Synthesis and characterization of mono S-lipidated peptide hydrogels: a platform for the preparation of reactive oxygen species responsive materials

2021 ◽  
Author(s):  
Aakanksha Rani ◽  
Luis Manuel M De Leon Rodriguez ◽  
Iman Kavianinia ◽  
Duncan James McGillivray ◽  
David Edward Williams ◽  
...  
Keyword(s):  
The Self ◽  
Synthesis And Characterization ◽  
Oxygen Species ◽  
Responsive Materials ◽  
Ene Reaction ◽  
Self Assembling ◽  
N Terminus ◽  
Lipidated Peptides ◽  
Peptide Hydrogels

In this work we report the synthesis of mono lipidated peptides containing a 3-mercaptopropionate linker in the N-terminus by means of a photoinitiated thiol-ene reaction (S-lipidation). We evaluate the self-assembling...

Monitoring the Early Stage Self-Assembly of Enzyme-Assisted Peptide Hydrogels

2013 ◽  
Vol 66 (5) ◽  
pp. 572 ◽  
Author(s):  
Richard J. Williams ◽  
James Gardiner ◽  
Anders B. Sorensen ◽  
Silvia Marchesan ◽  
Roger J. Mulder ◽  
...  
Keyword(s):  
1H Nmr ◽  
Self Assembly ◽  
Early Stage ◽  
The Self ◽  
Spectroscopic Techniques ◽  
Subsequent Formation ◽  
Self Assembling ◽  
Hydrogel Formation ◽  
Assembly Kinetics ◽  
Peptide Hydrogels

The early stages of the self-assembly of peptide hydrogels largely determine their final material properties. Here we discuss experimental methodologies for monitoring the self-assembly kinetics which underpin peptide hydrogel formation. The early stage assembly of an enzyme-catalysed Fmoc-trileucine based self-assembled hydrogel was examined using spectroscopic techniques (circular dichroism, CD, and solution NMR) as well as chromatographic (HPLC) and mechanical (rheology) techniques. Optimal conditions for enzyme-assisted hydrogel formation were identified and the kinetics examined. A lag time associated with the formation and accumulation of the self-assembling peptide monomer was observed and a minimum hydrogelator concentration required for gelation was identified. Subsequent formation of well defined nano- and microscale structures lead to self-supporting hydrogels at a range of substrate and enzyme concentrations. 1H NMR monitoring of the early self-assembly process revealed trends that were well in agreement with those identified using traditional methods (i.e. HPLC, CD, rheology) demonstrating 1H NMR spectroscopy can be used to non-invasively monitor the self-assembly of peptide hydrogels without damaging or perturbing the system.

Synthesis and characterization of designed BMHP1-derived self-assembling peptides for tissue engineering applications

Nanoscale ◽  
2013 ◽  
Vol 5 (2) ◽  
pp. 704-718 ◽  
Author(s):  
Diego Silva ◽  
Antonino Natalello ◽  
Babak Sanii ◽  
Rajesh Vasita ◽  
Gloria Saracino ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Synthesis And Characterization ◽  
Engineering Applications ◽  
Self Assembling

Design and Characterization of Nanoarchitectures from Multifunctional Polyparaphenylenes

2003 ◽  
Vol 776 ◽  
Author(s):  
Renu Ravindranath ◽  
Suresh Valiyaveettil ◽  
Chinnapan Baskar ◽  
Ananda Putra ◽  
Fitri Fitrilawati ◽  
...  
Keyword(s):  
Thin Films ◽  
Conducting Polymers ◽  
Self Assembly ◽  
The Self ◽  
Morphological Properties ◽  
Synthesis And Characterization ◽  
Solution Properties ◽  
Wide Range ◽  
Modified Surfaces

AbstractConducting polymers are interesting materials due to their wide range of applications in electronics, sensing, photonics and display applications. The present paper delineates the synthesis and characterization of the three functionalized poly (p-phenylene)s (PPP) (A-C) and solution properties of the polymers. The self-assembly of the polymers were investigated on various substrates and the optical/morphological properties of thin films of these polymers were also studied. The spontaneous self assembly of the modified PPP's lead to the formation of thin films on both hydrophilic and modified surfaces.

Harnessing the self-assembly of peptides for the targeted delivery of anti-cancer agents

2020 ◽  
Vol 7 (8) ◽  
pp. 1996-2010 ◽  
Author(s):  
Stephanie J. Franks ◽  
Kate Firipis ◽  
Rita Ferreira ◽  
Katherine M. Hannan ◽  
Richard J. Williams ◽  
...  
Keyword(s):  
Self Assembly ◽  
Targeted Delivery ◽  
Drug Efficacy ◽  
The Self ◽  
Cancer Drug ◽  
Self Assembling ◽  
Anti Cancer ◽  
Therapeutic Molecules ◽  
Peptide Hydrogels

Self-assembling peptide hydrogels can effectively transport, hold and release therapeutic molecules in a spatially and temporally controlled manner and, in doing so, improve anti-cancer drug efficacy while reducing non-specific toxicity.

Synthesis and characterization of self-assembling block copolymers containing fluorine groups

2012 ◽  
Author(s):  
Rina Maeda ◽  
Michelle Chavis ◽  
Nam-Ho You ◽  
Christopher K. Ober
Keyword(s):  
Block Copolymers ◽  
Synthesis And Characterization ◽  
Self Assembling

Synthesis and Characterization of Amphiphilic PEG Based Polymers and Their Self Assembling Behavior

2015 ◽  
Vol 52 (6) ◽  
pp. 417-424 ◽  
Author(s):  
Anu Kumari ◽  
Jitendra Kumar ◽  
Najam A. Shakil ◽  
Braj B. Singh ◽  
Arthur C. Watterson
Keyword(s):  
Synthesis And Characterization ◽  
Self Assembling

Synthesis and Characterization of Self-Assembling Amphiphilic Aromatic Amide Dendrons

2006 ◽  
Vol 18 (5) ◽  
pp. 761-775
Author(s):  
Teruaki Hayakawa ◽  
Shigemasa Nakasugi ◽  
Masa-Aki Kakimoto ◽  
Masatoshi Tokita ◽  
Junji Watanabe
Keyword(s):  
Synthesis And Characterization ◽  
Self Assembling ◽  
Aromatic Amide

The Synthesis and Characterization of a Self-Assembling Amphiphilic Fullerene

1994 ◽  
Vol 59 (12) ◽  
pp. 3503-3505 ◽  
Author(s):  
Craig J. Hawker ◽  
Paul M. Saville ◽  
John W. White
Keyword(s):  
Synthesis And Characterization ◽  
Self Assembling
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