Enzymatic modular assembly of hybrid Lewis antigens

2021 ◽  
Vol 19 (37) ◽  
pp. 8041-8048
Author(s):  
Hui Xia ◽  
Jinfeng Ye ◽  
Hongzhi Cao ◽  
Xianwei Liu ◽  
Yan Zhang ◽  
...  
Keyword(s):  
Lewis Antigens ◽  
Modular Assembly ◽  
Complex Hybrid

Facile enzymatic modular assembly of 3 complex hybrid Lewis antigens.

Creation and evaluation of new varieties and populations of alfalfa

2020 ◽  
Author(s):  
I. A. Meremyanina I. A. ◽  
◽  
V.V. Kenyz V.V.
Keyword(s):  
High Productivity ◽  
Green Mass ◽  
Economically Valuable Traits ◽  
New Varieties ◽  
Complex Hybrid ◽  
The Creation

The article is based on the creation and evaluation of new varieties and complex hybrid populations of alfalfa with economically valuable traits and properties.Varieties with high productivity of green mass and seeds have been created and studied.

Hydrogel-clay Nanocomposites as Carriers for Controlled Release

2020 ◽  
Vol 27 (6) ◽  
pp. 919-954 ◽  
Author(s):  
Raluca Ianchis ◽  
Claudia Mihaela Ninciuleanu ◽  
Ioana Catalina Gifu ◽  
Elvira Alexandrescu ◽  
Cristina Lavinia Nistor ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Hybrid Materials ◽  
Pharmaceutical Formulations ◽  
Tree Of Life ◽  
Present Review ◽  
Clay Nanocomposites ◽  
Delivery Platform ◽  
Complex Hybrid

The present review aims to summarize the research efforts undertaken in the last few years in the development and testing of hydrogel-clay nanocomposites proposed as carriers for controlled release of diverse drugs. Their advantages, disadvantages and different compositions of polymers/biopolymers with diverse types of clays, as well as their interactions are discussed. Illustrative examples of studies regarding hydrogel-clay nanocomposites are detailed in order to underline the progressive researches on hydrogel-clay-drug pharmaceutical formulations able to respond to a series of demands for the most diverse applications. Brief descriptions of the different techniques used for the characterization of the obtained complex hybrid materials such as: swelling, TGA, DSC, FTIR, XRD, mechanical, SEM, TEM and biology tests, are also included. Enlightened by the presented data, we can suppose that hydrogel-clay nanocomposites will still be a challenging subject of global assiduous researches. We can dare to dream to an efficient drug delivery platform for the treatment of multiple affection concomitantly, these being undoubtedly like ”a tree of life” bearing different kinds of fruits and leaves proper for human healing.

scholarly journals Influence of protein (human galectin-3) design on aspects of lectin activity

2020 ◽  
Vol 154 (2) ◽  
pp. 135-153 ◽  
Author(s):  
Gabriel García Caballero ◽  
Donella Beckwith ◽  
Nadezhda V. Shilova ◽  
Adele Gabba ◽  
Tanja J. Kutzner ◽  
...  
Keyword(s):  
Protein Design ◽  
Full Range ◽  
Biological Information ◽  
The Novel ◽  
Modular Assembly ◽  
Binding Partners ◽  
Galectin 3 ◽  
Potential Applications ◽  
Similar Affinity

Abstract The concept of biomedical significance of the functional pairing between tissue lectins and their glycoconjugate counterreceptors has reached the mainstream of research on the flow of biological information. A major challenge now is to identify the principles of structure–activity relationships that underlie specificity of recognition and the ensuing post-binding processes. Toward this end, we focus on a distinct feature on the side of the lectin, i.e. its architecture to present the carbohydrate recognition domain (CRD). Working with a multifunctional human lectin, i.e. galectin-3, as model, its CRD is used in protein engineering to build variants with different modular assembly. Hereby, it becomes possible to compare activity features of the natural design, i.e. CRD attached to an N-terminal tail, with those of homo- and heterodimers and the tail-free protein. Thermodynamics of binding disaccharides proved full activity of all proteins at very similar affinity. The following glycan array testing revealed maintained preferential contact formation with N-acetyllactosamine oligomers and histo-blood group ABH epitopes irrespective of variant design. The study of carbohydrate-inhibitable binding of the test panel disclosed up to qualitative cell-type-dependent differences in sections of fixed murine epididymis and especially jejunum. By probing topological aspects of binding, the susceptibility to inhibition by a tetravalent glycocluster was markedly different for the wild-type vs the homodimeric variant proteins. The results teach the salient lesson that protein design matters: the type of CRD presentation can have a profound bearing on whether basically suited oligosaccharides, which for example tested positively in an array, will become binding partners in situ. When lectin-glycoconjugate aggregates (lattices) are formed, their structural organization will depend on this parameter. Further testing (ga)lectin variants will thus be instrumental (i) to define the full range of impact of altering protein assembly and (ii) to explain why certain types of design have been favored during the course of evolution, besides opening biomedical perspectives for potential applications of the novel galectin forms.

