Recent Advances in Synthesis of Indolizine and its Derivatives by Radical Cyclization/Cross-Coupling

2021 ◽  
Author(s):  
Jieru Hui ◽  
Yanlong Ma ◽  
Jiaji Zhao ◽  
Hua Cao
Keyword(s):  
Biological Activities ◽  
Cross Coupling ◽  
Radical Cyclization ◽  
Fluorescence Properties ◽  
Recent Advances

Abstract: Indolizine as a member of nitrogen-containing heterocycles has a variety of potential biological activities, and even some indolizine derivatives with excellent fluorescence properties can be used as organic fluorescent...

Withdrawal Notice: Recent Advances in Sonogashira Cross-Coupling Reactions Under Solvent-Free Conditions

2020 ◽  
Vol 24 ◽  
Author(s):  
Teng Wang ◽  
Zongrui Liu ◽  
Songlin Wang ◽  
Esmail Vessally
Keyword(s):  
Organic Chemistry ◽  
Editorial Policy ◽  
Cross Coupling ◽  
Solvent Free ◽  
Coupling Reactions ◽  
Editorial Policies ◽  
Cross Coupling Reactions ◽  
Recent Advances ◽  
Solvent Free Conditions ◽  
Copyright Permission

The article has been withdrawn at the request of editor of the journal Current Organic Chemistry: Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused. The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php BENTHAM SCIENCE DISCLAIMER: It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the authors, if plagiarism or fabricated information is discovered. By submitting a manuscript, the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.

Recent Advances in Group 14 Cross-Coupling: Si and Ge-Based Alternatives to the Stille Reaction

2004 ◽  
Vol 1 (3) ◽  
pp. 211-226 ◽  
Author(s):  
Alan Spivey ◽  
Christopher Gripton ◽  
Joseph Hannah
Keyword(s):  
Cross Coupling ◽  
Stille Reaction ◽  
Group 14 ◽  
Recent Advances

Synthetic Strategies, Chemical Reactivities and Biological Activities of 3-Thioxo-1,2,4-Triazin-5-Ones and Their Derivatives

2019 ◽  
Vol 16 (4) ◽  
pp. 308-322
Author(s):  
Mohammad S.T. Makki ◽  
Reda M. Abdel-Rahman ◽  
Abdulrahman S. Alharbi
Keyword(s):  
Biological Activities ◽  
Biological Evaluation ◽  
Literature Survey ◽  
Recent Advances ◽  
Nucleophilic Reagents ◽  
Anti Hiv ◽  
Biological Field

In recent years, a very interest in the synthesis of functionalized 3-thioxo-1,2,4-triazin-5- ones and their derivatives as vital probes has been increased, due to the important, applications of the medicinal, pharmacological, and biological field as a drug, semi drug, and bioactive systems. The present work review outlines extensive recent advances literature survey on the synthesis of sulfurbearing 1,2,4-triazin-5-one derivatives has been reconsidered. Also, the behavior of these family towards electrophilic and nucleophilic reagents in different media and conditions reported. The biological evaluation of the most synthesized systems included anticancer, anti-HIV, antimicrobial as well as their enzymatic effects (cellobiase produced by fungi) have been reported. The reactivity of these systems depends on the polarity of solvent, temperature, molarity as well as a type of tautomeric present.

Recent Advances in C–Br Bond Formation

Synlett ◽  
2021 ◽  
Author(s):  
Ying-Yeung Yeung ◽  
Jonathan Wong
Keyword(s):  
Organic Synthesis ◽  
Aromatic Compounds ◽  
Bond Formation ◽  
Cross Coupling ◽  
Catalytic Site ◽  
Atom Transfer ◽  
Bond Forming ◽  
Recent Advances ◽  
Catalytic Asymmetric ◽  
Site Selective

AbstractOrganobromine compounds are extremely useful in organic synthesis. In this perspective, a focused discussion on some recent advancements in C–Br bond-forming reactions is presented.1 Introduction2 Selected Recent Advances2.1 Catalytic Asymmetric Bromopolycyclization of Olefinic Substrates2.2 Catalytic Asymmetric Intermolecular Bromination2.3 Some New Catalysts and Reagents for Bromination2.4 Catalytic Site-Selective Bromination of Aromatic Compounds2.5 sp3 C–H Bromination via Atom Transfer/Cross-Coupling3 Outlook

Highly selective introduction of heteroatom groups to isocyanides and its application to electrocyclic reactions

2012 ◽  
Vol 85 (4) ◽  
pp. 785-799 ◽  
Author(s):  
Akiya Ogawa ◽  
Taichi Tamai ◽  
Takenori Mitamura ◽  
Akihiro Nomoto
Keyword(s):  
Cross Coupling ◽  
Molecular Iodine ◽  
Radical Cyclization ◽  
Sharp Contrast ◽  
Quinoline Derivatives ◽  
Coupling Reactions ◽  
Electrocyclic Reactions ◽  
Cross Coupling Reactions ◽  
Cyclization Process ◽  
Synthetic Intermediates

