scholarly journals Facilitating functionalization of benzene-1,3,5-tricarboxamides by switching amide connectivity

2021 ◽  
Vol 19 (38) ◽  
pp. 8281-8294
Author(s):  
Sandra M. C. Schoenmakers ◽  
Bart W. L. van den Bersselaar ◽  
Shikha Dhiman ◽  
Lu Su ◽  
Anja R. A. Palmans
Keyword(s):  
Functional Groups ◽  
Side Chain ◽  
Supramolecular Polymers ◽  
Supramolecular Motifs ◽  
Selective Functionalization

Selective functionalization of C3-symmetrical supramolecular motifs was achieved by switching the amide connectivity of one side chain, yielding supramolecular polymers with a tunable number of functional groups.

scholarly journals Synthesis and Biological Activity of Brassinosteroid Analogues with a Nitrogen-Containing Side Chain

2020 ◽  
Vol 22 (1) ◽  
pp. 155
Author(s):  
Mikhail V. Diachkov ◽  
Karoll Ferrer ◽  
Jana Oklestkova ◽  
Lucie Rarova ◽  
Vaclav Bazgier ◽  
...  
Keyword(s):  
Biological Activity ◽  
Functional Groups ◽  
Side Chain ◽  
Biotic And Abiotic Stresses ◽  
Short Side ◽  
Arabidopsis Root ◽  
Physiological Processes ◽  
Growth Promoting ◽  
The Impact ◽  
Brassinosteroid Analogues

Brassinosteroids are a class of plant hormones that regulate a broad range of physiological processes such as plant growth, development and immunity, including the suppression of biotic and abiotic stresses. In this paper, we report the synthesis of new brassinosteroid analogues with a nitrogen-containing side chain and their biological activity on Arabidopis thaliana. Based on molecular docking experiments, two groups of brassinosteroid analogues were prepared with short and long side chains in order to study the impact of side chain length on plants. The derivatives with a short side chain were prepared with amide, amine and ammonium functional groups. The derivatives with a long side chain were synthesized using amide and ammonium functional groups. A total of 25 new brassinosteroid analogues were prepared. All 25 compounds were tested in an Arabidopsis root sensitivity bioassay and cytotoxicity screening. The synthesized substances showed no significant inhibitory activity compared to natural 24-epibrassinolide. In contrast, in low concentration, several compounds (8a, 8b, 8e, 16e, 22a and 22e) showed interesting growth-promoting activity. The cytotoxicity assay showed no toxicity of the prepared compounds on cancer and normal cell lines.

scholarly journals Unsymmetrical Difunctionalization of Two Different C–H Bonds in One Pot Under Transition-Metal Catalysis

Synthesis ◽  
2018 ◽  
Vol 51 (01) ◽  
pp. 40-54 ◽  
Author(s):  
Masahito Murai ◽  
Kazuhiko Takai
Keyword(s):  
Transition Metal ◽  
Functional Groups ◽  
Aromatic Compounds ◽  
Transition Metal Catalysis ◽  
One Pot ◽  
Metal Catalysis ◽  
Selective Functionalization ◽  
Sequential Addition ◽  
Target Molecules ◽  
Directing Group

Recent advancements in unsymmetrical difunctionalization based on the substitution of two different C–H bonds in one-pot are described. Due to the difficulty of controlling reactivity and selectivity, multi-functionalization via substitution of several C–H bonds to install different functional groups has been limited until recently, in comparison with well-studied functionalization via sequential addition to unsaturated π-bonds. This difunctionalization protocol provides an efficient and rapid approach to a library of structurally complicated target molecules through the formation of multiple C–X bonds with high atom- and step-economy.1 Introduction2 ortho-Selective Functionalization of Two Different C–H Bonds Relative to the Directing Group2.1 Unsymmetrical Difunctionalization with the Introduction of Similar Functional Groups2.2 Unsymmetrical Difunctionalization with the Introduction of Different Functional Groups2.3 ortho-Selective Unsymmetrical Difunctionalization Promoted by Two Different Directing Groups Appearing During the Progress of the Reaction3 ortho/meta-Selective C–H Bond Difunctionalization Relative to the Directing Group4 Sequential Difunctionalization of Fused Aromatic Compounds and Heterocycles5 Summary and Outlook

Conjugated electrochromic polymers with amide-containing side chains enabling aqueous electrolyte compatibility

