Ligand-free copper-catalyzed borylative defluorination: access to gem-difluoroallyl boronic acid derivatives

2021 ◽  
Author(s):  
Ashley M. Gates ◽  
Swetha Jos ◽  
Webster L. Santos
Keyword(s):  
Boronic Acid ◽  
Unsaturated Esters ◽  
Ligand Free ◽  
Boronic Acid Derivatives

We report a ligand-free copper-catalyzed β-borylation, defluorination of β-substituted, α-trifluoromethyl-α,β-unsaturated esters.

Synthesis of Sugar–Boronic Acid Derivatives: A Class of Potential Agents for Boron Neutron Capture Therapy

2017 ◽  
Vol 19 (7) ◽  
pp. 1678-1681 ◽  
Author(s):  
Daniela Imperio ◽  
Erika Del Grosso ◽  
Silvia Fallarini ◽  
Grazia Lombardi ◽  
Luigi Panza
Keyword(s):  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Boronic Acid ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture ◽  
Boronic Acid Derivatives

Recognition and sensing of various species using boronic acid derivatives

2012 ◽  
Vol 48 (48) ◽  
pp. 5956 ◽  
Author(s):  
Zhiqian Guo ◽  
Injae Shin ◽  
Juyoung Yoon
Keyword(s):  
Boronic Acid ◽  
Boronic Acid Derivatives

The modern role of boron as a 'magic element' in biomedical science: Chemistry perspective

2021 ◽  
Author(s):  
SAURAV CHATTERJEE ◽  
NITESH MANI Mani TRIPATHI ◽  
Anupam Bandyopadhyay
Keyword(s):  
Drug Discovery ◽  
Boronic Acid ◽  
Toxic Element ◽  
Biomedical Science ◽  
Boronic Acid Derivatives

The boron was misconstrued as a toxic element for animals, which retarded the growth of boron-containing drug discovery in the last century. Nevertheless, modern applications of boronic acid derivatives are...

scholarly journals Rapid approach to complex boronic acids

2019 ◽  
Vol 5 (7) ◽  
pp. eaaw4607 ◽  
Author(s):  
Constantinos G. Neochoritis ◽  
Shabnam Shaabani ◽  
Maryam Ahmadianmoghaddam ◽  
Tryfon Zarganes-Tzitzikas ◽  
Li Gao ◽  
...  
Keyword(s):  
Small Molecules ◽  
Boronic Acid ◽  
Multicomponent Reactions ◽  
Chemical Space ◽  
Building Blocks ◽  
Acid Synthesis ◽  
Success Rates ◽  
Boronic Acid Derivatives ◽  
Low Coverage ◽  
Target Synthesis

The compatibility of free boronic acid building blocks in multicomponent reactions to readily create large libraries of diverse and complex small molecules was investigated. Traditionally, boronic acid synthesis is sequential, synthetically demanding, and time-consuming, which leads to high target synthesis times and low coverage of the boronic acid chemical space. We have performed the synthesis of large libraries of boronic acid derivatives based on multiple chemistries and building blocks using acoustic dispensing technology. The synthesis was performed on a nanomole scale with high synthesis success rates. The discovery of a protease inhibitor underscores the usefulness of the approach. Our acoustic dispensing–enabled chemistry paves the way to highly accelerated synthesis and miniaturized reaction scouting, allowing access to unprecedented boronic acid libraries.

Asymmetric Synthesis of Protected α-Amino Boronic Acid Derivatives with an Air- and Moisture-Stable Cu(II) Catalyst

2014 ◽  
Vol 79 (8) ◽  
pp. 3671-3677 ◽  
Author(s):  
Andrew W. Buesking ◽  
Vlad Bacauanu ◽  
Irene Cai ◽  
Jonathan A. Ellman
Keyword(s):  
Asymmetric Synthesis ◽  
Boronic Acid ◽  
Boronic Acid Derivatives

scholarly journals Organic photocatalysis for the radical couplings of boronic acid derivatives in batch and flow

2018 ◽  
Vol 54 (44) ◽  
pp. 5606-5609 ◽  
Author(s):  
Fabio Lima ◽  
Lars Grunenberg ◽  
Husaini B. A. Rahman ◽  
Ricardo Labes ◽  
Joerg Sedelmeier ◽  
...  
Keyword(s):  
Boronic Acid ◽  
Boronic Acid Derivatives

A convenient organo-photocataytic approach to the radical couplings of boronic acid derivatives is described and applied for APIs synthesis.

Copper(ii)-catalyzed protoboration of allenes in aqueous media and open air

2021 ◽  
Author(s):  
Russell F. Snead ◽  
Jan Nekvinda ◽  
Webster L. Santos
Keyword(s):  
Boronic Acid ◽  
Room Temperature ◽  
Aqueous Media ◽  
Boronic Acid Derivatives

A copper(ii)-catalyzed internal protoboration of monosubstituted allenes efficiently occurs in water at room temperature and open air to generate 1,1-disubstituted vinyl boronic acid derivatives.

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