Generalizable synthesis of bioresponsive near-infrared fluorescent probes: sulfonated heptamethine cyanine prototype for imaging cell hypoxia

2021 ◽  
Author(s):  
Kirk M. Atkinson ◽  
Janeala J. Morsby ◽  
Sai Shradha Reddy Kommidi ◽  
Bradley D. Smith
Keyword(s):  
Fluorescent Probes ◽  
Near Infrared ◽  
Molecular Probe ◽  
Synthetic Method ◽  
Microscopic Imaging ◽  
Turn On ◽  
Cell Hypoxia

A new synthetic method produces a bioresponsive near-infrared molecular probe that undergoes “turn-on” fluorescence for microscopic imaging of hypoxia.

Turn-on visible and ratiometric near-infrared fluorescent probes for distinction endogenous esterases and chymotrypsins in live cells

2020 ◽  
Vol 306 ◽  
pp. 127567 ◽  
Author(s):  
Jiemin Wang ◽  
Zhidong Teng ◽  
Ting Cao ◽  
Jing Qian ◽  
Lei Zheng ◽  
...  
Keyword(s):  
Fluorescent Probes ◽  
Near Infrared ◽  
Live Cells ◽  
Turn On

scholarly journals Design of Turn‐On Near‐Infrared Fluorescent Probes for Highly Sensitive and Selective Monitoring of Biopolymers

2020 ◽  
Vol 59 (22) ◽  
pp. 8440-8444 ◽  
Author(s):  
Gerard T. Ducharme ◽  
Zane LaCasse ◽  
Tanya Sheth ◽  
Irina V. Nesterova ◽  
Evgueni E. Nesterov
Keyword(s):  
Fluorescent Probes ◽  
Near Infrared ◽  
Turn On ◽  
Highly Sensitive ◽  
Selective Monitoring

scholarly journals Near-infrared turn-on fluorescent probe for discriminative detection of Cys and application in in vivo imaging

RSC Advances ◽  
2019 ◽  
Vol 9 (71) ◽  
pp. 41431-41437 ◽  
Author(s):  
Shaolong Qi ◽  
Lubao Zhu ◽  
Xinyu Wang ◽  
Jianshi Du ◽  
Qingbiao Yang ◽  
...  
Keyword(s):  
Fluorescent Probes ◽  
Biological Samples ◽  
In Vivo Imaging ◽  
Near Infrared ◽  
Signal To Noise Ratio ◽  
High Signal ◽  
Biological Detection ◽  
Signal To Noise ◽  
Turn On

Near-infrared (NIR) fluorescent probes are widely employed in biological detection because of their lower damage to biological samples, low background interference, and high signal-to-noise ratio.

Gold Nanocluster-Based Fluorescent Probes for Near-Infrared and Turn-On Sensing of Glutathione in Living Cells

Langmuir ◽  
2012 ◽  
Vol 28 (8) ◽  
pp. 3945-3951 ◽  
Author(s):  
Dahui Tian ◽  
Zhangsheng Qian ◽  
Yunsheng Xia ◽  
Changqing Zhu
Keyword(s):  
Fluorescent Probes ◽  
Near Infrared ◽  
Living Cells ◽  
Gold Nanocluster ◽  
Turn On

Highly selective turn-on detection of (strept)avidin based on self-assembled near-infrared fluorescent probes

RSC Advances ◽  
2015 ◽  
Vol 5 (48) ◽  
pp. 38571-38576 ◽  
Author(s):  
Qingyuan He ◽  
Xiaopeng Fan ◽  
Shiguo Sun ◽  
Hongjuan Li ◽  
Yuxin Pei ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Fluorescent Probe ◽  
Fluorescent Probes ◽  
Near Infrared ◽  
Fluorescent Dye ◽  
Turn On ◽  
Self Assembled

A small molecular fluorescent dye (SQ-Biotin) which can self-assemble into a non-fluorescent probe in aqueous solution for near infrared turn-on detection of avidin protein.

Development of green to near-infrared turn-on fluorescent probes for the multicolour imaging of nitroxyl in living systems

2016 ◽  
Vol 4 (7) ◽  
pp. 1263-1269 ◽  
Author(s):  
Baoli Dong ◽  
Kaibo Zheng ◽  
Yonghe Tang ◽  
Weiying Lin
Keyword(s):  
Fluorescent Probes ◽  
Near Infrared ◽  
Living Systems ◽  
Turn On

The green to near-infrared turn-on fluorescent probes were developed for the multicolour imaging of nitroxyl in living systems.

scholarly journals Design of Turn‐On Near‐Infrared Fluorescent Probes for Highly Sensitive and Selective Monitoring of Biopolymers

2020 ◽  
Vol 132 (22) ◽  
pp. 8518-8522
Author(s):  
Gerard T. Ducharme ◽  
Zane LaCasse ◽  
Tanya Sheth ◽  
Irina V. Nesterova ◽  
Evgueni E. Nesterov
Keyword(s):  
Fluorescent Probes ◽  
Near Infrared ◽  
Turn On ◽  
Highly Sensitive ◽  
Selective Monitoring

scholarly journals Facilitation of molecular motion to develop turn-on photoacoustic bioprobe for detecting nitric oxide in encephalitis

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Ji Qi ◽  
Leyan Feng ◽  
Xiaoyan Zhang ◽  
Haoke Zhang ◽  
Liwen Huang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Near Infrared ◽  
Molecular Probe ◽  
Energy Transformation ◽  
Spatiotemporal Resolution ◽  
Turn On ◽  
Specificity And Sensitivity ◽  
Intramolecular Motion ◽  
Transformation Processes

AbstractNitric oxide (NO) is an important signaling molecule overexpressed in many diseases, thus the development of NO-activatable probes is of vital significance for monitoring related diseases. However, sensitive photoacoustic (PA) probes for detecting NO-associated complicated diseases (e.g., encephalitis), have yet to be developed. Herein, we report a NO-activated PA probe for in vivo detection of encephalitis by tuning the molecular geometry and energy transformation processes. A strong donor-acceptor structure with increased conjugation can be obtained after NO treatment, along with the active intramolecular motion, significantly boosting “turn-on” near-infrared PA property. The molecular probe exhibits high specificity and sensitivity towards NO over interfering reactive species. The probe is capable of detecting and differentiating encephalitis in different severities with high spatiotemporal resolution. This work will inspire more insights into the development of high-performing activatable PA probes for advanced diagnosis by making full use of intramolecular motion and energy transformation processes.

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