Engineered extracellular vesicles encapsulated Bryostatin-1 as therapy for neuroinflammation

Nanoscale ◽  
2022 ◽  
Author(s):  
Wen-Cheng Wu ◽  
Jing Tian ◽  
Dan Xiao ◽  
Yu-Xin Guo ◽  
Yun Xiao ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Drug Delivery ◽  
Central Nervous System ◽  
Nervous System ◽  
Extracellular Vesicles ◽  
Effective Drug ◽  
Great Promise ◽  
Bryostatin 1 ◽  
Cns Lesions

Targeted and effective drug delivery to central nervous system (CNS) lesions is a major challenge in the treatment of multiple sclerosis (MS). Extracellular vesicles (EVs) have great promise as a...

Nanomedicine Applications in Treatment of Primary Central Nervous System Lymphoma: Current State of the Art

2021 ◽  
Vol 17 (8) ◽  
pp. 1459-1485
Author(s):  
Mengyao Wang ◽  
Ying Qu ◽  
Danrong Hu ◽  
Ting Niu ◽  
Zhiyong Qian
Keyword(s):  
Drug Delivery ◽  
Central Nervous System ◽  
Nervous System ◽  
Drug Delivery Systems ◽  
Central Nervous System Lymphoma ◽  
Delivery Systems ◽  
Brain Diseases ◽  
Current Status ◽  
Great Promise ◽  
Antitumor Effects

Primary central nervous system lymphoma (PCNSL) is a rare but highly aggressive subtype of extra nodal non-Hodgkin lymphoma (NHL), which is confined in the central nervous system (CNS). Despite recent advancements in treatment options, the overall prognosis of PCNSL remains poor. Among many unfavorable factors affecting efficacy, inadequate drug delivery into the CNS is still the thorniest challenge. Blood-brain barrier (BBB) constitutes a significant impediment, restricting entry of most therapeutics to the brain. Nanotechnology has offered great promise for brain diseases, as various nano-based drug delivery systems (NDDSs) have been developed for delivery of theranostic agents in to the CNS. These drug delivery systems possess significant advantages, including good feasibility, reliable safety profile, excellent BBB penetration and potent antitumor effects. As for treatment of PCNSL, numerous well-developed BBB-crossing nano-based strategies can be applied with proper modifications and improvements. Some exquisitely designed NDDSs specific for PCNSL have shown great potential. In this review, we provide a summary on current status of diagnosis and treatment of PCNSL, followed by an overview of BBB-crossing strategies applied in management of PCNSL, both novel and wellestablished. Finally, challenges and future perspectives in this field are also discussed.

Nanoparticle-mediated Drug Delivery Systems (DDS) in the Central Nervous System

2016 ◽  
Vol 21 (3) ◽  
pp. 272-283 ◽  
Author(s):  
Guilong Zhang ◽  
Lukui Chen ◽  
Xiaoyuan Guo ◽  
Ahsan Khan ◽  
Yuchun Gu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Central Nervous System ◽  
Nervous System ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
The Central Nervous System

Multiple Sclerosis Is Rare in Epstein–Barr Virus–Seronegative Children with Central Nervous System Inflammatory Demyelination

2021 ◽  
Author(s):  
Bardia Nourbakhsh ◽  
Christian Cordano ◽  
Carlo Asteggiano ◽  
Klemens Ruprecht ◽  
Carolin Otto ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Central Nervous System ◽  
Nervous System ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Epstein Barr
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