Solitumergosterol A, a unique 6/6/6/6/5 steroid from the deep-sea-derived Penicillium solitum MCCC 3A00215

Organic & Biomolecular Chemistry ◽

10.1039/d1ob01392k ◽

2021 ◽

Author(s):

Zhihui He ◽

Chun-Lan Xie ◽

You-Jia Hao ◽

Lin Xu ◽

Chao-Feng Wang ◽

...

Keyword(s):

Deep Sea ◽

Planar Structure ◽

Relative Configuration ◽

Penicillium Solitum

A unique C30 steroid, solitumergosterol A (1), was isolated from the deep-sea-derived fungus Penicillium solitum MCCC 3A00215. The planar structure and relative configuration of 1 was established mainly on the...

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Chemical Constituents of the Deep-Sea-Derived Penicillium solitum

Marine Drugs ◽

10.3390/md19100580 ◽

2021 ◽

Vol 19 (10) ◽

pp. 580

Author(s):

Zhi-Hui He ◽

Jia Wu ◽

Lin Xu ◽

Man-Yi Hu ◽

Ming-Ming Xie ◽

...

Keyword(s):

Deep Sea ◽

Chemical Constituents ◽

A549 Cells ◽

Acid Methyl Ester ◽

2D Nmr ◽

Positive Control ◽

Ic50 Values ◽

Penicillium Solitum ◽

New Compounds

A systematic chemical investigation of the deep-sea-derived fungus Penicillium solitum MCCC 3A00215 resulted in the isolation of one novel polyketide (1), two new alkaloids (2 and 3), and 22 known (4–25) compounds. The structures of the new compounds were established mainly on the basis of exhaustive analysis of 1D and 2D NMR data. Viridicatol (13) displayed moderate anti-tumor activities against PANC-1, Hela, and A549 cells with IC50 values of around 20 μM. Moreover, 13 displayed potent in vitro anti-food allergic activity with an IC50 value of 13 μM, compared to that of 92 μM for the positive control, loratadine, while indole-3-acetic acid methyl ester (9) and penicopeptide A (10) showed moderate effects (IC50 = 50 and 58 μM, respectively).

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