Photoinduced cyclization of o-alkenylaryl isocyanides with (PhS)2 in the presence of (PhTe)2 affords the corresponding bisthiolated indene derivatives in good yields via radical cyclization process by thio radical. The procedure can be applied to the construction of tetracyclic systems by using bis(o-aminophenyl) disulfides in place of (PhS)2. In sharp contrast, when o-alkynylaryl isocyanides are employed as the substrates, novel electrocyclic reactions take place upon photoirradiation or heating at 40~80 °C to generate quinoline 2,4-biradical species, which are trapped with organic diselenides, ditellurides, and molecular iodine to give the corresponding 2,4-diseleno-, ditelluro-, and diiodo-quinoline derivatives, respectively, in good yields. The obtained quinoline derivatives are useful synthetic intermediates; for example, cross-coupling reactions using 2,4-diiodoquinolines lead to the preparation of functionalized quinoline derivatives.

The presence of food-derived collagen peptides in human body-structure and biological activity

2017 ◽  
Vol 8 (12) ◽  
pp. 4325-4330 ◽  
Author(s):  
Kenji Sato
Keyword(s):  
Biological Activity ◽  
Human Body ◽  
Biological Activities ◽  
Body Structure ◽  
Collagen Peptides ◽  
Recent Advances

While it was difficult to detect food-derived peptide in blood (A), recent advances enables identify them (B) and examine their biological activities.

C1-Inhibitor: Structure, Functional Diversity and Therapeutic Development

2021 ◽  
Vol 28 ◽  
Author(s):  
Elena Karnaukhova
Keyword(s):  
Biochemical Characterization ◽  
Biological Activities ◽  
Serine Proteinase ◽  
Endotoxin Shock ◽  
C1 Inhibitor ◽  
Recent Advances ◽  
Therapeutic Development ◽  
Inhibitory Activities ◽  
Endogenous Proteins ◽  
C1inh Deficiency

: Human C1-Inhibitor (C1INH), also known as C1-esterase inhibitor, is an important multifunctional plasma glycoprotein that is uniquely involved in a regulatory network of complement, contact, coagulation, and fibrinolytic systems. C1INH belongs to a superfamily of serine proteinase inhibitor (serpins) and exhibits its inhibitory activities towards several target proteases of plasmatic cascades, operating as a major anti-inflammatory protein in the circulation. In addition to its inhibitory activities, C1INH is also involved in non-inhibitory interactions with some endogenous proteins, polyanions, cells and infectious agents. While C1INH is essential for multiple physiological processes, it is better known for its deficiency with regards to Hereditary Angioedema (HAE), a rare autosomal dominant disease clinically manifested by recurrent acute attacks of increased vascular permeability and edema. Since the link was first established between functional C1INH deficiency in plasma and HAE in the 1960s, tremendous progress has been made in the biochemical characterization of C1INH and its therapeutic development for replacement therapies in patients with C1INH-dependent HAE. Various C1INH biological activities, recent advances in the HAE-targeted therapies, and availability of C1INH commercial products have prompted intensive investigation of the C1INH potential for treatment of clinical conditions other than HAE. This article provides an updated overview of the structure and biological activities of C1INH, its role in HAE pathogenesis, and recent advances in the research and therapeutic development of C1INH; it also considers some trends for using C1INH therapeutic preparations for applications other than angioedema, from sepsis and endotoxin shock to severe thrombotic complications in COVID-19 patients.

Cross-Coupling Reactions with 2-Amino-/Acetylamino-Substituted 3-Iodo-1,4-naphthoquinones: Convenient Synthesis of Novel Alkenyl- and Alkynylnaphthoquinones and Derivatives

Synthesis ◽  
2021 ◽  
Author(s):  
Felipe C. Demidoff ◽  
Leandro L. de Carvalho ◽  
Eduardo José P. Rodrigues Filho ◽  
Andréa Luzia F. de Souza ◽  
Chaquip D. Netto
Keyword(s):  
Click Chemistry ◽  
Organic Synthesis ◽  
Biological Activities ◽  
Cross Coupling ◽  
Coupling Reactions ◽  
Large Array ◽  
Terminal Alkyne ◽  
Co Catalyst ◽  
Cross Coupling Reactions ◽  
Convenient Synthesis

AbstractFunctionalized 1,4-naphthoquinones have been employed as versatile synthons in organic synthesis, in addition to presenting a large array of biological activities. Herein, the applications of 2-amino-/ acetylamino-substituted 3-iodo-1,4-naphthoquinones in cross-coupling reactions are described to successfully afford sixteen novel 3-styryl-1,4-naphthoquinones (amino-stilbene-quinone hybrids) and four 3-alkynyl-1,4-naphthoquinone in overall good yields. Interestingly, the alkynylated derivatives could be obtained from ligand- and Pd-free CuI-mediated cross-coupling reactions, after extensive investigations to exclude Pd as a co-catalyst. Lastly, the desilanized terminal alkyne was subjected to click chemistry reactions to give two novel triazole-1,4-naphthoquinone hybrids.

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