A co-delivery nanoplatform for Lignan-derived compound and perfluorocarbon tuning IL-25 secretion and oxygen level in tumor microenvironments for meliorative tumor radiotherapy

Nanoscale ◽  
2021 ◽  
Author(s):  
Zhenyu Duan ◽  
Qiang Luo ◽  
Lei Gu ◽  
Xiaoling Li ◽  
Hongyan Zhu ◽  
...  
Keyword(s):  
Therapeutic Efficacy ◽  
Glycolic Acid ◽  
Treatment Technique ◽  
Oxygen Level ◽  
Tumor Microenvironments ◽  
Hypoxic Environment ◽  
Control Tumor ◽  
Tumor Metastases ◽  
Localized Treatment

A hypoxic environment in tumors hampers the therapeutic efficacy of radiotherapy. Moreover, radiotherapy, a localized treatment technique, can barely control tumor metastases. Herein, poly(lactic co-glycolic acid) was used to encapsulate...

scholarly journals Controlled Release of Strontium through Neutralization Reaction within a Methoxy(Polyethylene Glycol)-Polyesterc hydrogel

2017 ◽  
Vol 15 (2) ◽  
pp. 162-169 ◽  
Author(s):  
Sydney Peng ◽  
Zhi-Teng Lai ◽  
Ding-Wei Hong ◽  
I-Ming Chu ◽  
Po-Liang Lai
Keyword(s):  
Polyethylene Glycol ◽  
Glycolic Acid ◽  
Time Frame ◽  
Neutralization Reaction ◽  
Bone Void Filler ◽  
Potential Acid ◽  
Methoxy Polyethylene Glycol ◽  
Localized Treatment

Background The aim of this study was to develop a minimally invasive hydrogel system that can release strontium ions, an element that has been shown to increase osteoblast proliferation and prohibit bone resorption, in a controlled manner. Methods SrCO3 was selected as the salt of choice due to potential acid neutralization reaction between SrCO3 and degradation by-products of methoxy(polyethylene glycol)- co-poly(lactic- co-glycolic acid) (mPEG-PLGA): namely, lactic acid and glycolic acid. SrCO3 was incorporated into mPEG-PLGA hydrogel, and the system was assessed for gelation properties, drug release and biocompatibility. Results SrCO3 incorporation at hydrogel to SrCO3 ratios of 5:1, 3:1 and 1:1 (wt%) did not compromise the thermosensitivity of mPEG-PLGA hydrogels. Furthermore, incorporation of SrCO3 at 1:1 ratio prevented copolymer self-catalysis and decreased hydrogel weight loss from 85% to 61% in vitro after 30 days. During the 30-day time frame, zero-order strontium release was observed and was correlated to hydrogel degradation and acidity. The addition of SrCO3 also improved in vivo hydrogel biocompatibility, due to moderation of acidic microenvironment and amelioration of inflammatory response. Conclusions These results showed that the described system is suitable for the extended release of strontium and exhibits potential for localized treatment for osteoporosis or as a bone void filler.

scholarly journals Polymer-loaded hydrogels serve as depots for lactate and mimic “cold” tumor microenvironments

2020 ◽  
Vol 8 (21) ◽  
pp. 6056-6068
Author(s):  
Riley Allen ◽  
Emilie Ivtchenko ◽  
Bhasirie Thuamsang ◽  
Rapeepat Sangsuwan ◽  
Jamal S. Lewis
Keyword(s):  
Tumor Microenvironment ◽  
Glycolic Acid ◽  
Colony Stimulating Factor ◽  
Tumor Microenvironments ◽  
Macrophage Colony Stimulating Factor ◽  
Macrophage Colony ◽  
Peptide Hydrogels ◽  
Stimulating Factor

Peptide hydrogels loaded with granulocyte-macrophage colony stimulating factor and poly-(lactic-co-glycolic acid) microparticles can recapitulate lactate concentrations and the immunosuppressive nature of the tumor microenvironment.

scholarly journals Vascular Disrupting Agent Arsenic Trioxide Enhances Thermoradiotherapy of Solid Tumors

