Divergent Chiron Approach for the First Total Synthesis of (+)-Pseudonocardide A, (+)-Pseudonocardide C and an epimer of ent-Pseudonocardide D

2021 ◽  
Author(s):  
Kapil Sharma ◽  
Naresh Surineni ◽  
Sayani Das ◽  
Shivajirao L. Gholap
Keyword(s):  
Total Synthesis ◽  
Salient Features

A concise and divergent chiron approach for the first total synthesis of (+)-Pseudonocardide A, (+)-Pseudonocardide C and an epimer of ent-Pseudonocardide D is reported starting from D-ribose. The salient features...

Studies towards the Total Synthesis of Kadcotrione B

Synthesis ◽  
2019 ◽  
Vol 52 (05) ◽  
pp. 735-743
Author(s):  
Julakanti Satyanarayana Reddy ◽  
Marri Gangababu ◽  
Patel Manimala ◽  
Aluru Rammohan ◽  
Jillu Singh Yadav
Keyword(s):  
Total Synthesis ◽  
Michael Addition ◽  
Aldol Condensation ◽  
Aldol Reaction ◽  
Side Chain ◽  
Wacker Oxidation ◽  
Efficient Approach ◽  
Salient Features ◽  
Robinson Annulation

A convergent and efficient approach towards the total synthesis of Kadcotrione B is described. For this purpose, the syntheses of two fragments, 6/6/5-fused tricyclic ring and C-9 side chain, were accomplished. The salient features of these syntheses are the utilization of aldol condensation, Evans aldol reaction, Horner–Wadsworth–Emmons olefination, Michael addition, Robinson annulation, and Wacker oxidation.

scholarly journals Total Synthesis and Structural Reassignment of Laingolide A

Marine Drugs ◽  
2021 ◽  
Vol 19 (5) ◽  
pp. 247
Author(s):  
Fusong Wu ◽  
Tao Zhang ◽  
Jie Yu ◽  
Yian Guo ◽  
Tao Ye
Keyword(s):  
Total Synthesis ◽  
Natural Product ◽  
Asymmetric Total Synthesis ◽  
Type Coupling ◽  
Salient Features ◽  
Unambiguous Assignment

The asymmetric total synthesis of four diastereomers of laingolide A was achieved, which led to the unambiguous assignment of the stereochemistry of the natural product. The salient features of the convergent, fully stereocontrolled approach were a copper-catalysed stereospecific Kumada-type coupling, a Julia-Kocienski olefination and an RCM/alkene migration sequence to access the desired macrocyclic enamide.

Total synthesis of Δ9(12)-capnellene-8α,10α-diol

1982 ◽  
Vol 23 (52) ◽  
pp. 5471-5474
Author(s):  
G Pattenden
Keyword(s):  
Total Synthesis

Total synthesis of melleumins A and B and their analogs: Determination of stereochemistry and Wnt signal inhibitory activity

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
M Ishibashi ◽  
S Hanazawa ◽  
Y Uchino ◽  
X Li ◽  
MA Arai
Keyword(s):  
Total Synthesis ◽  
Inhibitory Activity ◽  
Wnt Signal

Progress Toward The Total Synthesis Of The Marine Natural Product Karlotoxin 5

Planta Medica ◽  
2013 ◽  
Vol 79 (10) ◽  
Author(s):  
M Albadry ◽  
Y Zou ◽  
Y Takahashi ◽  
A Waters ◽  
M Hossein ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Natural Product ◽  
Marine Natural Product

Formal Total Synthesis of Clausenamide

Synlett ◽  
1991 ◽  
Vol 1991 (04) ◽  
pp. 343-344
Author(s):  
Takayuki Yakura ◽  
Yukiko Matsumura ◽  
Masazumi Ikeda
Keyword(s):  
Total Synthesis
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