◽  
Vol 46 (31) ◽  
pp. no-no
Author(s):  
M. Presset ◽  
B. Michelet ◽  
R. Guillot ◽  
C. Bour ◽  
S. Bezzenine-Lafollee ◽  
...  
Keyword(s):  
Michael Addition ◽  
Aldol Condensation
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