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Robert J. Griffin ◽  
Brent W. Williams ◽  
Nathan A. Koonce ◽  
John C. Bischof ◽  
Chang W. Song ◽  
...  
Keyword(s):  
Arsenic Trioxide ◽  
Solid Tumors ◽  
Therapeutic Efficacy ◽  
Vascular Disrupting Agent ◽  
Vascular Disruption ◽  
Control Tumor Growth ◽  
Powerful Means ◽  
Control Tumor ◽  
Hypofractionated Radiation

Our previous studies demonstrated arsenic trioxide- (ATO-) induced selective tumor vascular disruption and augmentation of thermal or radiotherapy effect against solid tumors. These results suggested that a trimodality approach of radiation, ATO, and local hyperthermia may have potent therapeutic efficacy against solid tumors. Here, we report the antitumor effect of hypofractionated radiation followed by ATO administration and local 42.5 °C hyperthermia and the effects of cisplatin and thermoradiotherapy. We found that the therapeutic efficacy of ATO-based thermoradiotherapy was equal or greater than that of cisplatin-based thermoradiotherapy, and marked evidence ofin vivoapoptosis and tumor necrosis were observed in ATO-treated tumors. We conclude that ATO-based thermoradiotherapy is a powerful means to control tumor growth by using vascular disruption to augment the effects of thermal and radiation therapy.

scholarly journals Hypoxic Physiological Environments in a Gas-Regulated Microfluidic Device

Micromachines ◽  
2018 ◽  
Vol 10 (1) ◽  
pp. 16
Author(s):  
Insu Lee ◽  
Jin Woo ◽  
Min Lee ◽  
Tae-Joon Jeon ◽  
Sun Kim
Keyword(s):  
Human Physiology ◽  
Computational Simulation ◽  
Hypoxic Condition ◽  
Oxygen Level ◽  
Critical Factors ◽  
Permeable Membrane ◽  
Hypoxic Environment ◽  
O2 Concentration ◽  
Tissue Models

Hypoxic environment is known as one of the critical factors in various physiological/pathological processes. It is imperative to recapitulate oxygen level in microscale for human physiology/pathology induced by hypoxia. Herein, we propose an oxygen-regulating system that can be applied to in vitro tissue models. We fabricated a microdevice with a gas-permeable membrane, allowing oxygen diffusion without direct contact to cells. We verified the formation of oxygen level less than 2% O2 concentration inside the device through computational simulation and experiments. H9c2 heart myoblasts were exposed to hypoxic condition in the device, and their cell viability were investigated. We anticipate that our system will be integrated with a platform to study hypoxia-induced human physiology and pathology as an efficient oxygen-regulating system.

scholarly journals Seed- and Soil-Dependent Differences in Murine Breast Tumor Microenvironments Dictate Anti-PD-L1 IgG Delivery and Therapeutic Efficacy

Pharmaceutics ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 530
Author(s):  
Yan Ting Liu ◽  
Shreya Goel ◽  
Megumi Kai ◽  
Jose Alberto Moran Guerrero ◽  
Thao Nguyen ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Blood Vessels ◽  
Therapeutic Efficacy ◽  
Cancer Metastasis ◽  
Immune Cell ◽  
Inverse Correlation ◽  
Parental Cell ◽  
Tumor Microenvironments ◽  
Cell Accumulation ◽  
The Difference

We sought to determine if Stephen Paget’s “seed and soil” hypothesis of organ-preference patterns of cancer metastasis can explain the development of heterogeneity in a tumor microenvironment (TME) as well as immunotherapeutic delivery and efficacy. We established single-cell-derived clones (clones 1 and 16) from parental 4T1 murine breast cancer cells to create orthotopic primary and liver metastasis models to deconvolute polyclonal complexity cancer cells and the difference in TME-derived heterogeneities. Tumor-bearing mice were treated with anti-PD-L1 IgG or a control antibody, and immunofluorescent imaging and quantification were then performed to evaluate the therapeutic efficacy on tumor growth, the delivery of therapy to tumors, the development of blood vessels, the expression of PD-L1, the accumulation of immune cells, and the amount of coagulation inside tumors. The quantification showed an inverse correlation between the amount of delivered therapy and therapeutic efficacy in parental-cell-derived tumors. In contrast, tumors originating from clone 16 cells accumulated a significantly greater amount of therapy and responded better than clone-1-derived tumors. This difference was greater when tumors grew in the liver than the primary site. A similar trend was found in PD-L1 expression and immune cell accumulation. However, the change in the number of blood vessels was not significant. In addition, the amount of coagulation was more abundant in clone-1-derived tumors when compared to others. Thus, our findings reconfirmed the seed- and soil-dependent differences in PD-L1 expression, therapeutic delivery, immune cell accumulation, and tumor coagulation, which can constitute a heterogeneous delivery and response of immunotherapy in polyclonal tumors growing in different organs.

