α-Tocopherol-anchored gemini lipids with delocalizable cationic head groups: Effect of spacer length on DNA compaction and transfection properties

2021 ◽  
Author(s):  
Mallikarjun Gosangi ◽  
Venkatesh Ravula ◽  
Hithavani Rapaka ◽  
Srilakshmi V Patri
Keyword(s):  
Gene Delivery ◽  
Cationic Lipids ◽  
Spacer Length ◽  
Dna Compaction ◽  
Structure Activity ◽  
Head Groups ◽  
Efficient Gene ◽  
Delivery Vehicles ◽  
Systematic Structure

Understanding the role of structural units in cationic lipids used for gene delivery is essential in designing efficient gene delivery vehicles. Herein we report a systematic structure-activity investigation on the...

Cyclen-based cationic lipids with double hydrophobic tails for efficient gene delivery

2014 ◽  
Vol 2 (10) ◽  
pp. 1460-1470 ◽  
Author(s):  
Hai-Jiao Wang ◽  
Yan-Hong Liu ◽  
Ji Zhang ◽  
Yang Zhang ◽  
Yan Xia ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Gene Transfection ◽  
Structure Activity Relationship ◽  
Cationic Lipids ◽  
Activity Relationship ◽  
Structure Activity ◽  
Efficient Gene ◽  
Relationship Of

The gene transfection abilities and structure–activity relationship of newly designed cationic lipids were studied in detail.

scholarly journals Cyclen-Based Cationic Lipids for Highly Efficient Gene Delivery towards Tumor Cells

PLoS ONE ◽  
2011 ◽  
Vol 6 (8) ◽  
pp. e23134 ◽  
Author(s):  
Qing-Dong Huang ◽  
Guo-Xing Zhong ◽  
Yang Zhang ◽  
Jiang Ren ◽  
Yun Fu ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Tumor Cells ◽  
Cationic Lipids ◽  
Highly Efficient ◽  
Efficient Gene

scholarly journals Cationic lipids with a cyclen headgroup: synthesis and structure–activity relationship studies as non-viral gene vectors

RSC Advances ◽  
2017 ◽  
Vol 7 (30) ◽  
pp. 18681-18689 ◽  
Author(s):  
De-Chun Chang ◽  
Yi-Mei Zhang ◽  
Ji Zhang ◽  
Yan-Hong Liu ◽  
Xiao-Qi Yu
Keyword(s):  
Gene Delivery ◽  
Structure Activity Relationship ◽  
Cationic Lipids ◽  
Activity Relationship ◽  
Viral Gene ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Gene Delivery Vectors ◽  
Gene Vectors ◽  
Viral Gene Delivery

The structure–activity relationships of cyclen-based cationic lipids as non-viral gene delivery vectors were studied and clarified.

scholarly journals Ionic liquids with thioether motifs as synthetic cationic lipids for gene delivery

2017 ◽  
Vol 53 (59) ◽  
pp. 8328-8331 ◽  
Author(s):  
Jamie C. Gaitor ◽  
Lauren M. Paul ◽  
Melissa M. Reardon ◽  
Taha Hmissa ◽  
Samuel Minkowicz ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Gene Delivery ◽  
Click Chemistry ◽  
Gene Transfection ◽  
Cationic Lipids ◽  
Efficient Gene

Novel lipidic ionic liquids with imidazolium headgroups (red), thioether linkers (black), and two hydrophobic tails (blue) as efficient gene transfection vectors, synthesized via thiol–yne click chemistry.

Cyclen-based cationic lipids containing a pH-sensitive moiety as gene delivery vectors

2015 ◽  
Vol 13 (2) ◽  
pp. 620-630 ◽  
Author(s):  
Zheng Huang ◽  
Yan-Hong Liu ◽  
Yi-Mei Zhang ◽  
Ji Zhang ◽  
Qiang Liu ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Structure Activity Relationship ◽  
Ph Sensitive ◽  
Cationic Lipids ◽  
Activity Relationship ◽  
Structure Activity ◽  
Gene Delivery Vectors

Imidazole-functionalized cationic lipids with a cyclen headgroup were synthesized, and the structure–activity relationship in gene delivery mediated by these lipids was discussed.

scholarly journals An organometallic structure-activity relationship study reveals the essential role of a Re(CO)3moiety in the activity against gram-positive pathogens including MRSA

2015 ◽  
Vol 6 (1) ◽  
pp. 214-224 ◽  
Author(s):  
Malay Patra ◽  
Michaela Wenzel ◽  
Pascal Prochnow ◽  
Vanessa Pierroz ◽  
Gilles Gasser ◽  
...  
Keyword(s):  
Essential Role ◽  
Antibacterial Agents ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Gram Positive ◽  
Structural Class ◽  
Structure Activity ◽  
Systematic Structure ◽  
Relationship Study

A systematic structure activity relationship reveals the contribution of individual organometallic moieties to the potency of a new structural class of hetero-trimetallic antibacterial agents.

scholarly journals Novel Cholesterol-Based Cationic Lipids as Transfecting Agents of DNA for Efficient Gene Delivery

2015 ◽  
Vol 16 (12) ◽  
pp. 5666-5681 ◽  
Author(s):  
Jia Ju ◽  
Meng-Lei Huan ◽  
Ning Wan ◽  
Hai Qiu ◽  
Si-Yuan Zhou ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Cationic Lipids ◽  
Efficient Gene

Charge-switching amino acids-based cationic lipids for efficient gene delivery

2015 ◽  
Vol 25 (24) ◽  
pp. 5677-5681 ◽  
Author(s):  
Li-Ting Zheng ◽  
Wen-Jing Yi ◽  
Qiang Liu ◽  
Rong-Chuan Su ◽  
Zhi-Gang Zhao
Keyword(s):  
Amino Acids ◽  
Gene Delivery ◽  
Cationic Lipids ◽  
Efficient Gene

Tuning the Self-Assembling of Pyridinium Cationic Lipids for Efficient Gene Delivery into Neuronal Cells

2013 ◽  
Vol 14 (8) ◽  
pp. 2750-2764 ◽  
Author(s):  
Sushma Savarala ◽  
Eugen Brailoiu ◽  
Stephanie L. Wunder ◽  
Marc A. Ilies
Keyword(s):  
Gene Delivery ◽  
Neuronal Cells ◽  
Cationic Lipids ◽  
The Self ◽  
Self Assembling ◽  
Efficient Gene
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