2020 ◽  
Vol 11 (2) ◽  
pp. 508-516 ◽  
Author(s):  
Kuluni Perera ◽  
Zhengran Yi ◽  
Liyan You ◽  
Zhifan Ke ◽  
Jianguo Mei
Keyword(s):  
Functional Groups ◽  
Aqueous Electrolyte ◽  
Side Chain ◽  
Side Chains ◽  
Electrochromic Polymers

This work illustrates an effective side-chain modification approach using amide functional groups to induce aqueous electroactivity to ProDOT-based electrochromic polymers.

scholarly journals Side-Chain Supramolecular Polymers Employing Conformer Independent Triple Hydrogen Bonding Arrays

2013 ◽  
Vol 46 (24) ◽  
pp. 9634-9641 ◽  
Author(s):  
Adam Gooch ◽  
Natasha S. Murphy ◽  
Neil H. Thomson ◽  
Andrew J. Wilson
Keyword(s):  
Hydrogen Bonding ◽  
Side Chain ◽  
Supramolecular Polymers

Research on FTIR Analysis of Populus nigra L. Lignin Structure Changes in Different Bleaching Processes

2011 ◽  
Vol 236-238 ◽  
pp. 1283-1287
Author(s):  
Qiang Zhao ◽  
De Zhi Sun ◽  
Jun Wen Pu ◽  
Xiao Juan Jin ◽  
Mian Xing
Keyword(s):  
Carbonyl Group ◽  
Functional Groups ◽  
Populus Nigra ◽  
Side Chain ◽  
Ftir Analysis ◽  
Bleaching Process ◽  
Ether Bond ◽  
Bleaching Efficiency ◽  
Structure Changes ◽  
Alcoholic Hydroxyl

To study the bleaching mechanisms of H2O2 bleaching, H2O2 displacement bleaching and H2O2 /TAED bleaching, three kinds of lignin bleached with above processes were obtained. Three types of treated Populus nigra L lignins structure were identified and the functional groups were quantitied by FTIR. In contrast, the deacetylation and the breakage of ester bonds in H2O2/TAED bleaching system was much more significant. The total carbonyl group of H2O2 bleached lignin decreased 6.6% while displacement bleached lignin and H2O2/TAED bleached lignin decreased 9.2% and 15.8% respectively. The PT bleaching process had stronger oxidability to destroy the syringyl units in lignin. The breakage of ether bonds and alcoholic hydroxyl dehydration in side chain increased after bleaching. In contrast, the stronger destroyed effection on guaiacyl dialkyl ether bond with PT bleaching processes. The conclusions obtained may interpret H2O2 displacementbleaching and H2O2/TAED bleaching systems have better bleaching efficiency than H2O2 bleachingsystem.

Pteridines CX

Pteridines ◽  
1999 ◽  
Vol 10 (3) ◽  
pp. 79-90 ◽  
Author(s):  
Hermann Traub ◽  
Wolfgang Pfleiderer
Keyword(s):  
Functional Groups ◽  
Side Chain ◽  
Amino Group ◽  
Nucleophilic Displacement ◽  
Acid And Base ◽  
Displacement Reactions ◽  
Amide Acetals

Summary A series of new 6-substituted 2,4-diaminopteridines (3-23) and pterins (26-43) have been synthesized by nucleophilic displacement reactions at the side chain of 6-bromomethyl-2,4-diaminopteridine (2) and 6- bromomethylpterin (25) using various types of 0-, N- and S-nucleophiles. Acid and base hydrolyses allow easy conversion of the 2,4-diaminopteridines (3-5, 7, 9, 10, 12, 19-21 and 23) into the corresponding pterins (26-32, 39-42). Acylations take place at the amino as well as at the functional groups in the side chain (44-46). A versatile protection of the amino group in pterins is its transformation into the N ,N -dimethylaminomethylcnimino function by amide-acetals (47, 50) allowing subsequently selective acylations at the side chain (48, 49).

ChemInform Abstract: 1-Boraadamantane Derivatives with Functional Groups in the Side Chain.

ChemInform ◽  
2010 ◽  
Vol 22 (41) ◽  
pp. no-no
Author(s):  
YU. N. BUBNOV ◽  
T. V. POTAPOVA ◽  
M. E. GURSKII
Keyword(s):  
Functional Groups ◽  
Side Chain

scholarly journals Effect of side chain functional groups on inclusion abilities of cholic acid

2002 ◽  
Vol 58 (s1) ◽  
pp. c141-c141
Author(s):  
N. Yoswathananont ◽  
K. Nakano ◽  
K. Sada ◽  
M. Miyata
Keyword(s):  
Cholic Acid ◽  
Functional Groups ◽  
Side Chain
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