scholarly journals Mechanisms of vasculogenic mimicry in hypoxic tumor microenvironments

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Xiaoxu Wei ◽  
Yunhua Chen ◽  
Xianjie Jiang ◽  
Miao Peng ◽  
Yiduo Liu ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Malignant Tumors ◽  
Vasculogenic Mimicry ◽  
Main Body ◽  
Differentiation Potential ◽  
Ecm Remodeling ◽  
Tumor Microenvironments ◽  
Hypoxic Environment ◽  
Hypoxic Tumor ◽  
Aggressive Tumors

Abstract Background Vasculogenic mimicry (VM) is a recently discovered angiogenetic process found in many malignant tumors, and is different from the traditional angiogenetic process involving vascular endothelium. It involves the formation of microvascular channels composed of tumor cells; therefore, VM is considered a new model for the formation of new blood vessels in aggressive tumors, and can provide blood supply for tumor growth. Many studies have pointed out that in recent years, some clinical treatments against angiogenesis have not been satisfactory possibly due to the activation of VM. Although the mechanisms underlying VM have not been fully elucidated, increasing research on the soil “microenvironment” for tumor growth suggests that the initial hypoxic environment in solid tumors is inseparable from VM. Main body In this review, we describe that the stemness and differentiation potential of cancer stem cells are enhanced under hypoxic microenvironments, through hypoxia-induced epithelial-endothelial transition (EET) and extracellular matrix (ECM) remodeling to form the specific mechanism of vasculogenic mimicry; we also summarized some of the current drugs targeting VM through these processes, suggesting a new reference for the clinical treatment of tumor angiogenesis. Conclusion Overall, the use of VM inhibitors in combination with conventional anti-angiogenesis treatments is a promising strategy for improving the effectiveness of targeted angiogenesis treatments; further, considering the importance of hypoxia in tumor invasion and metastasis, drugs targeting the hypoxia signaling pathway seem to achieve good results.

scholarly journals TO STUDY THE THERAPEUTIC EFFICACY OF THE GLYCOLIC ACID PEELING, SALICYLIC ACID PEELING AND MICRO-DERMABRASION IN THE TREATMENT OF MELASMA

2020 ◽  
Vol 4 (6) ◽  
Author(s):  
Manish Kumar Meena ◽  
Deepika Meena
Keyword(s):  
Salicylic Acid ◽  
Therapeutic Efficacy ◽  
Glycolic Acid ◽  
Poor Response ◽  
Excellent Response ◽  
Indian Patients ◽  
One Year

Background: This study is aimed the therapeutic efficacy of the glycolic acid peeling, salicylic acid peeling and micro-dermabrasion in the treatment of melasma. Methods: The present study was carried out in the department of dermatology in a teaching institute. A total of 90 patients were enrolled for the study over a period of one year. Results: In those who were treated with GA peeling; 20.00 % had excellent response, 30.00 % had good response, 36.67% had fair response and only 13.33%  had poor response. Out of total 30 patients treated with SA peeling 16.67% had excellent response, 20.00% had good response, 40.00% had fair response and 23.33% had poor response. In this group no patient had excellent response while good response was seen in 26.67%, fair   response in 36.67% and poor  response in another 36.67% patients. Conclusion: all three agents were effective and safe in Indian patients, with Glycolic Acid Peel being better effect on melasma patients.  Keywords: Therapeutic , Melasma,Pregnancy.

Sign in / Sign up

Export Citation Format

Share Document