Diastereoselective Synthesis of Spiro[carbazole-3,5'-pyrimidines] and Spiro[carbazole-3,1'-cyclohexanes] via Four-component Reaction

2021 ◽  
Author(s):  
Shao-Cong Zhan ◽  
Ren-Jie Fang ◽  
Jing Sun ◽  
Chaoguo Yan
Keyword(s):  
Aromatic Aldehyde ◽  
Multicomponent Reaction ◽  
Diastereoselective Synthesis

The functionalized spiro[carbazole-3,5'-pyrimidines] and spiro[carbazole-3,1'-cyclohexanes] were efficiently synthesized in satisfactory yields with high diastereoselectivity by CuSO4 catalyzed multicomponent reaction of indole-2-acetate, aromatic aldehyde and 1,3-dimethylbarbituric acid or dimedone. The reaction...

Enantio- and diastereoselective synthesis of spiropyrazolones via an organocatalytic [1 + 2 + 3] multicomponent reaction

2019 ◽  
Vol 17 (41) ◽  
pp. 9217-9225 ◽  
Author(s):  
Yan-Ling Ji ◽  
He-Ping Li ◽  
Yue-Yan Ai ◽  
Guo Li ◽  
Xiang-Hong He ◽  
...  
Keyword(s):  
Multicomponent Reaction ◽  
Diastereoselective Synthesis ◽  
Asymmetric Catalytic ◽  
High Yields

An asymmetric catalytic [1 + 2 + 3] multicomponent reaction of malononitrile, benzaldehyde and α-arylidene pyrazolinones to produce spiropyrazolones in high yields, with excellent enantioselectivities and good diastereoselectivities.

scholarly journals Diastereoselective Synthesis of Cyclopenta[c]furans by a Catalytic Multicomponent Reaction

2016 ◽  
Vol 128 (39) ◽  
pp. 12042-12045 ◽  
Author(s):  
Stalin R. Pathipati ◽  
Angela van der Werf ◽  
Lars Eriksson ◽  
Nicklas Selander
Keyword(s):  
Multicomponent Reaction ◽  
Diastereoselective Synthesis

Trialkylborane-Mediated Multicomponent Reaction for the Diastereoselective Synthesis of Anti-δ,δ-Disubstituted Homoallylic Alcohols

2018 ◽  
Vol 21 (2) ◽  
pp. 476-480 ◽  
Author(s):  
Yoshikazu Horino ◽  
Miki Murakami ◽  
Ataru Aimono ◽  
Jun Hee Lee ◽  
Hitoshi Abe
Keyword(s):  
Multicomponent Reaction ◽  
Diastereoselective Synthesis ◽  
Homoallylic Alcohols

scholarly journals Antimicrobial Activity of Some Derivatives of 1,4-Dihydropyridines

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Prabha Mehta ◽  
Prabha Verma
Keyword(s):  
Antimicrobial Activity ◽  
Minimum Inhibitory Concentration ◽  
Aromatic Aldehyde ◽  
Multicomponent Reaction ◽  
Inhibitory Concentration ◽  
Ammonium Hydroxide ◽  
Pharmacological Properties ◽  
Mueller Hinton ◽  
Derivatives Of ◽  
Mueller Hinton Broth

Hantzsch reported the synthesis of functionalized 1,4-dihydropyridines via three-component condensation of an aromatic aldehyde, ketoester, and ammonium hydroxide. This multicomponent reaction is of much importance due to excellent pharmacological properties of dihydropyridines. In this account, we synthesized some halo- and nitrophenyl dihydropyridines and evaluated their antimicrobial activity. The minimum inhibitory concentration (MIC) was determined by microdilution technique in Mueller Hinton broth. The MICs were recorded after 24 hours of incubation at 37°C. These results showed that these compounds exhibited significant to moderate activities against both Gram-(+) and Gram-(−) organisms.

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