Modular assembly of enzyme loaded nanoparticles in 3D hollow fiber electrode for electrochemical sensing

2021 ◽  
pp. 129721
Author(s):  
Huimin Wu ◽  
Xinran Zhang ◽  
Chenjie Wei ◽  
Chengcheng Wang ◽  
Min Jiang ◽  
...  
Keyword(s):  
Hollow Fiber ◽  
Electrochemical Sensing ◽  
Modular Assembly ◽  
Fiber Electrode

Insight into the tannic acid-based modular-assembly strategy based on inorganic–biological hybrid systems: a material suitability, loading effect, and biocompatibility study

2021 ◽  
Author(s):  
Xiaoning Ren ◽  
Panqing Yin ◽  
Jun Liang ◽  
Xiangjian Liu ◽  
Wugen Zhan ◽  
...  
Keyword(s):  
Hybrid Systems ◽  
Tannic Acid ◽  
Modular Assembly ◽  
Loading Effect ◽  
Assembly Strategy ◽  
Biocompatibility Study ◽  
Insight Into

The tannic acid-based modular-assembly strategy for building inorganic–biological hybrids is studied regarding the aspects of the material suitability, loading effect, and biocompatibility.

Characterisation of novel regulatory sequences compatible with modular assembly in the diatom Phaeodactylum tricornutum

2021 ◽  
Vol 53 ◽  
pp. 102159
Author(s):  
Matthias Windhagauer ◽  
Raffaela M. Abbriano ◽  
Justin Ashworth ◽  
Lorenzo Barolo ◽  
Ana Cristina Jaramillo-Madrid ◽  
...  
Keyword(s):  
Phaeodactylum Tricornutum ◽  
Regulatory Sequences ◽  
Modular Assembly

Actor-Network Theory Contract Theory

2020 ◽  
Vol 16 (1) ◽  
pp. 74-94
Author(s):  
Mika Viljanen
Keyword(s):  
Empirical Evidence ◽  
Network Theory ◽  
Contract Theory ◽  
Actor Network Theory ◽  
Small Scale ◽  
Governance Structures ◽  
Actor Network ◽  
Hybrid Governance ◽  
Conceptual Innovation ◽  
Complex Hybrid

AbstractFirms increasingly use complex hybrid governance structures to manage value generation networks. Empirical evidence demonstrates that the structures contain soft, “enforcement-challenged” contractual devices. Existing contract theories, however, fail to recognize and explain how these soft contract devices work as legal devices. The article seeks to address this failure.The article uses a conceptual innovation by Schepker et al to construct an actor-network theory (ANT) inspired contract theory. Schepker et al argued that contracts are best understood as often concurrently serving safeguarding, coordination, and adaptation goals. The article argues that combined with ANT the functional contracting frame allows us to recognize that contracts work and gain efficacy in multiple ways. To understand how the soft, “enforcement-challenged” contract devices work, the article traces the efficacy mechanisms the devices perform and enact.The tracings lead the article to propose an ANT contract theory that builds on three intertwined ideas: 1) contract devices have no core efficacy networks but multiple parallel efficacies, 2) contracts should be understood as bricolage collages of small-scale contractual point intervention devices that each deploy and rely on their own efficacy mechanisms and patterns, and 3) the force of contract resides in the socio-material assemblages contracts are capable of creating and sustaining.

scholarly journals Ultra-Portable Smartphone Controlled Integrated Digital Microfluidic System in a 3D-Printed Modular Assembly

Micromachines ◽  
2015 ◽  
Vol 6 (9) ◽  
pp. 1289-1305 ◽  
Author(s):  
Mohamed Yafia ◽  
Ali Ahmadi ◽  
Mina Hoorfar ◽  
Homayoun Najjaran
Keyword(s):  
Microfluidic System ◽  
Modular Assembly ◽  
3D Printed ◽  
Digital Microfluidic
Sign in / Sign up

Export Citation Format

Share Document