Near-Infrared Light-Responsive Hybrid Hydrogels for the Synergistic Chemo-Photothermal Therapy of Oral Cancer

Nanoscale ◽  
2021 ◽  
Author(s):  
Yongzhi Wu ◽  
Fangman Chen ◽  
Nengwen Huang ◽  
Jinjin Li ◽  
Chenzhou Wu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cancer ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Light Stimulus ◽  
Infrared Light ◽  
Promising Strategy ◽  
Hybrid Hydrogels ◽  
Stimulus Responsive ◽  
Multifunctional Platform

Light-stimulus-responsive therapies have been recognized as a promising strategy for the efficient and safe treatment of oral squamous cell carcinoma (OSCC). Hydrogels have emerged as a promising multifunctional platform combining...

Near-Infrared Light-Stimulus-Responsive Film as a Sacrificial Layer for the Preparation of Free-Standing Films

Langmuir ◽  
2016 ◽  
Vol 32 (14) ◽  
pp. 3393-3399 ◽  
Author(s):  
Chunyang Bao ◽  
Benhua Ma ◽  
Jiale Liu ◽  
Zhennan Wu ◽  
Hao Zhang ◽  
...  
Keyword(s):  
Near Infrared ◽  
Light Stimulus ◽  
Sacrificial Layer ◽  
Infrared Light ◽  
Free Standing ◽  
Near Infrared Light ◽  
Stimulus Responsive

scholarly journals Boosting Chemodynamic Therapy by the Synergistic Effect of Co-Catalyze and Photothermal Effect Triggered by the Second Near-Infrared Light

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Songtao Zhang ◽  
Longhai Jin ◽  
Jianhua Liu ◽  
Yang Liu ◽  
Tianqi Zhang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Bovine Serum Albumin ◽  
Synergistic Effect ◽  
Bovine Serum ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Infrared Light ◽  
Photothermal Effect ◽  
Reaction Efficiency

AbstractIn spite of the tumor microenvironments responsive cancer therapy based on Fenton reaction (i.e., chemodynamic therapy, CDT) has been attracted more attentions in recent years, the limited Fenton reaction efficiency is the important obstacle to further application in clinic. Herein, we synthesized novel FeO/MoS2 nanocomposites modified by bovine serum albumin (FeO/MoS2-BSA) with boosted Fenton reaction efficiency by the synergistic effect of co-catalyze and photothermal effect of MoS2 nanosheets triggered by the second near-infrared (NIR II) light. In the tumor microenvironments, the MoS2 nanosheets not only can accelerate the conversion of Fe3+ ions to Fe2+ ions by Mo4+ ions on their surface to improve Fenton reaction efficiency, but also endow FeO/MoS2-BSA with good photothermal performances for photothermal-enhanced CDT and photothermal therapy (PTT). Consequently, benefiting from the synergetic-enhanced CDT/PTT, the tumors are eradicated completely in vivo. This work provides innovative synergistic strategy for constructing nanocomposites for highly efficient CDT.

scholarly journals Photothermal Therapy Using Gold Nanorods and Near-Infrared Light in a Murine Melanoma Model Increases Survival and Decreases Tumor Volume

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Mary K. Popp ◽  
Imane Oubou ◽  
Colin Shepherd ◽  
Zachary Nager ◽  
Courtney Anderson ◽  
...  
Keyword(s):  
Light Source ◽  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Tumor Volume ◽  
Infrared Light ◽  
Led Light ◽  
Murine Melanoma ◽  
Nir Light ◽  
Melanoma Model

Photothermal therapy (PTT) treatments have shown strong potential in treating tumors through their ability to target destructive heat preferentially to tumor regions. In this paper we demonstrate that PTT in a murine melanoma model using gold nanorods (GNRs) and near-infrared (NIR) light decreases tumor volume and increases animal survival to an extent that is comparable to the current generation of melanoma drugs. GNRs, in particular, have shown a strong ability to reach ablative temperatures quickly in tumors when exposed to NIR light. The current research tests the efficacy of GNRs PTT in a difficult and fast growing murine melanoma model using a NIR light-emitting diode (LED) light source. LED light sources in the NIR spectrum could provide a safer and more practical approach to photothermal therapy than lasers. We also show that the LED light source can effectively and quickly heatin vitroandin vivomodels to ablative temperatures when combined with GNRs. We anticipate that this approach could have significant implications for human cancer therapy.

The polyvinylpyrrolidone functionalized rGO/Bi2S3nanocomposite as a near-infrared light-responsive nanovehicle for chemo-photothermal therapy of cancer

Nanoscale ◽  
2016 ◽  
Vol 8 (22) ◽  
pp. 11531-11542 ◽  
Author(s):  
Ruixia Dou ◽  
Zhen Du ◽  
Tao Bao ◽  
Xinghua Dong ◽  
Xiaopeng Zheng ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Near Infrared ◽  
Infrared Light ◽  
Near Infrared Light

scholarly journals Polypeptide-Based Gold Nanoshells for Photothermal Therapy

2016 ◽  
Vol 22 (1) ◽  
pp. 18-25 ◽  
Author(s):  
Kristine M. Mayle ◽  
Kathryn R. Dern ◽  
Vincent K. Wong ◽  
Shijun Sung ◽  
Ke Ding ◽  
...  
Keyword(s):  
Heat Generation ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Gold Nanoshells ◽  
Core Material ◽  
Infrared Light ◽  
Great Promise ◽  
Laser Exposure ◽  
Enhanced Absorption ◽  
Block Copolypeptide

Targeted killing of cancer cells by engineered nanoparticles holds great promise for noninvasive photothermal therapy applications. We present the design and generation of a novel class of gold nanoshells with cores composed of self-assembled block copolypeptide vesicles with photothermal properties. Specifically, poly(L-lysine)60- block-poly(L-leucine)20 (K60L20) block copolypeptide vesicles coated with a thin layer of gold demonstrate enhanced absorption of light due to surface plasmon resonance (SPR) in the near-infrared range. We show that the polypeptide-based K60L20 gold nanoshells have low toxicity in the absence of laser exposure, significant heat generation upon exposure to near-infrared light, and, as a result, localized cytotoxicity within the region of laser irradiation in vitro. To gain a better understanding of our gold nanoshells in the context of photothermal therapy, we developed a comprehensive mathematical model for heat transfer and experimentally validated this model by predicting the temperature as a function of time and position in our experimental setup. This model can be used to predict which parameters of our gold nanoshells can be manipulated to improve heat generation for tumor destruction. To our knowledge, our results represent the first ever use of block copolypeptide vesicles as the core material of gold nanoshells.

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