scholarly journals Extracellular vesicles from adipose stromal cells combined with a thermoresponsive hydrogel prevent esophageal stricture after extensive endoscopic submucosal dissection in a porcine model

Nanoscale ◽  
2021 ◽  
Author(s):  
Elise Coffin ◽  
Alice Grangier ◽  
Guillaume Perrod ◽  
Max Piffoux ◽  
Iris Marangon ◽  
...  
Keyword(s):  
Endoscopic Submucosal Dissection ◽  
Extracellular Vesicles ◽  
Stromal Cells ◽  
Esophageal Stricture ◽  
Porcine Model ◽  
High Yield ◽  
Adipose Stromal Cells ◽  
Thermoresponsive Hydrogel ◽  
Submucosal Dissection

We show herein that a combination of a biomaterial and extracellular vesicles (produced at a high yield by a turbulence stimulation from stromal cells) was effective in the prevention of esophageal stricture in a clinically relevant porcine model.

Prevention of esophageal stricture after endoscopic submucosal dissection using RNA-based silencing of carbohydrate sulfotransferase 15 in a porcine model

Endoscopy ◽  
2017 ◽  
Vol 49 (05) ◽  
pp. 491-497 ◽  
Author(s):  
Hiroki Sato ◽  
Seiji Sagara ◽  
Nao Nakajima ◽  
Teppei Akimoto ◽  
Kenji Suzuki ◽  
...  
Keyword(s):  
Endoscopic Submucosal Dissection ◽  
Esophageal Stricture ◽  
Porcine Model ◽  
Submucosal Dissection

scholarly journals Cell Sheet Transplantation for Esophageal Stricture Prevention after Endoscopic Submucosal Dissection in a Porcine Model

PLoS ONE ◽  
2016 ◽  
Vol 11 (3) ◽  
pp. e0148249 ◽  
Author(s):  
Guillaume Perrod ◽  
Gabriel Rahmi ◽  
Laetitia Pidial ◽  
Sophie Camilleri ◽  
Alexandre Bellucci ◽  
...  
Keyword(s):  
Endoscopic Submucosal Dissection ◽  
Esophageal Stricture ◽  
Porcine Model ◽  
Cell Sheet ◽  
Submucosal Dissection

Local Thymosin β4 Gel Injection Prevents Esophageal Stricture after Circumferential Endoscopic Submucosal Dissection in a Porcine Model

2018 ◽  
Vol 37 (2) ◽  
pp. 87-92 ◽  
Author(s):  
Hua Wang ◽  
Qun Shuai ◽  
Jian Tang ◽  
Dan Long ◽  
Chen Xu ◽  
...  
Keyword(s):  
Endoscopic Submucosal Dissection ◽  
Esophageal Stricture ◽  
Porcine Model ◽  
Balloon Dilation ◽  
Control Group ◽  
Thymosin Β4 ◽  
Early Esophageal Cancer ◽  
Submucosal Dissection ◽  
Gel Injection ◽  
Experimental Group

Background: Endoscopic submucosal dissection (ESD) is widely used in the treatment of early esophageal cancer. However, the incidence of postoperative esophageal stricture is relatively high, especially after full circumferential ESD. Previous studies have shown that thymosin β4 (Tβ4) has anti-fibrotic activity and prevents scar formation. In this study, we investigated the safety and therapeutic effect of Tβ4 injection in preventing esophageal stricture after circumferential ESD in a porcine model. Methods: A total of 8 Bama pigs underwent esophageal circumferential ESD under anesthesia (n = 4 for experimental and control group). Local injection of Tβ4 gel was administered in the experimental group. Follow-up endoscopy was conducted, and balloon dilation (EBD) was performed to prevent the occurrence of esophageal stricture. Results: Esophageal stricture developed after circumferential ESD in all pigs. Local Tβ4 gel injection has shortened resolution of the stricture (p = 0.012) and was associated with a lesser number of EBD sessions (p = 0.002). The severity of esophageal stricture was milder in the experimental group (p = 0.046 vs. control group). No adverse events occurred in the study. Conclusions: Local Tβ4 gel injection appeared to be safe and effective for the prevention of esophageal stricture after circumferential ESD in a porcine model.

scholarly journals Mo1290 THE EFFECT OF PIRFENIDONE FOR ESOPHAGEAL STRICTURE AFTER CIRCUMFEREENTIAL ESOPHAGEAL ENDOSCOPIC SUBMUCOSAL DISSECTION IN A PORCINE MODEL

2020 ◽  
Vol 91 (6) ◽  
pp. AB420
Author(s):  
Shinji Hirano ◽  
Yasuaki Nagami ◽  
Taishi Sakai ◽  
Yuki Kakiya ◽  
Kojiro Tanoue ◽  
...  
Keyword(s):  
Endoscopic Submucosal Dissection ◽  
Esophageal Stricture ◽  
Porcine Model ◽  
Submucosal Dissection
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