Self-Assembly of Virulent Amyloid-Derived Peptides into Nanoantibacterials

Nanoscale ◽  
2021 ◽  
Author(s):  
Wenlu Tu ◽  
Ke Xue ◽  
Shaofeng Lou ◽  
Chunlei Zhu ◽  
Zhilin Yu
Keyword(s):  
Antibacterial Activity ◽  
Self Assembly ◽  
Antibacterial Peptides

Current strategies for design of antibacterial peptides show limitation in development of assembled antibacterial peptides due to the challenges in simultaneously balancing the antibacterial activity and assembling behavior. Herein, we...

scholarly journals Synthesis and self-assembly of curcumin-modified amphiphilic polymeric micelles with antibacterial activity

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Caio H. N. Barros ◽  
Dishon W. Hiebner ◽  
Stephanie Fulaz ◽  
Stefania Vitale ◽  
Laura Quinn ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Self Assembly ◽  
Glycolic Acid ◽  
Extracellular Polymeric Substances ◽  
Polymeric Micelles ◽  
Polymeric Nanoparticles ◽  
Enhanced Resistance ◽  
Antimicrobial Nanoparticles ◽  
Good Penetration ◽  
Antibiofilm Agents

Abstract Background The ubiquitous nature of bacterial biofilms combined with the enhanced resistance towards antimicrobials has led to the development of an increasing number of strategies for biofilm eradication. Such strategies must take into account the existence of extracellular polymeric substances, which obstruct the diffusion of antibiofilm agents and assists in the maintenance of a well-defended microbial community. Within this context, nanoparticles have been studied for their drug delivery efficacy and easily customised surface. Nevertheless, there usually is a requirement for nanocarriers to be used in association with an antimicrobial agent; the intrinsically antimicrobial nanoparticles are most often made of metals or metal oxides, which is not ideal from ecological and biomedical perspectives. Based on this, the use of polymeric micelles as nanocarriers is appealing as they can be easily prepared using biodegradable organic materials. Results In the present work, micelles comprised of poly(lactic-co-glycolic acid) and dextran are prepared and then functionalised with curcumin. The effect of the functionalisation in the micelle’s physical properties was elucidated, and the antibacterial and antibiofilm activities were assessed for the prepared polymeric nanoparticles against Pseudomonas spp. cells and biofilms. It was found that the nanoparticles have good penetration into the biofilms, which resulted in enhanced antibacterial activity of the conjugated micelles when compared to free curcumin. Furthermore, the curcumin-functionalised micelles were efficient at disrupting mature biofilms and demonstrated antibacterial activity towards biofilm-embedded cells. Conclusion Curcumin-functionalised poly(lactic-co-glycolic acid)-dextran micelles are novel nanostructures with an intrinsic antibacterial activity tested against two Pseudomonas spp. strains that have the potential to be further exploited to deliver a secondary bioactive molecule within its core. Graphic Abstract

scholarly journals Efficient self-assembly of heterometallic triangular necklace with strong antibacterial activity

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Gui-Yuan Wu ◽  
Xueliang Shi ◽  
Hoa Phan ◽  
Hang Qu ◽  
Yi-Xiong Hu ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Self Assembly

Induction, selection and antibacterial activity of the antibacterial peptides from lepidopteran insect cultured cell lines

2008 ◽  
Vol 3 (2) ◽  
pp. 203-206
Author(s):  
Rong Peng ◽  
Zhong Yang ◽  
Kaiyu Liu ◽  
Hanchao Yao ◽  
Hong Yang ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Cell Lines ◽  
Antibacterial Peptides ◽  
Cultured Cell ◽  
Lepidopteran Insect

Controllable assembly of well-defined monodisperse Au nanoparticles on hierarchical ZnO microspheres for enhanced visible-light-driven photocatalytic and antibacterial activity

Nanoscale ◽  
2015 ◽  
Vol 7 (45) ◽  
pp. 19118-19128 ◽  
Author(s):  
Yuan Wang ◽  
Hua-Bin Fang ◽  
Yan-Zhen Zheng ◽  
Rongqin Ye ◽  
Xia Tao ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Visible Light ◽  
Self Assembly ◽  
Au Nanoparticles ◽  
Layer By Layer ◽  
Visible Light Driven ◽  
Assembly Technique

An excellent visible-light-driven photocatalyst composed of well-defined monodisperse Au nanoparticles on ZnO microspheres via a layer-by-layer self-assembly technique is demonstrated.

N-Reacetylated Oligochitosan: pH Dependence of Self-Assembly Properties and Antibacterial Activity

2017 ◽  
Vol 18 (5) ◽  
pp. 1491-1498 ◽  
Author(s):  
Inesa V. Blagodatskikh ◽  
Sergey N. Kulikov ◽  
Oxana V. Vyshivannaya ◽  
Evgeniya A. Bezrodnykh ◽  
Vladimir E. Tikhonov
Keyword(s):  
Antibacterial Activity ◽  
Self Assembly ◽  
Ph Dependence

Polyoxometalate-Driven Self-Assembly of Short Peptides into Multivalent Nanofibers with Enhanced Antibacterial Activity

2016 ◽  
Vol 128 (7) ◽  
pp. 2638-2641 ◽  
Author(s):  
Jingfang Li ◽  
Zhijun Chen ◽  
Mengcheng Zhou ◽  
Jiangbo Jing ◽  
Wen Li ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Self Assembly ◽  
Short Peptides
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