Enhanced drug retention by anthracene crosslinked nanocomposites for bimodal imaging-guided phototherapy

Nanoscale ◽  
2021 ◽  
Author(s):  
Xiaoshan Fan ◽  
Lingjie Ke ◽  
Hongwei Cheng ◽  
Hu Chen ◽  
Zhiguo Li ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Drug Delivery ◽  
Magnetic Resonance ◽  
Real Time ◽  
Combined Therapy ◽  
Resonance Imaging ◽  
Mri Contrast ◽  
Bimodal Imaging ◽  
Magnetic Resonance Imaging Mri ◽  
Time Diagnosis

Efficient drug delivery, multifunctional combined therapy and real-time diagnosis are the main hallmarks in the exploitation of precision nanomedicine. Herein, an anthracene-functionalized micelle vesicle containing magnetic resonance imaging (MRI) contrast,...

scholarly journals Magnetism for Drug Delivery, MRI and Hyperthermia Applications: a Review

2020 ◽  
Vol 11 (2) ◽  
pp. 8654-8668
Keyword(s):  
Magnetic Resonance Imaging ◽  
Drug Delivery ◽  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Magnetic Resonance ◽  
Mri Contrast Agents ◽  
Oxide Nanoparticles ◽  
Resonance Imaging ◽  
Mri Contrast ◽  
Magnetic Resonance Imaging Mri

Superparamagnetic nanoparticles contain unique magnetic properties that differ from the bulk materials and are able to function at a cellular level due to their size, shape, and surface characteristics. These features make them attractive candidates for drug delivery systems, thermal mediators in hyperthermia, and magnetic resonance imaging (MRI) contrast agents. This review provides an up-to-date overview of the application of iron oxide nanoparticles in cancer diagnosis, drug delivery, treatment, and safety concerns related to these materials are considered, as well. Furthermore, the general principles and challenges of the magnetic behavior of nanoparticles in the field of oncology are also discussed. Firstly, the basic requirements for magnetic nanoparticles for biomedical applications are outlined. The close link between structure, shape, size, and magnetic characterization are described, which is considered essential for non-invasive imaging modality, innovative magnetic-driven nanocarriers, and treatment based on the overheating. In conclusion, investigation of the toxicity profile of novel nanoparticles is provided, as well. In the current review, the attention is focused on the role of magnetic nanoparticles, especially iron oxide nanoparticles in some bioapplications such as magnetic resonance imaging (MRI) contrast agents, targeted drug delivery, and magnetic hyperthermia systems.

Biocompatible dextran-coated gadolinium-doped cerium oxide nanoparticles as MRI contrast agents with high T1 relaxivity and selective cytotoxicity to cancer cells

2021 ◽  
Author(s):  
Anton Popov ◽  
Maxim Artemovich Abakumov ◽  
Irina Savintseva ◽  
Artem Ermakov ◽  
Nelly Popova ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Resonance Imaging ◽  
Mri Contrast ◽  
Selective Cytotoxicity ◽  
Magnetic Resonance Imaging Mri

Gd-based complexes are widely used as magnetic resonance imaging (MRI) contrast agents. The safety of previously approved contrast agents is questionable and is being re-assessed. The main causes of concern...

Switchable 19F MRI polymer theranostics: towards in situ quantifiable drug release

2017 ◽  
Vol 8 (34) ◽  
pp. 5157-5166 ◽  
Author(s):  
A. V. Fuchs ◽  
A. P. Bapat ◽  
G. J. Cowin ◽  
K. J. Thurecht
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Hyperbranched Polymer ◽  
Relaxation Times ◽  
Mri Contrast Agent ◽  
Resonance Imaging ◽  
Mri Contrast ◽  
19F Mri ◽  
Magnetic Resonance Imaging Mri

A switchable polymeric 19F magnetic resonance imaging (MRI) contrast agent was synthesised whereby the transverse (T2) relaxation times increased as a therapeutic was released from a hyperbranched polymer (HBP) scaffold.

scholarly journals Preparation and application of various nanoparticles in biology and medicine

