Pseudo-single domain colloidal superparamagnetic nanoparticles designed at a physiologically tolerable AC magnetic field for clinically safe hyperthermia

Nanoscale ◽  
2021 ◽  
Author(s):  
Ji-wook Kim ◽  
Dan Heo ◽  
Jie Wang ◽  
Hyung-sub Kim ◽  
Satoshi Ota ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Magnetic Hyperthermia ◽  
Superparamagnetic Nanoparticles ◽  
Single Domain ◽  
Ac Magnetic Field ◽  
Highly Efficient

Pseudo-single domain superparamagnetic nanoparticles demonstrate highly efficient magnetic hyperthermia performance at the biologically safe and physiologically tolerable range of AC magnetic field (fappl < 120 kHz and Happl < 190 Oe).

scholarly journals Enhanced Cancer Cell (HeLa) Killing Efficacy of Mixed Αlpha and Gamma Iron Oxide Superparamagnetic Nanoparticles under Combined AC (Alternating Current) Magnetic-Field and Photoexcitation

1970 ◽  
Vol 12 (4) ◽  
Author(s):  
Md. Shariful Islam, Yoshihumi Kusumoto, Md. Abdulla Al-Mamun And Yuji Horie
Keyword(s):  
Magnetic Field ◽  
Iron Oxide ◽  
Hela Cells ◽  
Room Temperature ◽  
Heat Dissipation ◽  
Alternating Current ◽  
Superparamagnetic Nanoparticles ◽  
Gamma Iron ◽  
Ac Magnetic Field ◽  
Current Magnetic Field

We synthesized mixed α and γ-Fe2O3 nanoparticles and investigated their toxic effects against HeLa cells under induced AC (alternating current) magnetic-fields and photoexcited conditions at room temperature. The findings revealed that the cell-killing percentage was increased with increasing dose for all types of treatments. Finally, 99% cancer cells were destructed at 1.2 mL dose when exposed to combined AC magnetic-field and photoexcited conditions (T3) whereas 89 and 83 % of HeLa cells were killed under only AC magnetic-field induced (T1) or only photoexcited (T2) condition at the same dose.ABSTRAK: Campuran α dan zarah γ-Fe2O3 bersaiz nano disintesiskan dan kesan toksidnya terhadap sel HeLa dikaji dibawah aruhan medan magnet arus ulang-alik (alternating current (AC)) dan keadaan photoexcited (proses ransangan atom atau molekul suatu bahan dengan penyerapan tenaga sinaran) pada suhu bilik. Penemuan mendedahkan bahawa peratusan sel yang musnah bertambah dengan pertambahan dos untuk semua jenis rawatan. Akhirnya, 99% sel kanser dimusnahkan pada kadar dos 1.2mL setelah didedahkan terhadap kombinasi medan magnet AC dan keadaan photoexcited (T3) dimana 89% dan 83% sel HeLa dimusnahkan dengan hanya di bawah aruhan medan magnet AC (T1) atau hanya pada keadaan photoexcited (T2) pada kadar dos yang sama.KEY WORDS : Cancer, Hyperthermia, Iron oxide nanoparticles, Heat dissipation,    Cytotoxicity, HeLa cell.

scholarly journals Properties of assembly of superparamagnetic nanoparticles in viscous liquid

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
N. A. Usov ◽  
R. A. Rytov ◽  
V. A. Bautin
Keyword(s):  
Magnetic Field ◽  
Uniaxial Anisotropy ◽  
Particle Diameter ◽  
Magnetization Vector ◽  
Anisotropy Field ◽  
Linear Response Theory ◽  
Superparamagnetic Nanoparticles ◽  
Magnetic Field Direction ◽  
Ac Magnetic Field ◽  
Particle Anisotropy

AbstractDetailed calculations of the specific absorption rate (SAR) of a dilute assembly of iron oxide nanoparticles with effective uniaxial anisotropy dispersed in a liquid are performed depending on the particle diameters, the alternating (ac) magnetic field amplitude H0 and the liquid viscosity. For small and moderate H0 values with respect to particle anisotropy field Hk the SAR of the assembly as a function of the particle diameter passes through a characteristic maximum and then reaches a plateau, whereas for sufficiently large amplitudes, H0 ~ Hk, the SAR increases monotonically as a function of diameter. The realization of viscous and magnetic oscillation modes for particle unit magnetization vector and director for moderate and sufficiently large H0 values, respectively, explains this behavior. It is found that the SAR of the assembly changes inversely with the viscosity only in a viscous mode, for nanoparticles of sufficiently large diameters. In the magnetic mode the SAR of the assembly is practically independent of the viscosity, since in this case the nanoparticle director only weakly oscillates around the ac magnetic field direction. The conditions for the validity of the linear response theory have been clarified by comparison with the numerical simulation data.

