Synthesis of 6-phenylbenzo[h]quinolines via photoinduced dehydrogenative annulation of (E)-2-phenyl-3-styrylpyridines

2021 ◽  
Vol 19 (39) ◽  
pp. 8554-8558
Author(s):  
Lixin Niu ◽  
Yun He ◽  
Jin Xi ◽  
Tao Wang ◽  
Yong Liang ◽  
...  
Keyword(s):  
Transition Metal ◽  
Efficient Method ◽  
Metal Catalyst ◽  
Reaction Conditions ◽  
Transition Metal Catalyst ◽  
Simple Operation ◽  
Catalyst Free ◽  
Free Process

A efficient method for the synthesis of 6-phenylbenzo[h]quinolines 2 has been developed. This strategy has the prominent advantages of simple operation, mild reaction conditions, high atom efficiency, and transition-metal/catalyst-free process.

scholarly journals Transition Metal Catalyst‐Free, Base‐Promoted 1,2‐Additions of Polyfluorophenylboronates to Aldehydes and Ketones

2021 ◽  
Author(s):  
Zhiqiang Liu ◽  
Goutam Kumar Kole ◽  
Yudha P. Budiman ◽  
Ya-Ming Tian ◽  
Alexandra Friedrich ◽  
...  
Keyword(s):  
Transition Metal ◽  
Metal Catalyst ◽  
Free Base ◽  
Transition Metal Catalyst ◽  
Catalyst Free ◽  
Aldehydes And Ketones

Synthesis of N-Aryl-4-arylhexahydroquinoline Derivatives by Reaction of Cyclic Enaminones with Arylidenemalononitriles in DMSO

Synthesis ◽  
2020 ◽  
Author(s):  
Takeshi Oriyama ◽  
Wei Han ◽  
Chika Inoue ◽  
Tsunaki Onizawa
Keyword(s):  
Transition Metal ◽  
Dimethyl Sulfoxide ◽  
Molecular Sieves ◽  
Metal Catalyst ◽  
Reaction Conditions ◽  
Transition Metal Catalyst ◽  
Cyclic Enaminones ◽  
High Yields

AbstractThe reaction of cyclic enaminones with arylidenemalono­nitriles was carried out in the presence of 13X molecular sieves in dimethyl sulfoxide. Under these mild reaction conditions, various bioactive N-aryl-4-arylhexahydroquinoline derivatives were obtained in high yields without the necessity of using transition-metal catalyst, organobase, or reflux conditions.

scholarly journals Iron-Catalyzed Silylation of Alcohols by Transfer Hydrosilylation with Silyl Formates

Synlett ◽  
2017 ◽  
Vol 28 (18) ◽  
pp. 2473-2477 ◽  
Author(s):  
Thibault Cantat ◽  
Timothé Godou ◽  
Clément Chauvier ◽  
Pierre Thuéry
Keyword(s):  
Transition Metal ◽  
Iron Catalyst ◽  
Metal Catalyst ◽  
Reaction Conditions ◽  
Transition Metal Catalyst ◽  
Earth Abundant ◽  
First Time

An iron catalyst is shown for the first time to promote transfer hydrosilylation with silyl formates and is utilized for the silylation of alcohols. Attractive features of this protocol include the use of an earth-abundant transition-metal catalyst, mild reaction conditions, and the release of gases as the only byproducts (H2 and CO2).

Micelle-Mediated Chemistry in Water for the Synthesis of Drug Candidates

Synthesis ◽  
2019 ◽  
Vol 51 (13) ◽  
pp. 2632-2647 ◽  
Author(s):  
Alan Steven
Keyword(s):  
Pharmaceutical Industry ◽  
Transition Metal ◽  
Critical Evaluation ◽  
Metal Catalyst ◽  
Catalyst Loading ◽  
Sonogashira Coupling ◽  
Reaction Conditions ◽  
Transition Metal Catalyst ◽  
Drug Candidates ◽  
Nitro Reduction

Micellar reaction conditions, in a predominantly aqueous medium, have been developed for transformations commonly used by synthetic chemists working in the pharmaceutical industry to discover and develop drug candidates. The reactions covered in this review are the Suzuki–Miyaura, Miyaura borylation, Sonogashira coupling, transition-metal-catalysed CAr–N coupling, SNAr, amidation, and nitro reduction. Pharmaceutically relevant examples of these applications will be used to show how micellar conditions can offer advantages in yield, operational ease, amount of waste generated, transition-metal catalyst loading, and safety over the use of organic solvents, irrespective of the setting in which they are used.1 Introduction2 Micelles as Solubilising Agents3 Micelles as Nanoreactors4 Designer Surfactants5 A Critical Evaluation of the Case for Chemistry in Micelles6 Scope of Review7 Suzuki–Miyaura Coupling8 Miyaura Borylation9 Sonogashira Coupling10 Transition-Metal-Catalysed CAr–N Couplings11 SNAr12 Amidation13 Nitro Reduction14 Micellar Sequences15 Summary and Outlook

Visible Light and Hydroxynaphthylbenzimidazoline Promoted Transition-Metal-Catalyst-Free Desulfonylation of N-Sulfonylamides and N-Sulfonylamines

2018 ◽  
Vol 83 (18) ◽  
pp. 10813-10825 ◽  
Author(s):  
Eietsu Hasegawa ◽  
Yuto Nagakura ◽  
Norihiro Izumiya ◽  
Keisuke Matsumoto ◽  
Tsukasa Tanaka ◽  
...  
Keyword(s):  
Transition Metal ◽  
Visible Light ◽  
Metal Catalyst ◽  
Transition Metal Catalyst ◽  
Catalyst Free
Sign in / Sign up

Export Citation Format

Share Document