Crown Ether—Pillararenes Hybrid Macrocyclic System

2021 ◽  
Author(s):  
Zhaona Liu ◽  
Huacheng Zhang ◽  
Jie Han
Keyword(s):  
Crown Ether ◽  
Hybrid Systems ◽  
Organic Synthesis ◽  
Material Science ◽  
Planar Chirality ◽  
System P ◽  
Structural Architecture ◽  
Macrocyclic System

Combination of Nobel macrocycle—crown ether and star macrocycle—pillararenes together in organic synthesis and material science is significant to grant thus obtained hybrid systems, rigid/flexible structural architecture, induced planar chirality, negative...

Construction of N-heterocycles via Pd-mediated C–H activation/annulation strategies

2022 ◽  
Author(s):  
Mengyu Qiu ◽  
Xuegang Fu ◽  
Peng Fu ◽  
Jianhui Huang
Keyword(s):  
Natural Products ◽  
Organic Synthesis ◽  
Material Science ◽  
Medicinal Chemistry ◽  
Drug Molecules

N-heterocycles can be found in natural products and drug molecules, which are indispensable components in the area of organic synthesis, medicinal chemistry and material science. The construction of these N-containing...

The Synthesis of Amides through Direct Amination of Aldehydes with Amines

2019 ◽  
Vol 23 (8) ◽  
pp. 901-919 ◽  
Author(s):  
Yaorui Ma ◽  
Junfei Luo
Keyword(s):  
Natural Products ◽  
Organic Synthesis ◽  
Material Science ◽  
Catalyst System ◽  
Fundamental Groups ◽  
Direct Amination ◽  
Amide Bonds ◽  
The Past ◽  
Amide Synthesis ◽  
The Future

Amide bonds are amongst the most fundamental groups in organic synthesis, and they are widely found in natural products, pharmaceuticals and material science. Over the past decade, methods for the direct amination of aldehydes have received much attention as they represent atom- and step-economic routes for amide synthesis from readily available starting materials. Herein, the research advances on the direct amination of aldehydes are reviewed and categorized by the types of catalyst system. Detailed reaction scopes and mechanisms will be discussed, as well as the limitations of current procedures and the prospects for the future.

π-Complexes with planar chirality: control centres for stereoselective synthesis

1988 ◽  
Vol 326 (1592) ◽  
pp. 545-556 ◽  
Keyword(s):  
Organic Synthesis ◽  
Functional Group ◽  
Stereoselective Synthesis ◽  
Substitution Pattern ◽  
Planar Chirality ◽  
Synthesis Design ◽  
Alternative Method ◽  
Synthetic Sequence ◽  
Chirality Control

Organom etallic π-complexes are defined as the synthetic equivalents of cationic synthons for use in organic synthesis. W hen complexes of this type are employed, activation and stereocontrol effects (which arise from properties of the metal), and regiocontrol effects and functional group locations (resulting from substitution pattern), are separated from one another. The consequences of this distinction for synthesis design are discussed by using two examples, an approach for the synthesis of tridachiapyrones based on a ‘linear’ synthetic sequence, and an alternative method for double alkylations employing an ‘iterative’ strategy. Access to resolved compounds for enantiom er synthesis is described.

scholarly journals Role of Click Chemistry in Organic Synthesis

2021 ◽  
Author(s):  
Ayushi Sethiya ◽  
Nusrat Sahiba ◽  
Shikha Agarwal
Keyword(s):  
Click Chemistry ◽  
Organic Synthesis ◽  
Material Science ◽  
Diels Alder ◽  
Organic Reactions ◽  
Ene Reactions ◽  
Click Reactions ◽  
Ring Opening Reactions ◽  
Nucleophilic Ring Opening

Click chemistry involves highly efficient organic reactions of two or more highly functionalized chemical entities under eco-benign conditions for the synthesis of different heterocycles. Several organic reactions such as nucleophilic ring-opening reactions, cyclo-additions, nucleophilic addition reactions, thiol-ene reactions, Diels Alder reactions, etc. are included in click reactions. These reactions have very important features i.e. high functional group tolerance, formation of a single product, high atom economy, high yielding, no need for column purification, etc. It also possesses several applications in drug discovery, supramolecular chemistry, material science, nanotechnology, etc. Being highly significant and valuable, we have elaborated on several aspects of click reactions in organic synthesis in this chapter. Recent advancements in the field of organic synthesis using click chemistry approach have been deliberated by citing last five years articles.

scholarly journals A Review on Green Synthesis and Biological Activities of Nitrogen and Oxygen Containing Heterocycles

2021 ◽  
Author(s):  
Susheel Gulati ◽  
Rajvir Singh ◽  
Suman Sangwan
Keyword(s):  
Analytical Chemistry ◽  
Green Chemistry ◽  
Organic Synthesis ◽  
Material Science ◽  
Biological Activities ◽  
Review Article ◽  
Synthetic Methods ◽  
Mild Conditions ◽  
Environmental Friendly ◽  
Benign Solvents

Heterocycles are unique precursors for the synthesis of various pharmaceuticals and agrochemicals particularly those possessing N- or O- moieties. The development of methods to prepare heterocycles is of great importance in synthesis of organic compounds, especially the heterocycles which can be found in natural products. The synthesis of nitrogen and oxygen containing heterocycles viz. coumarins, dihydropyrimidinones, imidazoles, isoxazoles and benzimidazoles represented an attractive and demanding work for chemists as these nucleus has found extensive applications in several fields such as material science, analytical chemistry and most importantly in medicinal chemistry. Organic synthesis has been attracted towards the development of new environmental friendly procedures to achieve the goals of green chemistry. The fundamental aspects of green chemistry are use of biocatalysts and environmental benign solvents under mild conditions. The present review article summarized the green synthetic methods and biological activities of nitrogen and oxygen containing heterocycles.

scholarly journals Mechanochemistry: A Green Approach in the Preparation of Pharmaceutical Cocrystals

Pharmaceutics ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 790
Author(s):  
Mizraín Solares-Briones ◽  
Guadalupe Coyote-Dotor ◽  
José C. Páez-Franco ◽  
Miriam R. Zermeño-Ortega ◽  
Carmen Myriam de la O Contreras ◽  
...  
Keyword(s):  
Metal Complexes ◽  
Classical Solution ◽  
Organic Synthesis ◽  
Mechanochemical Synthesis ◽  
Material Science ◽  
Pharmaceutical Cocrystals ◽  
Green Approach ◽  
Solvent Free Conditions ◽  
Scientific Papers ◽  
Molecular Compounds

Mechanochemistry is considered an alternative attractive greener approach to prepare diverse molecular compounds and has become an important synthetic tool in different fields (e.g., physics, chemistry, and material science) since is considered an ecofriendly procedure that can be carried out under solvent free conditions or in the presence of minimal quantities of solvent (catalytic amounts). Being able to substitute, in many cases, classical solution reactions often requiring significant amounts of solvents. These sustainable methods have had an enormous impact on a great variety of chemistry fields, including catalysis, organic synthesis, metal complexes formation, preparation of multicomponent pharmaceutical solid forms, etc. In this sense, we are interested in highlighting the advantages of mechanochemical methods on the obtaining of pharmaceutical cocrystals. Hence, in this review, we describe and discuss the relevance of mechanochemical procedures in the formation of multicomponent solid forms focusing on pharmaceutical cocrystals. Additionally, at the end of this paper, we collect a chronological survey of the most representative scientific papers reporting the mechanochemical synthesis of cocrystals.

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