Thermally induced silane dehydrocoupling on porous silicon nanoparticles for ultra-long-acting drug release

Nanoscale ◽  
2021 ◽  
Vol 13 (37) ◽  
pp. 15560-15568
Author(s):  
Ji Hyeon Oh ◽  
Rae Hyung Kang ◽  
Jaehoon Kim ◽  
Eun-Kyoung Bang ◽  
Dokyoung Kim
Keyword(s):  
Porous Silicon ◽  
Drug Release ◽  
Silicon Nanoparticles ◽  
Thermally Induced ◽  
Porous Silicon Nanoparticles ◽  
Long Acting ◽  
Nano Formulation ◽  
First Time

An ultra-long-acting drug-releasable (>2 weeks) nano-formulation based on porous silicon nanoparticles (pSiNPs) that are prepared using the thermally induced silane dehydrocoupling, an amphiphilic lipid-coating, and is disclosed for the first time.

Fusogenic porous silicon nanoparticles as a broad-spectrum immunotherapy against bacterial infections

2021 ◽  
Author(s):  
Byungji Kim ◽  
Qinglin Yang ◽  
Leslie W. Chan ◽  
Sangeeta N. Bhatia ◽  
Erkki Ruoslahti ◽  
...  
Keyword(s):  
Porous Silicon ◽  
Broad Spectrum ◽  
Therapeutic Efficacy ◽  
Bacterial Infections ◽  
Silicon Nanoparticles ◽  
First Line ◽  
Gram Positive ◽  
Gram Negative ◽  
Porous Silicon Nanoparticles

RNAi-mediated immunotherapy provided by fusogenic porous silicon nanoparticles demonstrates superior therapeutic efficacy against both Gram-positive and Gram-negative bacterial infections compared with first-line antibiotics.

scholarly journals Tracking the Fate of Porous Silicon Nanoparticles Delivering a Peptide Payload by Intrinsic Photoluminescence Lifetime

2018 ◽  
Vol 30 (35) ◽  
pp. 1802878 ◽  
Author(s):  
Yusung Jin ◽  
Dokyoung Kim ◽  
Hajung Roh ◽  
Sojeong Kim ◽  
Sazid Hussain ◽  
...  
Keyword(s):  
Porous Silicon ◽  
Silicon Nanoparticles ◽  
Porous Silicon Nanoparticles ◽  
Photoluminescence Lifetime

scholarly journals Ex vivo biodistribution of gallium-68-labeled porous silicon nanoparticles

2020 ◽  
Vol 1439 ◽  
pp. 012035
Author(s):  
V K Tishchenko ◽  
V. M. Petriev ◽  
A A Mikhailovskaya ◽  
O A Smoryzanova ◽  
A V Kabashin ◽  
...  
Keyword(s):  
Porous Silicon ◽  
Silicon Nanoparticles ◽  
Ex Vivo ◽  
Porous Silicon Nanoparticles ◽  
Gallium 68 ◽  
Ex Vivo Biodistribution

Direct visualization of drug release in injectable implant by laser induced breakdown spectroscopy (LIBS)

2019 ◽  
Vol 34 (7) ◽  
pp. 1351-1354 ◽  
Author(s):  
Lanfang Zou ◽  
Mallory J. Stenslik ◽  
Morgan B. Giles ◽  
James D. Ormes ◽  
Maureen Marsales ◽  
...  
Keyword(s):  
Drug Release ◽  
Laser Induced Breakdown Spectroscopy ◽  
Imaging Method ◽  
Direct Visualization ◽  
Release Process ◽  
Breakdown Spectroscopy ◽  
Laser Induced Breakdown ◽  
2D Imaging ◽  
Long Acting ◽  
First Time

A novel laser induced breakdown spectroscopy (LIBS) 2D imaging method is used to directly visualize the drug release process of long-acting injectable (LAI) implants for the first time.

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