Diastereoselective synthesis of chiral 3-substituted isoindolinones via rhodium(III)-catalyzed oxidative C-H olefination/annulation

2021 ◽  
Author(s):  
Xue-Hong Li ◽  
Jun-Fang Gong ◽  
Mao-Ping Song
Keyword(s):  
Stereoselective Synthesis ◽  
New Method ◽  
Diastereoselective Synthesis ◽  
Acrylic Esters

A new method for the direct and stereoselective synthesis of 3-substituted isoindolinones via Rh(III)-catalyzed chiral N-sulfinyl amide directed asymmetric [4+1] annulation of benzamides with acrylic esters is developed. The reaction...

A NEW METHOD FOR THE STEREOSELECTIVE SYNTHESIS OF NUCLEOSIDES FROM ACYCLIC EPOXY ALDEHYDES

1984 ◽  
Vol 13 (7) ◽  
pp. 1093-1096 ◽  
Author(s):  
Tetsuo Miwa ◽  
Koichi Narasaka ◽  
Teruaki Mukaiyama
Keyword(s):  
Stereoselective Synthesis ◽  
New Method

Stereoselective synthesis of O-tosyl azabicyclic derivatives via aza Prins reaction of endocyclic N-acyliminium ions: application to the total synthesis of (±)-epi-indolizidine 167B and 209D

2014 ◽  
Vol 12 (36) ◽  
pp. 7026-7035 ◽  
Author(s):  
Anil K. Saikia ◽  
Kiran Indukuri ◽  
Jagadish Das
Keyword(s):  
Total Synthesis ◽  
Stereoselective Synthesis ◽  
Cyclization Reaction ◽  
Diastereoselective Synthesis ◽  
Prins Reaction ◽  
Prins Cyclization ◽  
Acyliminium Ions

A diastereoselective synthesis of 4-O-tosyl piperidine containing azabicyclic derivatives has been established via Prins cyclization reaction. This protocol has been applied for the total synthesis of (±)-epi-indolizidine 167B and 209D.

Diastereoselective Synthesis of Morpholine Derivatives from Grignard Reagents and N-Sulfinyl Imines

Synlett ◽  
2021 ◽  
Author(s):  
Eric P. A. Talbot ◽  
Joseph M. Bateman ◽  
Diana Chan ◽  
Mustafa Moroglu ◽  
Benjamin Rahemtulla
Keyword(s):  
Grignard Reagent ◽  
Stereoselective Synthesis ◽  
Grignard Reagents ◽  
Diastereoselective Synthesis ◽  
Step Process ◽  
Diastereoselective Addition ◽  
Morpholine Derivatives

The stereoselective synthesis of C3-substituted morpholine derivatives has been achieved through a two-step process involving diastereoselective addition of a Grignard reagent to a sulfinyl imine, followed by cyclization.

A new method for preparation of 3,6-dihydro-2H-1,3-oxazines and explorations of their use in stereoselective synthesis of 1,3-amino alcohol derivatives

Tetrahedron ◽  
1996 ◽  
Vol 52 (9) ◽  
pp. 3135-3152 ◽  
Author(s):  
John P. Cherkauskas ◽  
Andrew M. Klos ◽  
Robert M. Borzilleri ◽  
Joseph Sisko ◽  
Steven M. Weinreb ◽  
...  
Keyword(s):  
Amino Alcohol ◽  
Stereoselective Synthesis ◽  
New Method

A stereoselective synthesis of digitoxin. On cardioactive steroids. XIII

1984 ◽  
Vol 62 (7) ◽  
pp. 1403-1405 ◽  
Author(s):  
Thomas Y. R. Tsai ◽  
Haolun Jin ◽  
Karel Wiesner
Keyword(s):  
Stereoselective Synthesis ◽  
New Method ◽  
Cardioactive Steroids ◽  
Acid Catalyzed

The first highly stereoselective synthesis of digitoxin is described. The furyl derivative of digitoxigenin was coupled with one unit of digitoxose using our previously described acid catalyzed method. For the second and third glycosylation a new method involving ethyl thioglycosides and 1,3-participation by a p-methoxy benzoate group was developed. As the final step after deprotection of the triglycoside, the 17-furyl group in the steroid aglycone was converted to a butenolide by our oxidative method.

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