2013 ◽  
Vol 3 (1) ◽  
pp. 2 ◽  
Author(s):  
Vardan Gasparyan
Keyword(s):  
Magnetic Resonance Imaging ◽  
Drug Delivery ◽  
Silver Nanoparticles ◽  
Optical Properties ◽  
Mri Contrast Agents ◽  
Resonance Imaging ◽  
Gold And Silver Nanoparticles ◽  
Mri Contrast ◽  
Cellular Processes ◽  
Magnetic Resonance Imaging Mri

The present paper considers prospects for application of various nanoparticles in biology and medicine. Here are presented data on preparation of gold and silver nanoparticles, and effects of shape of these nanoparticles on their optical properties. Application of these nanoparticles in diagnostics, for drug delivery and therapy, and preparation of magnetic nanoparticles from iron and cobalt salts are also discussed. Application of these nanoparticles as magnetic resonance imaging (MRI) contrast agents and as vehicles for drug delivery, and preparation of quantum dots and their application as prospective nanoparticles for multiplex analysis and for visualization of cellular processes will be tackled. Finally, prospects for new types of nanocomposites (metallic nano-shells) will be not overlooked.

scholarly journals Effect of Gd and Dy Concentrations in Layered Double Hydroxides on Contrast in Magnetic Resonance Imaging

Processes ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 462 ◽  
Author(s):  
Karina Nava Andrade ◽  
Gregorio Guadalupe Carbajal Arízaga ◽  
José Antonio Rivera Mayorga
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Resonance Imaging ◽  
Mri Contrast ◽  
Molar Ratios ◽  
Magnetic Resonance Imaging Mri ◽  
Double Hydroxide ◽  
Double Hydroxides

In this work, we explore the synthesis of layered double hydroxide (LDH) particles containing different molar ratios of Gd3+ and Dy3+ cations. A single crystalline phase was obtained for Zn2.0Al0.75Gd0.125Dy0.125-LDH and Zn2.0Al0.5Gd0.25Dy0.25-LDH, and their efficiency as contrast agents was evaluated by T1- and T2-weighted magnetic resonance imaging (MRI). Both GdDy-LDHs exhibited longitudinal relaxivity (r1) higher than a commercial reference. The highest contrast in the T1 mode was achieved with the Zn2.0Al0.75Gd0.125Dy0.125-LDH, which contained the lowest concentration of lanthanides; this efficiency is related to the lowest amount of carbonate anions complexing the lanthanide sites. On the contrary, the best contrast in the T2 mode was achieved with Zn2.0Al0.5Gd0.25Dy0.25-LDH. Zn2.0Al0.75Gd0.125Dy0.125-LDH and Zn2.0Al0.5Gd0.25Dy0.25-LDH presented r2/r1 ratios of 7.9 and 22.5, respectively, indicating that the inclusion of gadolinium and dysprosium into layered structures is a promising approach to the development of efficient bimodal (T1/T2) MRI contrast agents.

scholarly journals Ferritin: A Platform for MRI Contrast Agents Delivery

Inorganics ◽  
2019 ◽  
Vol 7 (3) ◽  
pp. 33 ◽  
Author(s):  
Maria Ruggiero ◽  
Diego Alberti ◽  
Valeria Bitonto ◽  
Simonetta Geninatti Crich
Keyword(s):  
Magnetic Resonance Imaging ◽  
Targeted Therapy ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Resonance Imaging ◽  
Mri Contrast ◽  
Magnetic Resonance Imaging Mri ◽  
Accurate Imaging ◽  
Unique Surface

The search for high relaxivities and increased specificity continues to be central to the development of paramagnetic contrast agents for magnetic resonance imaging (MRI). Ferritin, due to its unique surface properties, architecture, and biocompatibility, has emerged as a natural nanocage that can potentially help to reach both these goals. This review aims to highlight recent advances in the use of ferritin as a nanoplatform for the delivery of metal-based MRI contrast agents (containing Gd3+, Mn2+, or Fe2O3) alone or in combination with active molecules used for therapeutic purposes. The collected results unequivocally show that the use of ferritin for contrast agent delivery leads to more accurate imaging of cancer cells and a significantly improved targeted therapy.

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