Construction of sulfur-containing compounds with anti-cancer stem cell activity using thioacrolein derived from garlic based on nature-inspired scaffolds

2022 ◽  
Author(s):  
Taichi Yoneda ◽  
Naoto Kojima ◽  
Takahiro Matsumoto ◽  
Daisuke Imahori ◽  
Tomoe Ohta ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Activity ◽  
Alder Reaction ◽  
Diels Alder ◽  
Diels Alder Reaction ◽  
Anti Cancer ◽  
Stem Cell Activity ◽  
First Time ◽  
Sulfur Containing ◽  
Sulfur Containing Compounds

We reported for the first time that thioacroleinproduced by allicin, a major component in garlic, undergoes the regioselective sequential double Diels–Alder reaction.

The palladacycle, AJ-5, exhibits anti-tumour and anti-cancer stem cell activity in breast cancer cells

2015 ◽  
Vol 357 (1) ◽  
pp. 206-218 ◽  
Author(s):  
Saeb Aliwaini ◽  
Jade Peres ◽  
Wendy L. Kröger ◽  
Angelique Blanckenberg ◽  
Jo de la Mare ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Cell Activity ◽  
Anti Cancer ◽  
Stem Cell Activity

Ring-Closing Metathesis Approach to Cage Propellanes Containing Oxepane and Tetrahydrofuran Hybrid System

Synthesis ◽  
2017 ◽  
Vol 49 (24) ◽  
pp. 5339-5350 ◽  
Author(s):  
Sambasivarao Kotha ◽  
Subba Cheekatla ◽  
Darshan Mhatre
Keyword(s):  
Claisen Rearrangement ◽  
Alder Reaction ◽  
Diels Alder ◽  
Ring Closing Metathesis ◽  
Cage Compounds ◽  
Transannular Cyclization ◽  
Diels Alder Reaction ◽  
Grignard Addition ◽  
Key Steps ◽  
First Time

The preparation of a variety of structurally interesting oxygenated cage compounds involving atom-economic processes such as Claisen rearrangement, Diels–Alder reaction, [2+2] photocycloaddition, and ring-closing metathesis (RCM) as key steps is reported. For the first time, oxepane ring system is introduced in cage framework using olefin metathesis as a key step. These cage systems assembled here are difficult to prepare by traditional methods. The synthetic sequence described here opens up new routes to higher order polycycles containing heteroatoms without the involvement of protecting groups. Transannular cyclization observed during Grignard addition and the RCM protocol used here may be applicable to generate unknown oxygenated cage systems.

scholarly journals Assessment of potential anti-cancer stem cell activity of marine algal compounds using an in vitro mammosphere assay

2013 ◽  
Vol 13 (1) ◽  
pp. 39 ◽  
Author(s):  
Jo-Anne de la Mare ◽  
Jason N Sterrenberg ◽  
Mugdha G Sukhthankar ◽  
Maynard T Chiwakata ◽  
Denzil R Beukes ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cell Activity ◽  
Anti Cancer ◽  
Stem Cell Activity ◽  
Marine Algal ◽  
Mammosphere Assay

scholarly journals Anti-cancer stem cell activity of a sesquiterpene lactone isolated from Ambrosia arborescens and of a synthetic derivative

PLoS ONE ◽  
2017 ◽  
Vol 12 (9) ◽  
pp. e0184304 ◽  
Author(s):  
Wendy Soria Sotillo ◽  
Rodrigo Villagomez ◽  
Sandra Smiljanic ◽  
Xiaoli Huang ◽  
Atena Malakpour ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cancer Stem Cell ◽  
Sesquiterpene Lactone ◽  
Cell Activity ◽  
Anti Cancer ◽  
Stem Cell Activity ◽  
Synthetic Derivative

A new route for the synthesis of highly substituted 4-aminoquinoline drug like molecules via aza hetero–Diels–Alder reaction

2015 ◽  
Vol 13 (28) ◽  
pp. 7614-7618 ◽  
Author(s):  
Shinde Vidyacharan ◽  
A. Sagar ◽  
Duddu S. Sharada
Keyword(s):  
Alder Reaction ◽  
Diels Alder ◽  
Diels Alder Reaction ◽  
First Time

A new route has been developed for the synthesis of 4-aminoquinoline drug like moleculesviaaza hetero–Diels–Alder reaction starting from 2H-indazole as a diene for the first time.

Evaluation of anti-cancer stem cell activity of the anti-DLL4 antibody MEDI0639 in a phase I clinical trial of SCLC.

2016 ◽  
Vol 34 (15_suppl) ◽  
pp. e20093-e20093 ◽  
Author(s):  
Haifeng Bao ◽  
Xiaoru Chen ◽  
Suneetha Thomas ◽  
Xiaoqing Shi ◽  
Patrick Strout ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Phase I ◽  
Cell Activity ◽  
Phase I Clinical Trial ◽  
Anti Cancer ◽  
Stem Cell Activity
Sign in / Sign up

Export Citation Format

Share Document