scholarly journals Super-Antiferromagnetics Nanoparticles for Magnetic Hyperthermia Applications: Effect of the Dc and Ac Magnetic Field

2020 ◽  
pp. 1-5
Author(s):  
Bachir Ouari ◽  
◽  
Malika Madani ◽  
Keyword(s):  
Magnetic Field ◽  
Magnetic Fields ◽  
Diffusion Model ◽  
Magnetic Hysteresis ◽  
Hysteresis Loops ◽  
Magnetic Characteristic ◽  
Magnetic Hyperthermia ◽  
Cancer Treatments ◽  
Ac Magnetic Field

The importance of magnetic hyperthermia cancer treatments is based on the magnetic characteristic of the nanoparticles and their dependence on the DC and AC magnetic fields. In this paper we Study the dynamic magnetic hysteresis (DMH) of Super Antiferromagnetic nanoparticle, we use Brown’s continuous diffusion model to we evaluate the hysteresis loops, for extensive ranges of the anisotropy, the ac and dc magnetic fields.

Pseudo single domain NiZn-γFe2O3 colloidal superparamagnetic nanoparticles for MRI-guided hyperthermia application

2021 ◽  
Author(s):  
Ji-wook Kim ◽  
JIE WANG ◽  
Hyungsub Kim ◽  
Seongtae Bae
Keyword(s):  
Superparamagnetic Nanoparticles ◽  
Single Domain ◽  
Contrast Imaging ◽  
Physical Reason ◽  
Heat Induction ◽  
Highly Efficient ◽  
Magnetic Softness ◽  
Mri Guided

Abstract MRI (Magnetic Resonance Imaging)-guided magnetic nanofluid hyperthermia (MNFH) is highly desirable in cancer treatment because it can allow for diagnosis, therapeutics, and prognosis simultaneously. However, the application of currently developed iron-oxide based superparamagnetic nanoparticles (IOSPNPs) for a MRI-guided MNFH agent is technically limited by the low AC heat induction power at the physiologically tolerable range of AC magnetic field (HAC,safe), and the low transverse r2-relaxivity responsible for the insufficient heating of cancers, and the low resolution of contrast imaging, respectively. Here, pseudo single domain colloidal NixZn1-x-γFe2O3 (x = 0.6) superparamagnetic nanoparticle (NiZn-γFe2O3 PSD-SPNP) physically and theoretically designed at the HAC,safe, specifically by the applied frequency, is proposed for a highly enhanced MRI-guided MNFH agent application. The NiZn-γFe2O3 PSD-SPNP showed the superparamagnetic characteristics, significantly enhanced AC heat induction performance, and highly improved saturation magnetization that are desirable for highly efficient MRI-guided MNFH agent applications. According to the analyzed results, the remarkably enhanced effective relaxation time constant and its dependent out-of-phase magnetic susceptibility as well as the DC/AC magnetic softness optimized by the PSD-SPNP at the HAC,safe were revealed as the main physical reason for the significance. All the fundamental in-vitro and in-vivo experimental results demonstrated that the physically designed NiZn-γFe2O3 PSD-SPNP is bio-technically feasible for a highly efficient MRI-guided MNFH agent for future cancer nanomedicine.

scholarly journals Ultra-high rate of temperature increment from superparamagnetic nanoparticles for highly efficient hyperthermia

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jae-Hyeok Lee ◽  
Bosung Kim ◽  
Yongsub Kim ◽  
Sang-Koog Kim
Keyword(s):  
Heat Dissipation ◽  
Initial Temperature ◽  
Magnetic Hyperthermia ◽  
Superparamagnetic Nanoparticles ◽  
High Rate ◽  
Spin Excitation ◽  
Highly Efficient ◽  
Temperature Increment ◽  
Spin Resonance ◽  
Increment Rate

AbstractThe magneto-thermal effect, which represents the conversion of magnetostatic energy to heat from magnetic materials, has been spotlighted for potential therapeutic usage in hyperthermia treatments. However, the realization of its potential has been challenged owing to the limited heating from the magnetic nanoparticles. Here, we explored a new-concept of magneto-thermal modality marked by low-power-driven, fast resonant spin-excitation followed by consequent energy dissipation, which concept has yet to be realized for current hyperthermia applications. We investigated the effect of spin resonance-mediated heat dissipation using superparamagnetic Fe3O4 nanoparticles and achieved an extraordinary initial temperature increment rate of more than 150 K/s, which is a significant increase in comparison to that for the conventional magnetic heat induction of nanoparticles. This work would offer highly efficient heat generation and precision wireless controllability for realization of magnetic-hyperthermia-based medical treatment.

Sign in / Sign up

Export Citation Format

Share Document