Neutrophil mediated postoperative photoimmunotherapy against melanoma skin cancer

Nanoscale ◽  
2021 ◽  
Author(s):  
Yunyun Wu ◽  
Xiaoqing Han ◽  
Runxiao Zheng ◽  
Hongda Chen ◽  
Jiao Yan ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Cancer Patients ◽  
Recurrence Rate ◽  
Surgical Resection ◽  
Cause Of Death ◽  
Treatment Option ◽  
Tumor Recurrence ◽  
Primary Treatment ◽  
Tumor Recurrence Rate ◽  
Melanoma Skin

Surgery is the primary treatment option for most melanoma, however, high tumor recurrence rate after surgical resection becomes the main cause of death in cancer patients. Development of efficient drug...

scholarly journals Management of Acute Radiodermatitis in Non-Melanoma Skin Cancer Patients Using Electrospun Nanofibrous Patches Loaded with Pinus halepensis Bark Extract

Cancers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 2596
Author(s):  
Aikaterini Kyritsi ◽  
Stefanos Kikionis ◽  
Anna Tagka ◽  
Nikolaos Koliarakis ◽  
Antonia Evangelatou ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Skin Cancer ◽  
Cancer Patients ◽  
Pinus Halepensis ◽  
Radiation Therapy Oncology Group ◽  
Bark Extract ◽  
Skin Reactions ◽  
Non Melanoma Skin Cancer ◽  
Patient Reported ◽  
Melanoma Skin

Acute radiodermatitis is the most common side effect in non-melanoma skin cancer patients undergoing radiotherapy. Nonetheless, despite the ongoing progress of clinical trials, no effective regimen has been found yet. In this study, a non-woven patch, comprised of electrospun polymeric micro/nanofibers loaded with an aqueous extract of Pinus halepensis bark (PHBE), was fabricated and clinically tested for its efficacy to prevent radiodermatitis. The bioactivity of the PHBE patch was evaluated in comparison with a medical cream indicated for acute radiodermatitis. Twelve volunteer patients were selected and randomly assigned to two groups, applying either the PHBE patch or the reference cream daily. Evaluation of radiation-induced skin reactions was performed during the radiotherapy period and 1 month afterwards according to the Radiation Therapy Oncology Group (RTOG) grading scale, photo-documentation, patient-reported outcomes (Visual Analog Scale, questionnaire), biophysical measurements (hydration, transepidermal water loss, erythema, melanin), and image analysis. In contrast with the reference product, the PHBE patch showed significant anti-inflammatory activity and restored most skin parameters to normal levels 1 month after completion of radiation therapy. No adverse event was reported, indicating that the application of the PHBE patch can be considered as a safe medical device for prophylactic radiodermatitis treatment.

Practical indications for the management of non-melanoma skin cancer patients

2017 ◽  
Vol 152 (3) ◽  
Author(s):  
Alessandro Di Stefani ◽  
Laura Del Regno ◽  
Alfredo Piccerillo ◽  
Ketty Peris
Keyword(s):  
Skin Cancer ◽  
Cancer Patients ◽  
Non Melanoma Skin Cancer ◽  
Melanoma Skin

Investigating the potential for protective effect against non-melanoma skin cancer in cancer patients receiving oral niacin

2017 ◽  
Vol 152 (4) ◽  
Author(s):  
Chantelle Carneiro ◽  
Beatrice Nardone ◽  
Tina Kiguradze ◽  
Alba Posligua ◽  
Dennis P. West ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Protective Effect ◽  
Cancer Patients ◽  
Non Melanoma Skin Cancer ◽  
Melanoma Skin

scholarly journals Clinical efficacy and safety of bone cement combined with radiofrequency ablation in the treatment of spinal metastases

BMC Neurology ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Nanning Lv ◽  
Rui Geng ◽  
Feng Ling ◽  
Zhangzhe Zhou ◽  
Mingming Liu
Keyword(s):  
Radiofrequency Ablation ◽  
Bone Cement ◽  
Recurrence Rate ◽  
Tumor Recurrence ◽  
Spinal Metastases ◽  
Efficacy And Safety ◽  
Significant Difference ◽  
Group A ◽  
Group B ◽  
Tumor Recurrence Rate

Abstract Background To investigate the clinical efficacy and safety of bone cement combined with radiofrequency ablation (RFA) in the treatment of spinal metastases. Methods The medical records of patients with spinal metastatic tumor admitted to our hospital from January 2016 to December 2018 were retrospectively analyzed. Based on different surgical methods, the patients were divided into groups A (treated with RFA combined with bone cement) and B (treated with bone cement only). Group A included 35 patients with 47 segments of diseased vertebral bodies. Group B consisted of 52 patients with 78 vertebral segments. Pain, quality of life score, vertebra height, bone cement leakage, postoperative tumor recurrence, and complications were assessed 3 days and 1 and 6 months after surgery. Results All the patients had smooth operation without paraplegia, spinal cord injury, and perioperative death. Visual analogue scales (VAS) and Oswestry Disability Index (ODI) scores of the two groups significantly improved 3 days and 1 month after surgery compared with those before surgery (P < 0.05), but no significant difference was observed between the two groups (P > 0.05). Six months after surgery, the VAS and ODI scores of patients in group A were lower than those in group B, with statistically significant differences (P < 0.05). The postoperative vertebral body height of the two groups significantly increased compared with that before surgery, and the difference was statistically significant (P < 0.05). Meanwhile, no significant difference was observed between the two groups (P > 0.05). Postoperative bone cement permeability in group A was 6.4%, and postoperative tumor recurrence rate was 11.4%. The permeability of bone cement in group B was 20.5%, and the tumor recurrence rate was 30.8%. The bone cement permeability and tumor recurrence rate in group A were lower than those in group B, with statistically significant differences (P < 0.05). Conclusions Bone cement combined with RFA for the treatment of spinal metastases can achieve good efficacy, desirable analgesic effect, low incidence of complications, small surgical trauma, and high safety. The proposed method has the value of clinical popularization and application.

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